Congresos y Cursos

Regalando conocimiento habilitamos a los individuos

Congresos

2016

Cacabelos R. E-PodoFavalin-15999: Biological Properties and Pharmacogenetics in Parkinson’s Disease. DDTWC, Boston, 2016.
Carrera I, Fernandez-Novoa L, Vigo C, Cacabelos R. (2016) The dual effect of EB101 vaccine: A promising strategy for preventing and treating Alzheimer´s disease. DDTWC – P 9; Boston, USA.
Carrera I, Fernandez-Novoa L, Sampedro C, Cacabelos R. (2016) Neuroprotective Effects of Atremorine in MPTP Mouse Model of Parkinson´s Disease. DDTWC – P 37; Boston, USA.
Carrera I, Cacabelos R. (2016) In vitro and in vivo anti-tumor effects of E-Congerine-10423®. DDTWC – P 38; Boston, USA.
Teijido O, Carril JC, Cacabelos R. Risk polymorphisms associated with Dementia in the Spanish population. 4th International Conference on Predictive, Preventive, and Personalized Medicine and Molecular Diagnosis, Phoenix, Arizona, USA. Sept. 22-23, 2016.
Teijido O, Carril JC, Cacabelos. Risk polymorphisms associated with lipid metabolism and vascular risk in the Spanish population. 4th International Conference on Predictive, Preventive, and Personalized Medicine and Molecular Diagnosis, Phoenix, Arizona, USA. Sept. 22-23, 2016.
Carril JC, Teijido O, Cacabelos R. The intelligent pharmacogenetic test. 4th International Conference on Predictive, Preventive, and Personalized Medicine and Molecular Diagnosis, Phoenix, Arizona, USA. Sept. 22-23, 2016.
Carril JC, Teijido O, Cacabelos R. Neuro-PGxCard: A new approach to the personalized treatment of CNS disorders. 4th International Conference on Predictive, Preventive, and Personalized Medicine and Molecular Diagnosis, Phoenix, Arizona, USA. Sept. 22-23, 2016.
Tellado I, Carril JC, Teijido O, Fraile C, Cacabelos R. APOE-related brain hemodynamics. 4th International Conference on Predictive, Preventive, and Personalized Medicine and Molecular Diagnosis, Phoenix, Arizona, USA. Sept. 22-23, 2016.
Cacabelos R, Carril JC, Teijido O. Major determinants of pharmacogenetic response in Alzheimer’s Disease. 4th International Conference on Predictive, Preventive, and Personalized Medicine and Molecular Diagnosis, Phoenix, Arizona, USA. Sept. 22-23, 2016.
Cacabelos R, Carril JC, Teijido O, Fernández-Novoa L, Carrera I. E-PodoFavalin-15999 (Atremorine®): A new modality of nutrigenomic intervention in Parkinson’s Disease. 4th International Conference on Predictive, Preventive, and Personalized Medicine and Molecular Diagnosis, Phoenix, Arizona, USA. Sept. 22-23, 2016.
Cacabelos R. Pentagenic haplotype-related cholesterolemic phenotype in Alzheimer´s disease. Human Genet Embryol 2016; 6(3):20.
Cacabelos R. Genotype-related vascular phenotype in dementia: Impact on the pharmacogenetic outcome. Human Genet Embryol 2016; 6(3):41.
Tellado I, Carril JC, Fraile C, Cacabelos R. Effect of ACE genotype on brain bioactivity in Vascular Dementia. Human Genet Embryol 2016; 6(3):49.
Tellado I, Carril JC, Fraile C, Cacabelos R. Influence of the APOE4 allele on brain networks in healthy elderly subjects. Human Genet Embryol 2016; 6(3):52.
Fernandez-Novoa L, Tellado I, Corzo L, Seoane S, Carrera I, Carril JC, Cacabelos R. A genomic approach to histamine function. Human Genet Embryol 2016; 6(3):57.
Carrera I, Fernandez-Novoa L, Sampedro C, Seoane S, Tellado I, Lakshmana M, Cacabelos R. Validation and characterization of 3xTg (APP/Bin1/COPS5) mice as a new neuropathological model of Alzheimer’s disease. Human Genet
Embryol 2016; 6(3):59.
Corzo L, Rodriguez S, Carril JC, Tellado I, Cacabelos R. Vascular Risk Polymorphisms and Serum Atherogenic Biomarkers. Human Genet Embryol 2016; 6(3):60.
Carril JC, Tellado I, Cacabelos R. Predictive Genetic Risk Test in Cerebrovascular Disorders. Human Genet Embryol 2016; 6(3):61.
Teijido O, Carril JC, Tellado I, Cacabelos R. Epigenomic profile in dementiarelated disorders. Human Genet Embryol 2016; 6(3):62.
Carrera I, Fernandez-Novoa L, Tellado I, Vigo C, Cacabelos R. EB101 vaccine as a dual immunotherapy for preventing and treating Alzheimer´s disease.
Human Genet Embryol 2016; 6(3):63.
CACABELOS R. Pharmacogenetics of Alzheimer’s disease: The critical role of the APOE-TOMM40 region. J Pharmacogenomics Pharmacoproteomics 2016; 7(4): 18.
TEIJIDO O, CARRIL JC, CACABELOS R. Risk polymorphisms associated with lipid metabolism and vascular risk in the Spanish population. J Pharmacogenomics Pharmacoproteomics 2016; 7(4): 48.
CARRIL JC, CACABELOS R. Neuro-PGx Card: A new approach to the personalized treatment of CNS disorders. J Pharmacogenomics Pharmacoproteomics 2016; 7(4): 49.
CARRIL JC, TELLADO I, FRAILE C, CACABELOS R. Impact of rs699 and rs4762 AGT SNPs on functional networks in Vascular Dementia. J Pharmacogenomics Pharmacoproteomics 2016; 7(4): 50.
CARRIL JC, CACABELOS R. Nutrigenomic Card: The Nutrigenetic Risk Test. J Pharmacogenomics Pharmacoproteomics 2016; 7(4): 51.
CARRIL JC, FERNANDEZ-NOVOA L, CORZO L, SEOANE S, CARRERA I, TEIJIDO O, CACABELOS R. A genomic approach to histamine function. J Pharmacogenomics Pharmacoproteomics 2016; 7(4): 52.

2015

Cacabelos R. Pharmacogenetics of psychotropic drugs: The UCJC pharmacogenetic card for personalized treatment. WPA Regional Congress, Osaka International Convention Center, Osaka, Japan, 4-6 June, 2015.

2014

Cacabelos, R. TOMM40 Poly-T variants modify the pharmacogenetic response to conventional treatment in Alzheimer’s disease. 7th Santorini Conference. Biologie Prospective Systems Medicine, Personalized Health and Therapy. 25-27 September, Santorini, Greece (2014).

Torrellas, C., Carril., J.C., Cacabelos. Pharmacogenetics of Antidepressant drugs: Optimizing prescription. 7th Santorini Conference. Biologie Prospective
Systems Medicine, Personalized Health and Therapy. 25-27 September, Santorini, Greece (2014).

Corzo, L., Rodríguez, S., Carril, J.C., Cacabelos, R. Relationships between Genetic Vascular Risk Polymorphisms and Serum Vascular Biomarkers. 7th Santorini Conference. Biologie Prospective Systems Medicine, Personalized Health and Therapy. 25-27 September, Santorini, Greece (2014).

Corzo, L., Carril, J.C., Rodríguez, S., Couceiro, V., Cacabelos, R. Vascular Risk Factors in Dementia: Influence of APOE, MTHFR, NOS3, PSEN1 and ACE Polymorphisms and Association with Cognitive Function Scores. 7th Santorini Conference. Biologie Prospective Systems Medicine, Personalized Health and Therapy. 25-27 September, Santorini, Greece (2014).

Carril., J.C., Cacabelos., R. Atherogenic biomarkers in vascular dementia: the role of inflammation in neurodegeneration. 7th Santorini Conference. Biologie Prospective
Systems Medicine, Personalized Health and Therapy. 25-27 September, Santorini, Greece (2014).

2013

Corzo, L., Rodríguez, S., Cacabelos. Novel vascular risk factor evaluation can improve the prediction and prevention of vascular risk in dementia. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-07-009 (2013).

Corzo, L., Rodríguez, S., Fernández-Novoa, L., Couceiro, V., Cacabelos, R. Vascular risk factors in dementia: Influence of APOE, MTHFR, NOS3, PSEN1 and ACE polymorphisms and association with cognitive function scores. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-07-015 (2013).

Cacabelos, R. Influence of pleiotropic genes in CNS Pharmacogenomics. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, S-048-004 (2013).

Fernández-Novoa, L., Seoane, S., Carril, J.C., Agúndez, J.A., Cacabelos, R. G2019S mutation in sporadic and familial Parkinson’s disease. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-10-004 (2013).

Fernández-Novoa, L., Lombardi, V., Etcheverría, I., Cacabelos, R. The effects of acute and chronic psychological stress on immune function in a rat model. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-12-016 (2013).

Carril, J.C., Corzo, L., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Characterization of the genomic risk profile in cerebrovascular diseases. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-13-022 (2013).

Carril, J.C., Torrellas, C., Fraile, C., Fernández-Novoa, L., Cacabelos, R. Error rate in antidepressant Drug prescription: the importance of personalized medicine. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-18-005 (2013).

Carril, J.C., Torrellas, C., Fraile, C., Fernández-Novoa, L., Cacabelos, R. Pharmacogenetics as a predictive tool to reduce errors in the administration of anxiolytics, hypnotics and sedatives. WFSBP Congress, 11th World Congreso of Biological Psychiatry, 23-27 June, Kyoto, P-18-006 (2013).

Carril, J.C., Fraile, C., Torrellas, C., Couceiro, V., Fernández-Novoa, L., Cacabelos, R. The importance of pharmacogenetics in the treatment of psychotic disorders. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-18-009 (2013).

Carril, J.C., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Characterization of CYP3A polymorphisms in the Spanish population. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-18-015 (2013).

Tellado, I., Corzo, L., Canuet, L., Couceiro, V., Fraile, C., Cacabelos, R. Age-related changes in brain networks: A bioelectrical source localization and functional connectivity study in resting state. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-20-003 (2013).

Canuet, L., Tellado, I., Couceiro, V., Fraile, C., Fernández-Novoa, L., Ishii, R., Takeda, M., Cacabelos, R. Phenotypic profile of brain functional connectivity and oscillatory activity in Alzheimer’s disease. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-21-010 (2013).

Canuet, L., Tellado, I., Corzo, L., Fernández-Novoa, L., Fraile, C., Torrellas, C., Ishii, R., Takeda, M., Cacabelos, R. Association of APOE genotype and LDL-cholesterol levels with brain electrical activity in Alzheimer’s disease. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-21-011 (2013).

