CONTENTS ABSTRACT INTRODUCTION ALZHEIMER’S DISEASE PATHOGENESIS AND POTENTIAL PHARMACOLOGICAL TREATMENTS THE CHOLINERGIC HYPOTHESIS AND DONEPEZIL PHARMACOLOGICAL PROPERTIES DONEPEZIL IN ALZHEIMER’S DISEASE DONEPEZIL IN CEREBROVASCULAR DISORDERS DONEPEZIL IN OTHER CNS DISORDERS SIDE-EFFECTS AND MAJOR ADVERSE DRUG REACTIONS (ADRs) DISCONTINUATION AND SWITCHING POLICIES PHARMACOGENETICS AND PHARMACOGENOMICS OPTIMIZATION OF ALZHEIMER’S DISEASE THERAPEUTICS CONCLUSIONS REFERENCES