Canuet, L., Ishii, R., Pascual-Marqui,M., Iwase, M., Takeda, M., Cacabelos, R., del Pozo, F., Maestu, F. Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy and Alzheimer’s disease using eLORETA. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-84-002 (2013).

Cacabelos, R. Pharmacogenomics of lipid metabolism dysfunction in dementia. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, S-100-004 (2013).

Fernández-Novoa, L., Tellado, I., Canuet, L., Couceiro, V., Fraile, C., Cacabelos, R. Impact of APOE-4 allele on brain activity in aging. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-26-004 (2013).

Fernández-Novoa, L., Carril, J.C., Seoane, S., Cacabelos, R. An association study between histamine and polymorphisms in immune system genes in mental disorders. WFSBP Congress, 11th World Congress of Biological Psychiatry, 23-27 June, Kyoto, P-28-025 (2013).

Cacabelos, R. APOE-TOMM40 and CYP2D6 in the Pharmacogenomics of dementia. European Society of Pharmacogenomics and Theranostics ESPT-2013. Second Conference. Pharmacogenomics: From Cell to Clinic. Sept 26-28, Lisbon, Portuga (2013).

Carril, J.C., Cacabelos, R. Characterization of CYP3A polymorphisms in the Spanish population. European Society of Pharmacogenomics and Theranostics ESPT-2013. Second Conference. Pharmacogenomics: From Cell to Clinic. Sept 26-28, Lisbon, Portugal (2013).

Carril, J.C., Corzo, L., Fernández-Novoa, L., Seoane, S., Cacabelos. Characterization of the genomic risk profile in cerebrovascular diseases. European Society of Pharmacogenomics and Theranostics ESPT-2013. Second Conference. Pharmacogenomics: From Cell to Clinic. Sept 26-28, Lisbon, Portugal (2013).

Torrellas, C., Fraile, C., Carril, J.C., Fernández-Novoa, L., Cacabelos, R. Error rate in antidepressant Drug prescription: the importance of personalized medicine. European Society of Pharmacogenomics and Theranostics ESPT-2013. Second Conference. Pharmacogenomics: From Cell to Clinic. Sept 26-28, Lisbon, Portugal (2013).

Torrellas, C., Piñeiro, S., Villanueva, M.J., Solveira, C., Fraile, C., Carril, J.C., Fernández-Novoa, L., Cacabelos, R. Hypertension management: benefits of pharmacogenetics. European Society of Pharmacogenomics and Theranostics ESPT-2013. Second Conference. Pharmacogenomics: From Cell to Clinic. Sept 26-28, Lisbon, Portugal (2013).

Torrellas, C., Fraile, C., Carril, J.C., Fernández-Novoa, L., Cacabelos, R. Pharmacogenetics as a predictive tool to reduce errors in the administration of anxiolytics, hypnotics and sedatives. European Society of Pharmacogenomics and Theranostics ESPT-2013. Second Conference. Pharmacogenomics: From Cell to Clinic. Sept 26-28, Lisbon, Portugal (2013).

Carril, J.C., Fraile, C., Torrellas, C., Couceiro, V., Fernández-Novoa, L., Cacabelos, R. The importance of pharmacogenetics in the treatment of psychotic disorders. European Society of Pharmacogenomics and Theranostics ESPT-2013. Second Conference. Pharmacogenomics: From Cell to Clinic. Sept 26-28, Lisbon, Portugal (2013).

2012

Cacabelos, R. ¿Se puede prevenir la enfermedad de Alzheimer? IX Jornadas de Actualización en Vacunas. Vacunas para una salud global. Salón de Actos Casa de las Mariposas, Almería, 1-2 Octubre (2012).

Cacabelos, R. Farmacogenómica y vacuna anti-Alzheimer. XXXI Lección Memorial. Visión crítica de la prevención cardiovascular: focalizándose en los factores determinantes del envejecimiento saludable. Fundación Fernández-Cruz. Auditorio del Hospital Clínico San Carlos, Madrid, 26 Nov (2012).

Cacabelos, R. Genomics and Pharmacogenomics of neurodegeneration. Longeva. Congresso Internazionale ECM. Medicina preventiva, predittiva e rigenerativa. Fiera Milano Rho, Milán, 30 Nov- 1 Dic (2012).

Aliev, G., Bragin, V., Cacabelos, R. Implication of integrative treatment for real-life geriatric patients with depression, dementia and multiple chronic diseases: A 60-month follow-up of a naturistic study. 5th Clinical Trial son Alzheimer’s disease (CTAD) Conference. Montecarlo, France, Oct 29-31 (2012). J Nutrition Health Ageing 16:840-841 (2012).

2011

Cacabelos, R. Nutrigenómica y farmacogenómica: de la teoría a la práctica. VII Congreso Internacional de Nutrición, Alimentación y Dietética. XV Jornadas Nacionales de Nutrición Práctica. Sociedad Española de Dietética y Ciencias de la Alimentación. Universidad Complutense, Madrid, 30-31 Marzo- 1 Abril, 2011. Revista de Nutrición Práctica 15:9-10 (2011).

Cacabelos, R. Functional genomics and pharmacogenomics of CNS disorders. 10th World Congress of Biological Psychiatry, pp. 100, Prague, 29 May – 2 June, 2011.

Fernández-Novoa, L., Cacabelos, R. APOE and CYP2D6 in CNS disorders. European Human Genetics Conference 2011, Amsterdam, 28-31 May, 2011. Eur J Hum Genet 19 (Suppl. 2):284 (2011).

Fernández-Novoa, L., Carril, J., Seoane, S., Cacabelos, R. Characterization of the genomic risk profile in cerebrovascular diseases. European Human Genetics Conference 2011, Amsterdam, 28-31 May, 2011. Eur J Hum Genet 19 (Suppl. 2):290 (2011).

Fernández-Novoa, L., Seoane, S., Carril, J., García-Agúndez, J.A., Cacabelos, R. LRRK2 mutations in sporadic and familial Parkinson disease. European Human Genetics Conference 2011, Amsterdam, 28-31 May, 2011. Eur J Hum Genet 19 (Suppl. 2):300 (2011).

Cacabelos, R. Pharmacogenomics of schizophrenia and lipid metabolism alterations in CNS disorders. 3rd World Congress of Asian Psychiatry 2011. Melbourne, 31 July – 4 August, 2011. Asian Journal of Psychiatry 4(Suppl. 1): 11 (2011).

Cacabelos, R., Sánchez, J. Introduction to the World Guide of Pharmacogenomics. VI Conferencia Annual EuroEspes, Gen-T 8:34-35 (2011).

Carril, J.C., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Caracterización del perfil genético de riesgo cerebrovascular. VI Conferencia Annual EuroEspes, Gen-T 8:88 (2011).

Carril, J.C., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Citoquinas proinflamatorias polimórficas como marcadores genéticos de aterosclerosis. VI Conferencia Annual EuroEspes, Gen-T 8:88-89 (2011).

Canuet, L., Tellado, I., Couceiro, V., Fraile, C., Cacabelos, R. Perfil fenotípico EEG de conectividad funcional y actividad oscilatoria en la enfermedad de Alzheimer. VI Conferencia Annual EuroEspes, Gen-T 8:89-90 (2011).

Canuet, L., Tellado, I., Corzo, L., Fraile, C., Cacabelos, R. Relación del genotipo APOE y niveles séricos de LDL-colesterol con la actividad bioeléctrica cerebral en pacientes con enfermedad de Alzheimer. VI Conferencia Annual EuroEspes, Gen-T 8:90 (2011).

Corzo, L., Lombardi, V., Alejo, R., Rodríguez, S., Cacabelos, R. Bioproperties and clinical effects of Juritrofin (DefenVid®). VI Conferencia Annual EuroEspes, Gen-T 8:91-92 (2011).

Corzo, L., Rodríguez, S., Alejo, R., Cacabelos, R. Biological properties of Mineraxin. VI Conferencia Annual EuroEspes, Gen-T 8:92 (2011).

Fernández-Novoa, L., Corzo, L., Seoane, S., Carril, J.C., Cacabelos, R. A genomic approach to histamine function. VI Conferencia Annual EuroEspes, Gen-T 8:93-94 (2011).

Fernández-Novoa, L., Cacabelos, R. Histamine function in brain disorders. VI Conferencia Annual EuroEspes, Gen-T 8:94 (2011).

Lombardi, V.R.M., Carrera, I., Etcheverría, I., Martínez, E., Chacón, R., Cacabelos, R. Prevención de colitis experimental crónica inducida por dextrán sulfato sódico (DSS) en ratones tratados con FR-91. VI Conferencia Annual EuroEspes, Gen-T 8:94-95 (2011).

Lombardi, V.R.M., Alejo, R., Etcheverría, I., Pablos, A., Cacabelos, R. Testaje experimental de las propiedades de bioproductos en preparados de Alimentos Naturales, S.A. VI Conferencia Annual EuroEspes, Gen-T 8:95 (2011).

Tellado, I., Canuet, L., Couceiro, V., Fraile, C., Cacabelos, R. Cambios en la actividad bioeléctrica cerebral durante el envejecimiento y el deterioro cognitivo. VI Conferencia Annual EuroEspes, Gen-T 8:95-96 (2011).

Tellado, I., Canuet, L., Fraile, C., Cacabelos, R. Influencia del alelo APOE-4 sobre la función cerebral en ancianos sanos. VI Conferencia Annual EuroEspes, Gen-T 8:96 (2011).

2010

Cacabelos, R. Nutrigenomic component of marine biotechnology products for human Health. 239th American Chemical Society National Meeting & Exposition. San Francisco, USA, March 21-25, pp. TECH-58 (2010).

Cacabelos, R. Farmacogenética de la enfermedad de Alzheimer. XXXIII Congreso Nacional de Farmacología para Estudiantes. Universidad Autónoma de Madrid, Madrid, 4-5 Mayo, 2010.

Cacabelos, R., Avramopoulos, Baskys, A., Cai, Y. Genetic testing in neuropsychiatry: APOE and beyond. 10th Annual Meeting of the International College of Geriatric Psychoneuropharmacology. The Divani Palace Acropolis Hotel, Athens, 15-18 September, 2010.

Cacabelos, R. Genomics and pharmacogenomics of psychotic disorders. VII Congress of the Polish Society of Psychogeriatrics. Wroclaw, 2-3 December, 2010.

2009

Álvarez, A., Cacabelos, R., Aleixandre, M., Linares, C., Granizo, E., Doppler, E., Moessler, H. Double-blind clinical trial with cerebrolysin, donepezil and a combination therapy in mild to moderate Alzheimer’s disease. Second Joint Congress of GCNN and SSNN. Vienna, 1-3 March (2009).

Cacabelos, R. Pharmacogenomic protocols in CNS disorders and dementia. 9th International Conference AD/PD 2009, Prague, March 11-15, p. 18 (2009).

Corzo, L., Rodríguez, S., Fernández-Novoa, L., Laredo, M., Cruceiro, V., Cacabelos, R. Influence of vascular risk factors on cognitive status. 9th International Conference AD/PD 2009, Prague, March 11-15, p. 105 (2009).

Fernández-Novoa, L., Seoane, S., Llovo, R., Tudoli, I., Corzo, L., Cacabelos, R. Polygenic risk factors in Alzheimer disease: Calculation of a genetic predisposition store (GPS). 9th International Conference AD/PD 2009, Prague, March 11-15, p. 147 (2009).

Carril, J.C., Fernández-Novoa, L., Llovo, R., Cacabelos, R. Logistic regression as a useful tool to explain genetic risk of stroke. 9th International Conference AD/PD 2009, Prague, March 11-15, p. 154 (2009).

Fernández-Novoa, L., Llovo Mariño, R., Tudoli, S., Seoane, S., Cacabelos, R. 9th International Conference AD/PD 2009, Prague, March 11-15, p. 155 (2009).

Álvarez, A., Sampedro, C., Corzo, L., Cacabelos, R., Aleixandre, M., Vargas, M., Linares, C., Granizo, E. Modulatory effects of cerebrolysin on TNF-alpha and IGF.I in Alzheimer’s disease. 9th International Conference AD/PD 2009, Prague, March 11-15, p. 200 (2009).

Fernández-Novoa, L., Etcheverría, I., Seoane, S., Cacabelos, R., Lombardi, V. Immune studies in peripheral blood of patients with Alzheimer’s disease. 9th International Conference AD/PD 2009, Prague, March 11-15, p. 206 (2009).

Álvarez, A., Sampedro, C., Cacabelos, R. Inflammatory biomarkers are associated with low IGF-I levels and disability in Alzheimer’s disease. 9th International Conference AD/PD 2009, Prague, March 11-15, p. 208 (2009).

Álvarez, A., Sampedro, C., Cruceiro, V., Cacabelos, R., Aleixandre, M., Vargas, M., Linares, C., Granizo, E., Doppler, E., Novak, P., Moessler, H. Cerebrolysin, donepezil and a combination therapy in Alzheimer’s disease: Results of a double-blind clinical trial. 9th International Conference AD/PD 2009, Prague, March 11-15, p. 231 (2009).

Cacabelos, R. Cáncer y enfermedades neurodegenerativas (Ende) como opuestos metabólicos ácido-básicos. Enfoque genético y factores de crecimiento en etiopatogenia y tratamiento. International Symposium. Transporte de protones y su inhibición (ITP) en la etiopatogenia, diagnóstico y tratamiento del cáncer. Fundación Ramón Areces, Madrid, 28-29 Abril (2009).

Takeda, M., Shibata, N., Kim, D.K., Cacabelos, R. Pharmacogenomics and nutrigenomics in CNS disorders of the elderly. IPA 2009 International Meeting. Brain Aging and Quality of Life, Rio de Janeiro, Brazil, 4-7 May, (2009).

Cacabelos, R. Genomic mechanisms of neurodegeneration: implications for pharmacogenomics and nutrigenomics. The Second Annual Iberian Congress on Anti-Aging Medicine and Biomedical Technologies. Vilamoura-Algarve, Portugal, June 4-6, (2009).

Álvarez, A., Sampedro, C., Cacabelos, R., Novak, P., Moessler, H. Opposite effects of cerebrolysin on serum TNF-alpha and IGF-I levels in Alzheimer’s disease. Alzheimer’s Association 2009 International Conference on Alzheimer’s Disease (ICAD). Vienna, 11-16 July (2009).

Álvarez, A., Sampedro, C., Cacabelos, R. Overexpression of inflammation markers in Alzheimer’s disease: Clinical correlates. Alzheimer’s Association 2009 International Conference on Alzheimer’s Disease (ICAD). Vienna, 11-16 July (2009).

Cacabelos, R. Biomarkers and pharmacogenomics. Alzheimer’s Association 2009 International Conference on Alzheimer’s Disease (ICAD). Vienna, 11-16 July (2009).

Cacabelos, R. Conferencia Inaugural. III Congreso Internacional sobre Tratamientos Complementarios y Alternativos en Cáncer. World Association for Cancer Research, Madrid, 31 Oct-1 Nov. (2009).

Álvarez, X.A., Sampedro, C., Cacabelos, R. Clinical relevance of peripheral inflammatory biomarkers in Alzheimer’s disease and vascular dementia. Sixth International Congress on Vascular Dementia, Barcelona, 19-22 Nov. (2009).

Cacabelos, R. Medicina personalizada en el abordaje clínico de la demencia: Farmacogenómica de la enfermedad de Alzheimer. IV Conferencia Anual EuroEspes. Avances en Medicina Genómica, Coruña, Dic. 19 (2009).

2008

Álvarez, A., Sampedro, C., Couceiro, V., Cacabelos, R., Doppler, E., Hitzl, M., Moessler, H. Cerebrolysin in moderate to moderately severe Alzheimer disease: Efficacy and safety analysis in a subgroup of a double-blind, placebo-controlled trial. Alzheimer’s Association International Conference on Alzheimer’s Disease (ICAD). Chicago, July 26-31 (2008).

Álvarez, A., Sampedro, C., Cacabelos, R., Linares, C., Granizo, E., Aleixandre, M., Moessler, H. Cerebrolysin reduces TNF-alpha and soluble TNF receptor-1 levels in the serum of Alzheimer disease patients. Alzheimer’s Association International Conference on Alzheimer’s Disease (ICAD). Chicago, July 26-31 (2008).

Álvarez, A., Sampedro, C., Cacabelos, R., Linares, C., Granizo, E., Aleixandre, M., García-Fantini, M. Hyperactivity of peripheral TNF-alpha system in Alzheimer’s disease: Interaction with serum IGF-1. Alzheimer’s Association International Conference on Alzheimer’s Disease (ICAD). Chicago, July 26-31 (2008).

Cacabelos, R. Manejo práctico de la farmacogenética en niños y adultos. Jornadas Médicas, Hospital Español, México DF, Febrero 16 (2008).

Álvarez, A., Sampedro, C., Cacabelos, R., Linares, C., Granizo, E., Aleixandre, M., García-Fantini, M. Hyperactivity of peripheral TNF-alpha system in Alzheimer’s disease: Interaction with serum IGF-I. Alzheimer’s Association International Conference on Alzheimer’s Disease. July 26-31. Alzheimer’s & Dementia, 4(Suppl.2):T137 (2008).

Álvarez, A., Sampedro, C., Cruceiro, V., Cacabelos, R., Aleixandre, M., Doppler, E., Moessler, H. Cerebrolysin in moderate to moderately severe Alzheimer’s disease: a subgroup analysis of efficacy and safety data. 12th Congress of the European Federation of Neurological Societies, Madrid, August 23-26. Eur. J. Neurol., 15(Suppl.3):24 (2008).

Cacabelos, R. Pharmacogenomics in CNS Disorders. 51st Annual Meeting of the Japanese Society of Neurochemistry, Sept. 11. Bull. Jap Soc Neurochem., 47: 210 (2008).

Cacabelos, R. Genotype-related phenotypic expression of biomarkers in dementia: Implications for pharmacogenomics. World Federation of Societies of Biological Psychiatry. 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP. 11-13 Sept. The World Journal of Biological Psychiatry, Vol. 9(Suppl.1):82 (2008).

Cacabelos, R. Farmacogenómica en las enfermedades neurológicas. XXXII Reunión Anual Academia Mexicana de Neurología. Puerto Vallarta, 25 Oct. – 1 Nov. (2008).

Cacabelos, R. Genomic medicine and pharmacogenomics of neuropsychiatric disorders. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:26-29 (2008).

Harguindey S, Díaz de Otazu, R., Arlueca, J., Catalán, J., Arranz, J.L., Orive, G., Reshkin, S.J., Cacabelos, R. Human neurodegenerative diseases (hndds) and cancer: an integral approach to the etiopathogenesis and treatment of hndds within the frame of the trophic factor withdrawal syndrome (TFWS). III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:66 (2008).

Martínez, E., Chacón, R., Etcheverría, I., Cacabelos, R., Lombardi, V.R.M. Cytotoxicity effects induced by FR-91 on human tumor cell lines. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:68 (2008).

Martínez, E., Chacon, R., Cacabelos, R., Etcheverría, I., Lombardi, V.R.M. Effects of FR-91 on immune cells from healthy individuals and patients with non-Hodgkin lymphoma. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:68 (2008).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Caspase 3 activity in PBMCs from Alzheimer’s disease patients: when and why do cells die? III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:69 (2008).

Des, J., Pérez, R., Alcaraz, M., Nebril, L., Fernández-Novoa, L., Cacabelos, R. ACE-related blood pressure values in the Spanish population. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:69-70 (2008).

Des, J., Pérez, R., Alcaraz, M., Nebril, L., Fernández-Novoa, L., Cacabelos, R. ACE-related brain hemodynamic parameters in the Spanish population. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:70 (2008).

Pérez, R., Des, J., Fraile, C., Fernández-Novoa, L., Corzo, L., Cacabelos, R. FOS-related blood biochemical parameters and brain hemodynamics in the Spanish population. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:70 (2008).

Pérez, R., Des, J., Fraile, C., Fernández-Novoa, L., Corzo, L., Cacabelos, R. APOE-related blood biochemical parameters and brain hemodynamics in the Spanish population. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:71 (2008).

Aguilar Aldrete, M.E., Moran Moguel, M.C., Sandoval-Ramírez, L., Rosales-Gómez, R.C., Gutiérrez-Rubio, S.A., Rodríguez-Vega, M.C., Parra Bernal, M.C., Cacabelos, R. Comparative study of APOE polymorphisms in the Mexican population: Alzheimer’s disease vs. Indians and mestizos. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:74 (2008).

Álvarez, A., Cacabelos, R., Mandler, M., Mattner, F. Mimovax: A novel approach for a safe vaccine for Alzheimer’s disease. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:75 (2008).

Fraile, C., Martínez, R., Cacabelos-Pérez, N., Corzo, L., Fernández-Novoa, L., Cacabelos-Pérez, R., Cacabelos, R. Presenilin-related biochemical and brain hemodynamic parameters in patients with Alzheimer’s disease. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:75-76 (2008).

Fraile, C., Llovo, R., Martínez, R., Cacabelos-Pérez, N., Corzo, L., Fernández-Novoa, L., Cacabelos-Pérez, R., Cacabelos, R. CYP2D6-related biochemical and brain hemodynamic parameters in patients with Alzheimer’s disease. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:76 (2008).

Martínez, R., Cacabelos-Pérez, N., Cacabelos-Pérez, R., Cacabelos, R. CYP genes and drug metabolism: major substrates for antidepressants, neuroleptics and benzodiazepines. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:76-77 (2008).

Llovo, R., Tudoli, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Genetic polymorphisms of Cytochrome P450: CYP2D6, CYP2C19, CYP2C9 and CYP3A5 in the Spanish population. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:77 (2008).

Llovo, R., Fernández-Novoa, L., Seoane, S., Tudoli, I., Cacabelos, R. Pharmacogenetic patterns of CYP2C9 and VKORC1 in the Spanish population. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:78 (2008).

Corzo, L., Rodríguez, S., Cacabelos, R. Important role of novel vascular risk factors to decrease vascular risk in patients with dementia. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:78-79 (2008).

Carril, J.C., Tudoli, I., Cacabelos, R. IL-6 and IL-6R gene polymorphisms and risk of stroke and neurodegeneration. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:79 (2008).

Carril, J.C., Llovo, R., Fernández-Novoa, L., Cacabelos, R. Logistic regression as a useful tool to explain genetic risk of stroke. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:79 (2008).

Fernández-Novoa, L., Seoane, S., Llovo, R., Tudoli, I., Cacabelos, R. Vascular genetic risk factors in Alzheimer’s disease. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:80 (2008).

Tellado, I. Cacabelos, R. Effect of ACE genotype on brain bioelectrical activity. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:80 (2008).

Fernández-Novoa, L., Seoane, S., Llovo, R., Tudoli, I., Corzo, L., Cacabelos, R. Polygenic risk factors related to neurodegeneration in Alzheimer’s disease: calculation of a genetic predisposition store (GPS). III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:90-81 (2008).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Chronic activation of PBMCS in Alzheimer’s disease patients. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:81 (2008).

Corzo, L., Rodríguez, S., Fernández-Novoa, L., Laredo, M., Cruceiro, V., Cacabelos, R. Association of novel vascular risk factors and cognitive function in dementia. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:82 (2008).

Tellado, I., Cacabelos, R. Impact of APOE genotype on brain bioelectrical activity. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:82-83 (2008).

Tellado, I., Fraile, C., Cacabelos, R. Influence of APOE genotype on brain function as assessed by Optical Topography. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:83 (2008).

Laredo, M., Couceiro, V., Álvarez, A., Sampedro, C., Cacabelos, R. Neuropsychiatric symptoms and APOE-4 in cognitively impaired patients. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:84 (2008).

Álvarez, A., Sampedro, C., Corzo, L., Cacabelos, R. Immuno-trophic regulation in Alzheimer’s disease: TNF-ALPHA/IGF-I interactions. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:84 (2008).

Martínez, R., Alejo, R., Lombardi, V., Fernández-Novoa, L., Corzo, L., Alcaraz, M., Nebril, L., Casas, A., Fraile, C., Vallejo, A., Cacabelos, R. Nutraceutical properties of E-SAR-94010 (LipoEsar®): APOE-related nutrigenomic profile. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:85 (2008).

Martínez, R., Fraile, C., Cacabelos-Pérez, N., Cacabelos-Pérez, R., Fernández-Novoa, L., Corzo, L., Lombardi, V., Tellado, I., Pérez, R., Laredo, M., Cruceiro, V., Álvarez, A., Des, J., Cacabelos, R. APOE-related phenotypic profile in Alzheimer’s disease and vascular dementia. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:85-89 (2008).

Llovo, R., Fernández-Novoa, L., Tudoli, I., Vallejo, A., Cacabelos, R. Genetic polymorphisms of several genes associated with key metabolic pathways in obesity. III EuroEspes Annual Conference, 1st Meeting World Association of Genomic Medicine, Coruña, Dec. 12-13 (2008). Gen-T/The EuroEspes Journal (International Edition) 2:89-90 (2008).

2007

Cacabelos, R. Pharmacogenomics and therapeutic prospects in dementia. Pharmainnovation. Pharmaceutical Innovation. Bonn, 11-12 June (2007).

Álvarez, X.A., Linares, C., Aleixandre, M., Cacabelos, R., Hitzl, M. Tratamiento neurotrófico en la enfermedad de Alzheimer: Mecanismos moleculares y estudios clínicos. XII Congreso Panamericano de Neurología. Santo Domingo, 7-11 Oct. pp. 16 (2007).

Álvarez, X.A., Sampedro, C., García-Fantini, M., Linares, C., Aleixandre, M., Cacabelos, R., Hitzl, M. Interacción funcional entre TNF-alfa e IGF-I en la enfermedad de Alzheimer: Implicaciones patogénicas y terapéuticas. XII Congreso Panamericano de Neurología. Santo Domingo, 7-11 Oct. pp. 51-52 (2007).

Álvarez, X.A., Sampedro, C., Cacabelos, R., Moessler, H. Interaction between TNF-alpha and IGF-I in Alzheimer disease: Pathogenic and therapeutic implications. 8th International Conference AD/PD, Salzburg, Austria, March 14-18. Neurodegenerative Dis., 4(Suppl.1): 334 (2007).

Cacabelos, R. Influence of pharmacogenetic factors on Alzheimer’s disease. Therapeutics. 8th International Conference AD/PD, Salzburg, Austria, March 14-18. Neurodegenerative Dis., 4(Suppl.1): 4 (2007).

Fernández-Novoa, L., Llovo, R., Seoane, S., Bello, A., Rey, P., Corzo, L., Cacabelos, R. Cholesteryl ester transfer protein (CETP) gene and cholesterol metabolism in dementia. 8th International Conference AD/PD, Salzburg, Austria, March 14-18. Neurodegenerative Dis., 4(Suppl.1): 119 (2007).

Isaza, C., Henao, J., Llovo, R., Fernández-Novoa, L., Cacabelos, R. Similar pharmacogenetic patterns of CYP2C19 in Spanish and Colombian populations. 8th International Conference AD/PD, Salzburg, Austria, March 14-18. Neurodegenerative Dis., 4(Suppl.1): 138 (2007).

Isaza, C., Henao, J., Llovo, R., Fernández-Novoa, L., Cacabelos, R. CYP2D6 in the Spanish population with dementia. 8th International Conference AD/PD, Salzburg, Austria, March 14-18. Neurodegenerative Dis., 4(Suppl.1): 138 (2007).

Corzo, L., Fernández-Novoa, L., Rodríguez, S., Cacabelos, R. Vascular risk factors and endothelial NOS3 polymorphism variants in Alzheimer’s disease. 8th International Conference AD/PD, Salzburg, Austria, March 14-18. Neurodegenerative Dis., 4(Suppl.1):143-144 (2007).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Lymphocyte subset markers and cytokine production in peripheral blood of patients with AD. 8th International Conference AD/PD, Salzburg, Austria, March 14-18. Neurodegenerative Dis., 4(Suppl.1):229 (2007).

Cacabelos, R. La medicina genómica en las enfermedades degenerativas y el cáncer. II Congreso Internacional sobre Tratamientos Complementarios y Alternativos en Cáncer. Madrid, 26 Mayo (2007).

Cacabelos, R. Pharmacogenetics and therapeutic optimization in dementia. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):8-9 (2007).

Álvarez, A., Sampedro, C., Cacabelos, R., Moessler, H. Functional interaction of serum tumor necrosis factor-alpha and insulin growth factor-I in Alzheimer’s disease. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):300 (2007).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. IL-1beta, IL-6 and TNF-alpha inflammatory cytokines and lymphocyte subset markers in patients with Alzheimer’s disease (AD). Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):302-303 (2007).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Inflammatory and immune responses in patients with Alzheimer’s disease (AD). Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):303 (2007).

Lombardi, V.R.M., Fernández-Novoa, L., Llovo, R., Seoane, S., Corzo, L., Cacabelos, R. Cholesteryl ester transfer protein (CETP) gene and cholesterol in Alzheimer’s disease. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):303-304 (2007).

Lombardi, V.R.M., Llovo, R., Fernández-Novoa, L., Seoane, S., Henao, J., Cacabelos, R. CYP2D6 in the Spanish population with dementia. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):304 (2007).

Lombardi, V.R.M., Llovo, R., Fernández-Novoa, L., Seoane, S., Henao, J., Cacabelos, R. Similar pharmacogenetic patterns of CYP2C19 in Spanish and Colombian populations. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):304-305 (2007).

Lombardi, V.R.M., Llovo, R., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Genetic polymorphisms of cytochromes P450: CYP2D6, CYP2C19 and CYP2C9 in Spanish population. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):305 (2007).

Corzo, L., Rodríguez, S., Fernández-Novoa, L., Cacabelos, R. Alzheimer’s disease-associated peripheral markers are interrelated to lipid metabolism. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):307 (2007).

Corzo, L., Rodríguez, S., Fernández-Novoa, L., Cacabelos, R. Endothelial NOS3 polymorphism influence on peripheral vascular markers in Alzheimer’s disease. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):307-308 (2007).

Tellado, I., Fraile, C., Cacabelos, R. Brain optical topography in Alzheimer’s disease and vascular dementia. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):308 (2007).

Álvarez, A., Sampedro, C., Cruceiro, V., Cacabelos, R., Aleixandre, M., Moessler, H. Neuropsychiatric symptoms and ApoE-4 in patients with cognitive deterioration: Impact on functioning. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):335-336 (2007).

Tellado, I., Fraile, C., Cacabelos, R. Impact of ApoE genotype on brain function as assessed by optical topography. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):363 (2007).

Tellado, I., Fraile, C., Cacabelos, R. ACE genotype-related changes in brain optical topography. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):363-364 (2007).

Corzo, L., Vallejo, A.I., Antelo, A.M., Lombardi, V., Cacabelos, R. E-JUR-94013; a nutraceutical compound with immunomodulatory effects in the elderly. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):416 (2007).

Tellado, I., Fraile, C., Cacabelos, R. Brain optical topography patterns in stroke, vascular encephalopathy and migraine. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):426 (2007).

Lombardi, V.R.M., Etcheverría, J., Díaz, J., Fernández-Novoa, L., Cacabelos, R. Silver Congress of the International Psychogeriatric Association. Osaka, 14-18 Oct. International Psychogeriatrics, 19(Suppl.1):Add. 5 (2007).

Cacabelos, R. Dementia in Europe: Present and future challenges. Aiming for the Communities Living Together with Dementia – In Japan and the World. Aging and Dementia – the States in Japan and Abroad. Osaka International Convention Center, Osaka, 14 Oct. (2007).

Álvarez X.A., Sampedro, C., Corzo, L., Cacabelos, R. Alterations of serum TNF-alpha and IGF-I levels in vascular dementia. Fifth International Congress on Vascular Dementia. Budapest, Hungary, Nov 8-11 (2007).

Cacabelos, R. Medicina Genómica. Congreso Internacional de Medicina Biológica. Medicina Funcional de Vanguardia. Universidad Autónoma de Guadalajara, Guadalajara, México; 30 Nov., 2007.

Cacabelos, R. Farmacogenómica aplicada a las neurociencias clínicas. II Conferencia Anual EuroEspes, Coruña, Dic. 15 (2007).

2006

Cacabelos, R. Pharmacogenetic aspects of therapy with cholinesterase inhibitors. 9th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. 19-22 April, Geneva, Neurobiol. Aging, 27 (S1): S4 (2006).

Álvarez, A., Laredo, M., Varela, M., Cacabelos, R., Sampedro, C., Aleixandre, M., Linares, C., Moessler, H. Double-blind, placebo-controlled study of three different dosages of cerebrolysin in patients with mild to moderate Alzheimer’s disease. Alzheimer’s Association 10th International Conference on Alzheimer’s Disease and Related Disorders. Madrid, 15-20 July. Alzheimer’s & Dementia, 2(Suppl.1):S364 (2006).

Álvarez, A., Corzo, L., Couceiro, V., Sampedro, C., Cacabelos, R. Cerebrolysin reduces the increased levels of serum tumor necrosis factor-alpha in Alzheimer’s disease. Alzheimer’s Association 10th International Conference on Alzheimer’s Disease and Related Disorders. Madrid, 15-20 July. Alzheimer’s & Dementia, 2(Suppl.1): S370 (2006).

Cacabelos, R. Introducción a la Medicina Genómica en Neurociencias. I Conferencia Anual EuroEspes, Coruña, 15 Dic (2006).

2005

Fernández-Novoa, L., Seoane, S., Lombardi, V., Cacabelos, R. The influence of genotype on blood lipid parameters in Alzheimer’s disease and control subjects. 7th International Conference AD/PD 2005. Alzheimer’s and Parkinson’s diseases: Insights, Progress and Perspectives. Sorrento, March 9-13, pp. 25 (2005).

Álvarez, X.A., Cacabelos, R., Moessler, H. Cerebrolysin: Efficacy and safety in moderate to moderately severe Alzheimer’s disease- A subgroup analysis of a randomized, double-blind, placebo-controlled trial. 7th International Conference AD/PD 2005. Alzheimer’s and Parkinson’s diseases: Insights, Progress and Perspectives. Sorrento, March 9-13, pp. 46 (2005).

Cacabelos, R. Functional genomics and pharmacogenomics of Alzheimer’s disease. 7th International Conference AD/PD 2005. Alzheimer’s and Parkinson’s diseases: Insights, Progress and Perspectives. Sorrento, March 9-13, pp. 56 (2005).

Álvarez, X.A., Corzo, L., Zas, R., Sampedro, C., Cacabelos, R. Serum TNF-alpha in Alzheimer’s disease: Increased levels and negative correlations with IGF-1. 7th International Conference AD/PD 2005. Alzheimer’s and Parkinson’s diseases: Insights, Progress and Perspectives. Sorrento, March 9-13, pp. 120 (2005).

Álvarez, X.A., Sampedro, C., Cruceiro, V., Corzo, L., Cacabelos, R., Aleixandre, M., Vargas, M., Linares, C., Granizo, E., Moessler, H. Double-blind, placebo-controlled study of three doses of cerebrolysin in mild to moderate Alzheimer’s disease. 7th International Conference AD/PD 2005. Alzheimer’s and Parkinson’s diseases: Insights, Progress and Perspectives. Sorrento, March 9-13, pp. 136 (2005).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Alterations of immune functions and lymphocyte apoptosis in patients with Alzheimer’s disease (AD). 7th International Conference AD/PD 2005. Alzheimer’s and Parkinson’s diseases: Insights, Progress and Perspectives. Sorrento, March 9-13, pp. 170 (2005).

Cacabelos, R. Pharmacogenomics studies in Alzheimer’s disease: Genotype-related therapeutic response. Joint Meeting of the 27th Annual Meeting of the Japanese Society of Biological Psychiatry (JSBP) and the 35th Annual Meeting of the Japanese Society of Neuropsychopharmacology (JSNP). Osaka, July 6-8, pp. 15, 2005.

Cacabelos, R. Pharmacogenetics and pharmacogenomics of CNS disorders. Joint Meeting of the 27th Annual Meeting of the Japanese Society of Biological Psychiatry (JSBP) and the 35th Annual Meeting of the Japanese Society of Neuropsychopharmacology (JSNP). Osaka, July 6-8, pp. 93, 2005.

Álvarez, A., Laredo, M., Couceiro, V., Sampedro, C., Cacabelos, R., Illescas, E., Vargas, M. Neuropsychiatric symptoms in Alzheimer’s disease versus mild cognitive impairment. XIII World Congress of Psychiatry, Cairo, Egypt, 10-15 Sept. PO1.P259 (2005).

Álvarez, A., Cacabelos, R., Laredo, M., Varela, M., Sampedro, C., Aleixandre, M., Illescas, E., Linares, C., Granizo, E., Moessler, H. Cerebrolysin in Alzheimer’s disease: a double-blind, placebo-controlled study. XIII World Congress of Psychiatry, Cairo, Egypt, 10-15 Sept. OR22.6 (2005).

Álvarez, A., Laredo, M., Couceiro, V., Sampedro, C., Cacabelos, R., Illescas, E., Aleixandre, M. Neuropsychiatric symptoms in vascular dementia: Comparison with AD and mild cognitive impairment. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Álvarez, X.A., Sampedro, C., Cruceiro, V., García, C., Vargas, M., Cuesta, I., Cacabelos, R., Moessler, H. Cognitive improvement and EEG activation by cerebrolysin in vascular dementia: an exploratory study. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Cacabelos, R., Fernández-Novoa, L., Lombardi, V., Tellado, I., Nebril, L., Casas, A., Alcaraz, M., Pichel, V. Structural genomics studies in vascular dementia (VD) and Alzheimer disease (AD): Differential genomic patterns and genetic variation. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Fernández-Novoa, L., Seoane, S., Corzo, L., Lombardi, V.R.M., Cacabelos, R. Genetic risk factors and lipid parameters in dementia. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Corzo, L., Fernández-Novoa, L., Rodríguez, S., Cacabelos, R. Decreased serum nitric oxide levels in vascular dementia. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Peripheral increases in IL-6, lymphocyte apoptosis and immune activation in patients with dementia. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Pichel, V., Tellado, I., Nebril, L., Casas, A., Alcaraz, M., Varela, M., Cacabelos, R. Disease-specific differences in brain hemodynamics in patients with vascular dementia, Alzheimer’s disease and Parkinson’s disease. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Tellado, I., Pichel, V., Nebril, L., Casas, A., Alcaraz, M., Varela, M., Cacabelos, R. Influence of blood pressure on brain hemodynamics and bioelectrical activity spectral power in vascular dementia, Alzheimer’s disease and Parkinson’s disease. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Tellado, I., Pichel, V., Cacabelos, R. Brain bioelectrical activity spectral power in vascular dementia, Alzheimer’s disease and Parkinson’s disease. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

Pichel, V., Tellado, I., Nebril, L., Casas, A., Alcaraz, M., Varela, M., Cacabelos, R. Age-related brain hemodynamics in vascular dementia, Alzheimer’s disease and Parkinson’s disease. Fourth International Congress on Vascular Dementia, Porto, Portugal, 20-23 Oct (2005).

2004

Cacabelos, R., Lombardi, V., Kubota, Y., Pichel, V., Fernández-Novoa, L. Increased genetic variation in Alzheimer disease (AD) and no apparent influence of the prion M129V polymorphism on AD pharmacogenomics. Human Genome Meeting (HGM-2004). Berlin, April 4-7, 2004; pp. 63.

Fernández-Novoa, L., Corzo, L., Zas, R., Seoane, S., Cacabelos, R. Influence of ACE indel polymorphism on ACE activity and plasma beta-amyloid in dementia. Human Genome Meeting (HGM-2004). Berlin, April 4-7, 2004; pp. 65.

Isaza, C., Henao, J., Fernández-Novoa, L., Cacabelos, R. The drug metabolizer CYP2D6 gene in Alzheimer disease. Human Genome Meeting (HGM-2004). Berlin, April 4-7, 2004; pp. 67.

Lombardi, V.R.M., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Probable Alzheimer disease and alpha-2-macroglobulin polymorphism. Human Genome Meeting (HGM-2004). Berlin, April 4-7, 2004; pp. 70.

Tellado, I., Fernández-Novoa, L., Lombardi, V., Pichel, V., Cacabelos, R. APOE-related phenotypic variation in brain function. Human Genome Meeting (HGM-2004). Berlin, April 4-7, 2004; pp. 75.

Cacabelos, R. Genetic variation, functional genomics and pharmacogenomics in Alzheimer disease. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004. Neurobiol. Aging, 25:S4 (2004).

Álvarez, A., Corzo, L., Sampedro, C., Cacabelos, R. FERUM insulin-like growth factor I (IGF-I), growth hormone (GH), tumor necrosis factor-alpha (TNF) and interleukin-6 (IL6) in Alzheimer disease (AD) and mild cognitive impairment (MCI) patients. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004; pp. 36.

Álvarez, A., Laredo, M., Sampedro, C., Cacabelos, R. Vargas, M., Illescas, I. Prevalence of neuropsychiatric symptoms (NPS) in a clinical population of APOE-genotyped patients: Alzheimer disease (AD) versus mild cognitive impairment. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004; pp. 37.

Álvarez, A., Varela, M., Sampedro, C., Cruceiro, V., Cacabelos, R., Moessler, H. Positive effects of cerebrolysin in Alzheimer disease (AD): a randomized, double-blind, placebo-controlled trial (RCT). 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004; pp. 38.

Álvarez, A., Cacabelos, R., Moessler, H., Doppler, E. Cerebrolysin in moderate to moderately severe Alzheimer disease (AD): Subgroup analysis of a randomized, double-blind, placebo-controlled trial (RCT). 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004; pp. 39.

Fernández-Novoa, L., Lombardi, V., Seoane, S., Cacabelos, R. Alpha-2-macroglobulin polymorphisms in probable Alzheimer disease. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004; pp. 58.

Fernández-Novoa, L., Corzo, L., Zas, R., Seoane, S., Cacabelos, R. ACE InDel polymorphism, serum ACE activity and plasma beta-amyloid in dementia. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004; pp. 59.

Lombardi, V., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Cellular immune changes in peripheral blood of Alzheimer disease patients. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004; pp. 85.

Lombardi, V., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Activation of immune cells in peripheral blood of Alzheimer disease patients. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, April 14-17, 2004; pp. 86.

Cacabelos, R. The pathogenic role of histamine in Alzheimer disease. 33rd Annual Meeting European Histamine Research Society. Düsseldorf/Köln, April 28-May 2, 2004; pp. 30.

Álvarez, X.A., Cacabelos, R., Vargas, M., Aleixandre, M., Linares, C., Granizo, E., Moessler, H. Dose-response effects of cerebrolysin in Alzheimer’s disease patients: A randomized, double-blind, placebo-controlled trial. XXIV CINP Congress, June 2004. Int. J. Neuropsychopharmacol., 7(Suppl.1): S383 (2004).

Lombardi, V., Álvarez, X.A., Echeverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Alterations in percentages of lymphocyte subpopulations in peripheral blood of Alzheimer’s disease patients. XXIV CINP Congress, June 2004. Int. J. Neuropsychopharmacol., 7(Suppl.1 : S383 (2004).

Álvarez, X.A., Laredo, M., Cruceiro, V., Sampedro, C., Cacabelos, R., Illescas, E., Vargas, M., Moessler, H. Frequency and severity of neuropsychiatric symptoms in Alzheimer’s disease and mild cognitive impairment: influence of the APOE genotype. XXIV CINP Congress, June 2004. Int. J. Neuropsychopharmacol., 7(Suppl.1): S384 (2004).

Cacabelos, R. Genética y envejecimiento. Congreso Internacional. El Reto del Envejecimiento 1979-2004. 25 Años de Atención Gerontológico en México. México DF, 16-18 Junio, 2004.

Cacabelos, R. Farmacogenómica y envejecimiento. Galisenior. 4º Salón Gallego de Nuestros Mayores. I Foro Europeo sobre Envejecimiento. Orense, 21-23 Octubre, 2004.

2003

Cacabelos, R. Foro de nuevas bioempresas. EBIOTEC. BioSpain/Asebio-2003. Madrid, 23-28 Feb. (2003).

Cacabelos, R. Genetic variation and pharmacogenomic profiles in Alzheimer disease. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 3.

Álvarez, X.A., Sampedro, C., Cacabelos, R. Central amyloid-beta impairs learning and induces glial activation, neuronal loss and apoptosis in rats. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 16.

Álvarez, X.A., Sampedro, C., Cacabelos, R., Windisch, M. AF64A-induced neuronal apoptosis in the septohippocampal area. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 17.

Álvarez, X.A., Sampedro, C., Cacabelos, R., Sempere, J.M., Díaz, J. Anapsos reverses beta-amyloid-induced learning impairment, neuronal loss and apoptosis. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 17.

Amado, L., Etcheverría, I., Pichel, V., Moreno, A., Cacabelos, R. Age-dependent changes in brain atrophy parameters. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 17.

Amado, L., Etcheverría, I., Pichel, V., Moreno, A., Corzo, L., Zas, R., Lombardi, V., Cacabelos, R. Influence of vascular risk factors on brain atrophy. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 17.

Lombardi, V.R.M., Díaz, J., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Blanco, A., Cacabelos, R. Regulation of MHC class-I and class-II expression on primary microglial cells by natural compounds. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 28.

Pichel, V., Amado, L., Etcheverría, I., Cacabelos, R. Age-dependent cerebrovascular hemodynamic changes. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 33.

Pichel, V., Amado, L., Etcheverría, I., Corzo, L., Zas, R., Alcaraz, M., Mulet, E., Rodríguez, S., Cacabelos, R. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 33.

Pichel, V., Figueroa, J., Cornes, J.M., Álvarez, X.A., Etcheverría, I., Fernández-Novoa, L., Amado, L., Hernández, A., Varela, M., Cacabelos, R. Cervico-arthrosis is associated with occipital EEG slowing and a poor brain perfusion in women. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 34.

Aguilar-Aldrete, M.E., Cacabelos, R., Rosales-Gómez, R.C., Rodríguez-Vera, M.C., Silva-Lepe, Y., Moran-Moguel, M.C. The apolipoprotein E genotype in western Mexican population with Alzheimer disease. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 54.

Álvarez, X.A., Lombardi, V., Sampedro, C., Corzo, L., Zas, R., Pérez, P., Laredo, M., Cruceiro, V., Astoreka, I., Varela, M., Fernández-Novoa, L., Cacabelos, R., Stoeffler, A., Moebius, H.J. Genotype-related reduction of apoptosis in Alzheimer’s disease patients treated with memantine. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 54.

Isaza, C., Henao, J., Fernández-Novoa, L., Cacabelos, R. The drug metabolizer CYP2D6 gene in Alzheimer disease therapy. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 56.

Etcheverría, I., Pichel, V., Amado, L., Fernández-Novoa, L., Lombardi, V., Cacabelos, R. APOE genotype-related brain atrophy in the Spanish population. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 57.

Etcheverría, I., Pichel, V., Amado, L., Fernández-Novoa, L., Alcaraz, M., Mulet, E., Rodríguez, S., Cacabelos, R. APOE-related cerebrovascular hemodynamics in the Spanish population. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 57.

Fernández-Novoa, L., Lombardi, V.R.M., Corzo, L., Laredo, M., Cruceiro, V., Álvarez, X.A., Cacabelos, R. Association study between DCPI genotype and Alzheimer’s disease. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 58.

Kubota, Y., Pichel, V., Fernández-Novoa, L., Lombardi, V., Álvarez, A., Mollet, E., Alcaraz, M., Rodríguez, S., Laredo, M., Cruceiro, V., Amado, L., Etcheverría, I., Cacabelos, R. Combination therapy in Alzheimer disease: A pharmacogenomic study. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 64.

Laredo, M., Couceiro, V., Fraile, C., Álvarez, X.A., Sampedro, C., Cacabelos, R. Neuropsychological evaluation of mild degenerative dementia patients: improving the screening capacity of the MMSE. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 65.

Pichel, V., Etcheverría, I., Amado, L., Cacabelos, R. Effect of cerebrovascular risk factors on brain hemodynamics in dementia. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 73.

Lombardi, V.R.M., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Cacabelos, R. Regulating factors for pathological activation of microglia in Alzheimer’s disease. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 121.

Álvarez, X.A., Sampedro, C., Corzo, L., Zas, R., Pérez, P., Pichel, V., Laredo, M., Cruceiro, V., Hernández, A., Varela, M., Figueroa, J., Lombardi, V., Fernández-Novoa, L., Cacabelos, R., Moessler, H. Cerebrolysin improves cognition and brain bioelectrical activity in senile dementia and in traumatic brain injury patients. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 126.

Cacabelos, R., Kubota, Y., Pichel, V., Lombardi, V., Mollet, E., Alcaraz, M., Rodríguez, S., Amado, L., Corzo, L., Zas, R., Fernández-Novoa, L., Suárez, J., Pardo, R. E-SAR-94010: A novel pleiotropic compound with age-dependent regulatory activity on lipid metabolism. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 127.

Corzo, L., Zas, R., Fernández-Novoa, L., Cacabelos, R. FERUM nitric oxide study in Alzheimer disease. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 128.

Corzo, L., Zas, R., Fernández-Novoa, L., Álvarez, X.A., Laredo, M., Cruceiro, V., Sampedro, C., Rodríguez, S., Cacabelos, R. Study of serum apolipoprotein E in Alzheimer disease. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 128.

Fernández-Novoa, L., Corzo, L., Seoane, S., Zas, R., Sampedro, C., Álvarez, X.A., Lombardi, V.R.M., Cacabelos, R. ACE serum activity and I/D genetic polymorphism in elderly subjects. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 129.

Lombardi, V.R.M., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Cacabelos, R. Flow cytometry analysis of supressor cell precursor and memory T lymphocytes in the peripheral blood of Alzheimer’s disease patients. 6th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD-2003), Seville, May 8-12, 2003; pp. 131.

Takeda, M., Cacabelos, R. (Co-chairmen), Yamada, T., Maelick, A., Kurz, A. Roundtable Discussion Meeting on Treatment for Patients with Dementia. Salón Lebrija. Hotel Meliá Sevilla, May 12, 2003.

Álvarez, X.A., Sampedro, C., Laredo, M., Cruceiro, V., Fernández-Novoa, L., Kubota, Y., Cacabelos, R., Vargas, M. Differential influence of neuropsychiatric symptoms on functional and cognitive decline in mild-moderate Alzheimer’s disease. World Psychiatric Association. International Thematic Conference. Diagnosis in Psychiatry: Integrating the sciences. Vienna, 19-22 June, 2003; pp. 41.

Isaza, C., Henao, J., Fernández-Novoa, L., Kubota, Y., Cacabelos, R. The drug metabolizer CYP2D6 in Alzheimer’s disease. World Psychiatric Association. International Thematic Conference. Diagnosis in Psychiatry: Integrating the sciences. Vienna, 19-22 June, 2003; pp. 42.

Lombardi, V., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Kubota, Y., Cacabelos, R. Peripheral blood analysis of CD28-/CD8+ supressor cell precursor and CD45RO+/CD4+ memory T-lymphocytes in patients with Alzheimer’s disease. World Psychiatric Association. International Thematic Conference. Diagnosis in Psychiatry: Integrating the sciences. Vienna, 19-22 June, 2003; pp. 42.

Fernández-Novoa, L., Corzo, L., Seoane, S., Lombardi, V., Kubota, Y., Cacabelos, R. ACE serum activity and ACE genetic polymorphisms in elderly subjects. World Psychiatric Association. International Thematic Conference. Diagnosis in Psychiatry: Integrating the sciences. Vienna, 19-22 June, 2003; pp. 42.

Amado, L., Etcheverría, I., Pichel, V., Kubota, Y., Cacabelos, R. Age-dependent brain atrophy in CNS disorders: A CT-Scan study. World Psychiatric Association. International Thematic Conference. Diagnosis in Psychiatry: Integrating the sciences. Vienna, 19-22 June, 2003; pp. 42-43.

Etcheverría, I., Pichel, V., Amado, L., Fernández-Novoa, L., Kubota, Y., Cacabelos, R. Differential brain atrophy profile associated with APOE genotype in CNS disorders. World Psychiatric Association. International Thematic Conference. Diagnosis in Psychiatry: Integrating the sciences. Vienna, 19-22 June, 2003; pp. 43.

Pichel, V., Amado, L., Etcheverría, I., Fernández-Novoa, L., Kubota, Y., Cacabelos, R. APOE-related cerebrovascular risk factors and hemodynamics in CNS disorders. World Psychiatric Association. International Thematic Conference. Diagnosis in Psychiatry: Integrating the sciences. Vienna, 19-22 June, 2003; pp. 43.

Etcheverría, I., Amado, L., Pichel, V., Cacabelos, R. Age- and APOE-dependent cerebrovascular changes in the Spanish population. 6th International Conference on Stroke and 3rd Conference on the Mediterranean Stroke Society. Monte Carlo, March 12-15, 2003; pp. 32.

Pichel, V., Amado, L., Etcheverría, I., Cacabelos, R. Age-dependent changes in brain hemodynamic parameters. 6th International Conference on Stroke and 3rd Conference on the Mediterranean Stroke Society. Monte Carlo, March 12-15, 2003; pp. 38.

Etcheverría, I., Amado, L., Pichel, V., Cacabelos, R. Age-dependent brain atrophy: A CT-Scan study. 6th International Conference on Stroke and 3rd Conference on the Mediterranean Stroke Society. Monte Carlo, March 12-15, 2003; pp. 47.

Etcheverría, I., Amado, L., Pichel, V., Cacabelos, R. Differential brain atrophy profile associated with the APOE genotype in the Spanish population. 6th International Conference on Stroke and 3rd Conference on the Mediterranean Stroke Society. Monte Carlo, March 12-15, 2003; pp. 47.

Pichel, V., Amado, L., Etcheverría, I., Cacabelos, R. Vascular risk factors and brain atrophy: A correlation analysis in the Spanish population. 6th International Conference on Stroke and 3rd Conference on the Mediterranean Stroke Society. Monte Carlo, March 12-15, 2003; pp. 55.

Pichel, V., Amado, L., Etcheverría, I., Fernández-Novoa, L., Laredo, M., Cruceiro, V., Alcaraz, M., Rodríguez, S., Mulet, E., Cacabelos, R. APOE-related cerebrovascular risk factors and hemodynamics in dementia. 6th International Conference on Stroke and 3rd Conference on the Mediterranean Stroke Society. Monte Carlo, March 12-15, 2003; pp. 55.

Amado, L., Etcheverría, I., Pichel, V., Fernández-Novoa, L., Lombardi, V.R.M., Cacabelos, R. APOE genotype-related brain atrophy in the Spanish population. First Congress of the International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG 2003). Göteborg, 2003; pp. 33.

Etcheverría, I., Pichel, V., Amado, L., Fernández-Novoa, L., Alcaraz, M., Mulet, E., Rodríguez, S., Cacabelos, R. APOE-related cerebrovascular hemodynamics in the Spanish population. First Congress of the International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG 2003). Göteborg, 2003; pp. 55.

Cacabelos, R., Fernández-Novoa, L., Etcheverría, I., Tellado, I., Kubota, Y., Lombardi, V., Pichel, V.M. APOE-related phenotypic variation in brain bioelectrical activity mapping. First Congress of the International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG 2003). Göteborg, 2003; pp. 58-59.

Pichel, V., Amado, L., Etcheverría, I., Corzo, L., Zas, R., Alcaraz, M., Mulet, E., Rodríguez, S., Cacabelos, R. Vascular risk factor-associated brain hemodynamics. First Congress of the International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG 2003). Göteborg, 2003; pp. 60-61.

Cacabelos, R. Potential role of histamine and cytokine networks in Alzheimer disease and neurodegeneration. 1st International Symposium of Neurobehavioral Pharmacology. Okayama, September 13-15, 2003; pp. 72.

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Seoane, S., Cacabelos, R. Chronic activation of immune/inflammatory cells in Alzheimer’s disease. VI European Meeting on Glial Cell Function in Health and Disease. Berlin, September 3-6, 2003; P-104.

Álvarez, X.A., Laredo, M., Cruceiro, V., Fernández-Novoa, L., Sampedro, C., Cacabelos, R., Vargas, M., Aleixandre, M. Neuropsychiatric symptoms in APOE-genotyped Alzheimer’s disease patients: Contributions to diagnosis and prognosis of the disease. 16th Congress of the European College of Neuropsychopharmacology. Prague, September 20-24, 2003. European Neuropsychopharmacology, 13(Suppl.4):S399-S400 (2003).

Álvarez, X.A., Sampedro, C., Laredo, M., Cruceiro, V., Pérez, P., Cacabelos, R., Moessler, H., Doppler, E. Effects of cerebrolysin on quantitative EEG activity in elderly controls and in patients with brain damage. 16th Congress of the European College of Neuropsychopharmacology. Prague, September 20-24, 2003. European Neuropsychopharmacology, 13(Suppl.4):S400 (2003).

Álvarez, X.A., Sampedro, C., Cacabelos, R. Memory deficits and neuropathology induced by central amyloid-beta injections in rats. 16th Congress of the European College of Neuropsychopharmacology. Prague, September 20-24, 2003. European Neuropsychopharmacology, 13(Suppl.4):S405 (2003).

Álvarez, X.A., Lombardi, V., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Cacabelos, R. CD28-/CD8+ supressor cell precursor and CD45RO+/CD4+ memory T lymphocyte expressions in the peripheral blood of Alzheimer’s disease patients. 16th Congress of the European College of Neuropsychopharmacology. Prague, September 20-24, 2003. European Neuropsychopharmacology, 13(Suppl.4):S406 (2003).

Pichel, V., Etcheverría, I., Amado, L., Kubota, Y., Cacabelos, R. Phenotypic profiles of vascular dementia and Alzheimer disease associated with brain atrophy and cerebrovascular hemodynamics. 3rd International Congress on Vascular Dementia. Prague, October 23-26, 2003; pp. 38.

Corzo, L., Zas, R., Fernández-Novoa, L., Cacabelos, R. Oxidative and vascular blood markers in dementia. 3rd International Congress on Vascular Dementia. Prague, October 23-26, 2003; pp. 43.

Etcheverría, I., Pichel, V., Amado, L., Moreno, A., Cacabelos, R. Brain atrophy-associated vascular risk factors. 3rd International Congress on Vascular Dementia. Prague, October 23-26, 2003; pp. 47.

Etcheverría, I., Pichel, V., Fernández-Novoa, L., Cacabelos, R. Association between different APOE genotypes and cerebrovascular parameters assessed by transcranial Doppler ultrasonography in the Spanish population. 3rd International Congress on Vascular Dementia. Prague, October 23-26, 2003; pp. 47.

Pichel, V., Etcheverría, I., Corzo, L., Zas, R., Cacabelos, R. Effects of vascular risk factors on brain hemodynamic parameters. 3rd International Congress on Vascular Dementia. Prague, October 23-26, 2003; pp. 51.

Pichel, V., Etcheverría, I., Cacabelos, R. Age-related cerebrovascular changes in hemodynamic parameters. 3rd International Congress on Vascular Dementia. Prague, October 23-26, 2003; pp. 51.

Etcheverría, I., Vallejo, A.I., Lombardi, V.R.M., Corzo, L., Zas, R., Cacabelos, R. Efecto de BioKin sobre parámetros bioquímicos en sangre de ratas con suplementación dietética. IX Congreso de la Sociedad Española de Nutrición. Tenerife, Noviembre 26-29, 2003. Nutrición Hospitalaria, XVIII/5:296 (2003).

Vallejo, A.I., Etcheverría, I., Lombardi, V.R.M., Cacabelos, R. Efecto de BioKin sobre el crecimiento en ratas. IX Congreso de la Sociedad Española de Nutrición. Tenerife, Noviembre 26-29, 2003. Nutrición Hospitalaria, XVIII/5:297 (2003).

Vallejo, A.I., Lombardi, V., Fernández-Novoa, L., Pichel, V., Amado, L., Cacabelos, R. E-SAR-94010 (LipoEsar): Un compuesto lipoproteico pleiotrópico con un poderoso efecto anti-ateromatoso e hipolipemiante. IX Congreso de la Sociedad Española de Nutrición. Tenerife, Noviembre 26-29, 2003. Nutrición Hospitalaria, XVIII/5:318 (2003).

Etcheverría, I., Vallejo, A.I., Lombardi, V., Corzo, L., Zas, R., Cacabelos, R. BioKin effects on the blood biochemical parameters of rats with a supplemented diet. Nutrition, 19:1052-1053 (2003).

Vallejo, A.I., Lombardi, V., Fernández-Novoa, L., Pichel, V., Amado, L., Cacabelos, R. E-SAR-94010 (LipoEsar): A pleiotropic lipoprotein compound with powerful anti-atheromatous and lipid-lowering effects. Nutrition, 19:1066 (2003).

2002

Cacabelos, R. Family, work and health. First CEDE International Congress of Directors. Enterpreneurs with values: Directors and the new Europe-America partnership. Madrid Nov. 29-30 (2002).

Cacabelos, R. Genomics: Implications for diagnosis and treatment. Aging at XXI century. Thinking the future. Coimbra University Hospitals, Coimbra, 21-23 March, 2002.

Cacabelos, R. Workshop “Mild Cognitive Impairment: Concept and Realities”. Divonne-les-Bains, France, April 1-2, 2002.

Cacabelos, R. Pharmacogenomics and treatment of Alzheimer disease. 7th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 3-6, pp. 39, 2002.

Álvarez, X.A., Sampedro, C., Sempere, J.M., Díaz, J., Cacabelos, R. Antiapoptotic and neuroprotective effects of anapsos in rats with beta-amyloid injections into the hippocampus. 7th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 3-6, pp. 161, 2002.

Álvarez, X.A., Sampedro, C., Pérez, P., Pichel, V., Hernández, A., Varela, M., Figueroa, J., Laredo, M., Couceiro, V., Corzo, L., Moessler, H., Cacabelos, R. Positive effects of cerebrolysin on brain bioelectrical activity and cognitive performance in traumatic brain injury and in senile dementia patients. 7th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 3-6, pp. 162, 2002.

Fernández-Novoa, L., Lombardi, V.R.M., Fondevila, M., Seoane, S., Cacabelos, R. Prion protein gene (PRNP) polymorphisms in Alzheimer disease. 7th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 3-6, pp. 183, 2002.

Lombardi, V.R.M., Fernández-Novoa, L., Etcheverría, I., Cacabelos, R. Cytokine production by human peripheral blood mononuclear cells in Alzheimer disease. 7th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 3-6, pp. 212, 2002.

Pichel, V., Pérez, P., Fernández-Novoa, L., Laredo, M., Couceiro, V., Alcaraz, M., Rodríguez, S., Mulet, E., Cacabelos, R. Cerebrovascular risk factors and hemodynamics in dementia. 7th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 3-6, pp. 228, 2002.

Cacabelos, R., Fernández-Novoa, L., Lombardi, P., Laredo, M., Couceiro, V., Pichel, V., Álvarez, A. Alzheimer Disease-Associated Genes: Genomic Screening in the Spanish Population. Proceedings ELSO 2002, Nice, France, June 29-July 3, pp. 20 (2002).

Lombardi, V., Fernández-Novoa, L., Cacabelos, R. Evaluation of TNF-alpha and IL-10 levels in peripheral blood mononuclear cells of Alzheimer patients measured by a cytometric bead array system. Proceedings ELSO 2002, Nice, France, June 29-July 3, pp. 281 (2002).

Fernández-Novoa, L., Lombardi, V., Cacabelos, R. Association studies of polymorphisms in the angiotensin converting enzyme gene (ACE) and Alzheimer’s disease (AD) in the Spanish population. Proceedings ELSO 2002, Nice, France, June 29-July 3, pp. 294 (2002).

Álvarez, A., Sampedro, C., Fernández-Novoa, L., Lombardi, V., Cacabelos, R. Amyloid beta-induced neurodegeneration in vivo: An experimental model to test potential anti-dementia drugs. Proceedings ELSO 2002, Nice, France, June 29-July 3, pp. 308 (2002).

Álvarez, A., Cacabelos, R., Fernández-Novoa, L., Lombardi, V. Pharmacogenomics and treatment of Alzheimer’s disease. XXIIIrd CINP Congress, June 23-27, Montréal, Canada, P.1.W.071. Intern. J. Neuropsychopharmacol., 5(Suppl.1):S90 (2002).

Álvarez, A., Fernández-Novoa, L., Lombardi, V.R.M., Fondevila, M., Seoane, S., Cacabelos, R. M129V polymorphism at the PRNP gene and Alzheimer’s disease in the Spanish population. XXIIIrd CINP Congress, June 23-27, Montréal, Canada, P.2.E.098. Intern. J. Neuropsychopharmacol., 5(Suppl.1):S118 (2002).

Álvarez, A., Cacabelos, R., Fernández-Novoa, L., Lombardi, V., Pérez, P., Laredo, M., Couceiro, V., Alcaraz, M., Rodríguez, S., Sampedro, C., Pichel, V. Genomic screening of Alzheimer’s disease-associated genes in the Spanish population. XXIIIrd CINP Congress, June 23-27, Montréal, Canada, P.2.E.095. Intern. J. Neuropsychopharmacol., 5(Suppl.1):S117 (2002).

Álvarez, A., Cacabelos, R., Pichel, V., Pérez, P., Fernández-Novoa, L., Laredo, M., Couceiro, V., Alcaraz, M., Rodríguez, S., Mulet, E., Sampedro, C., Lombardi, V. Cerebrovascular risk factors and hemodynamics in dementia. XXIIIrd CINP Congress, June 23-27, Montréal, Canada, P.1.W.067. Intern. J. Neuropsychopharmacol., 5(Suppl.1):S89 (2002).

Álvarez, A., Sampedro, C., Pérez, P., Pichel, V., Hernández, A., Varela, M., Figueroa, J., Laredo, M., Couceiro, V., Corzo, L., Moessler, H., Cacabelos, R. Cerebrolysin improves brain bioelectrical activity pattern and cognitive functioning in traumatic brain injury and in senile dementia. XXIIIrd CINP Congress, June 23-27, Montreal, Canada, P.1.W.081. Intern. J. Neuropsychopharmacol., 5(Suppl.1):S92 (2002).

Álvarez, A., Sampedro, C., Sempere, J.M., Díaz, J., Cacabelos, R. Central beta-amyloid impairs learning and induces neuronal degeneration and apoptosis in rats: Neuroprotective effects of Anapsos. XXIIIrd CINP Congress, June 23-27, Montreal, Canada, P.3.W.084. Intern. J. Neuropsychopharmacol., 5(Suppl.1):S177 (2002).

Cacabelos, R. Avances en biología molecular, genética y neuroquímica de la esquizofrenia. II International Congress ARAPDIS & IX Congress Mediterranean Social Psychiatrie (MESPA), Barcelona, May 26-30 (2002).

Cacabelos, R., Artigas, F., Fañanas, L., Bulbena, A., Taboada, A. Bases etiopatogénicas de la esquizofrenia: Genética, biología molecular, neuroquímica y neurofarmacología. II International Congress ARAPDIS & IX Congress Mediterranean Social Psychiatrie (MESPA), Barcelona, May 26-30 (2002).

Álvarez, A., Sampedro, C., Sempere, J.M., Díaz, J., Cacabelos, R. Anapsos reverses the neurotoxic effects of central beta-amyloid injections in rats: Behavioral and morphological evaluations. The 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden, July 20-25, 2002. Neurobiol. Aging, 23(Suppl.1):S97 (2002).

Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R., Quack, G. Memantine prevents beta-amyloid-induced neurotoxicity and learning impairment in rats. The 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden, July 20-25, 2002. Neurobiol. Aging, 23(Suppl.1):S102 (2002).

Cacabelos, R., Álvarez, A., Pérez, P., Laredo, M., Couceiro, V., Alcaraz, M., Rodríguez, S., Pichel, V. Multifactorial therapy in vascular dementia and Alzheimer disease. The 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden, July 20-25, 2002. Neurobiol. Aging, 23(Suppl.1):S121 (2002).

Lombardi, V., Fernández-Novoa, L., Cacabelos, R. Increased TNF-alpha and IL-10 production by human peripheral blood mononuclear cells in Alzheimer’s disease measured by a cytometric bead array system. The 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden, July 20-25, 2002. Neurobiol. Aging, 23(Suppl.1):S229 (2002).

Cacabelos, R., Fernández-Novoa, L., Lombardi, V., Pérez, P., Laredo, M., Couceiro, V., Alcaraz, M., Rodríguez, S., Pichel, V., Álvarez, A. Genomic screening of Alzheimer’s disease-associated genes in the Spanish population. The 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden, July 20-25, 2002. Neurobiol. Aging, 23(Suppl.1):S318 (2002).

Fernández-Novoa, L., Lombardi, V., Seoane, S., Cacabelos, R. M129V polymorphism at the PRNP gene in Alzheimer’s disease. The 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden, July 20-25, 2002. Neurobiol. Aging, 23(Suppl.1):S320 (2002).

Fernández-Novoa, L., Lombardi, V., Seoane, S., Cacabelos, R. Angiotensin converting enzyme gene polymorphism (ACE) and Alzheimer’s disease (AD) in the Spanish population. The 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden, July 20-25, 2002. Neurobiol. Aging, 23(Suppl.1):S346 (2002).

Cacabelos, R., Fernández-Novoa, L., Lombardi, V., Takeda, M. Genomic variation and pharmacogenomic studies in Alzheimer disease. XII World Congress of Psychiatry. Yokohama, August 24-29, pp. 111 (2002).

Takeda, M., Cacabelos, R., Ray, O., Forstl, H., Hoon Oh, B. International situation of diagnosing dementia and the direction of future study. Cognition and Dementia. Round Table Discussion. Yokohama, August 27 (2002).

Cacabelos, R. Genomic screening, genetic variation and pharmacogenomics in Alzheimer disease. International Symposium “Molecular Neurobiology of Alzheimer Disease and Related Disorders”. Osaka Sun Palace Hotel, Osaka, October 5; Dementia Japan 16:83 (2002).

Fernández-Novoa, L., Lombardi, V., Seoane, S., Cacabelos, R. Distribution of APOE genotypes in CNS disorders in the Spanish population. Am. J. Med. Genet., 114/7:789 (2002).

Cacabelos, R., Lombardi, V., Fernández-Novoa, L. Genomic variation in Alzheimer disease. Am. J. Med. Genet., 114/7:829 (2002).

Fernández-Novoa, L., Lombardi, V.R.M., Fondevila, M., Seoane, S., Cacabelos, R. Association study of M129V polymorphism at the PRNP gene in Alzheimer disease. Am. J. Med. Genet., 114/7:829-830 (2002).

Álvarez, A., Sampedro, C., Cacabelos, R. Effects of central beta-amyloid on learning, glial activation, neuronal degeneration and apoptosis in rats. 6th Congress of the European Federation of Neurological Societies. Vienna, October 26-29, 2002. Eur. J. Neurol., 9(Suppl.2):158-159 (2002).

Álvarez, A., Sampedro, C., Corzo, L., Pérez, P., Pichel, V., Laredo, M., Hernández, A., Varela, M., Figueroa, J., Cacabelos, R., Windisch, M., Moessler, H. . 6th Congress of the European Federation of Neurological Societies. Vienna, October 26-29, 2002. Eur. J. Neurol., 9(Suppl.2):198 (2002).

2001

Cacabelos, R., Fernández-Novoa, L., Álvarez, X.A., Lombardi, V. Distribution of polygenic genotypes in Alzheimer disease (AD): Genomic screening of AD-associated genes. Eur. Neuropsychopharmacol., 11(Suppl.1):S15 (2001).

Cacabelos, R., Fernández-Novoa, L., Álvarez, X.A., Lombardi, V. Pharmacogenomic studies in Alzheimer disease with a multifactorial treatment. Eur. Neuropsychopharmacol., 11(Suppl.1):S15 (2001).

Fernández-Novoa, L., Lombardi, V., Pérez-Herrera, S., Cacabelos, R. Angiotensin-converting enzyme I/D polymorphism in polygenic disorders. Eur. Neuropsychopharmacol., 11(Suppl.1):S16 (2001).

Izasa, C., Henao, J., López, A.M., Cacabelos, R. CYP2D6 allelic variants in the Colombian population. Eur. Neuropsychopharmacol., 11(Suppl.1):S16 (2001).

Cacabelos, R. Innovación biotecnolóxica e iniciativa empresarial. GALIEMPREGO 2001. III Feira da Formación e o Emprego. Xunta de Galicia, Santiago de Compostela, 15-17 Mayo, 2001.

Cacabelos, R. Immune function, cytokines and apoptosis in Alzheimer disease: Implications for drug monitoring and pharmacogenomics. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; A-5-4, pp. 13 (2001).

Fernández-Novoa, L., Lombardi, V., Álvarez, X.A., Corzo, L., Pérez-Herrera, S., Sampedro, C., Zas, R., Cacabelos, R. Alpha 2-macroglobulin polymorphisms in early- and late-onset Alzheimer’s disease. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; III-AD-15, pp. 39 (2001).

Fernández-Novoa, L., Lombardi, V., Álvarez, X.A., Corzo, L., Pérez-Herrera, S., Sampedro, C., Zas, C., Cacabelos, R. Angiotensin-converting enzyme I/D polymorphism in multifactorial human diseases. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; III-AD-16, pp. 39 (2001).

Laredo, M., Couceiro, V., Pérez, P., Álvarez, X.A., Cacabelos, R. Senile Dementia-Associated Sleep Disorders Scale (SDASDS). New data on the validation of the Sleep-Related Subscale. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; III-AD-31, pp. 43 (2001).

Pérez, P., Laredo, M., Álvarez, X.A., Cacabelos, R. Fronto-temporal brain bioelectrical activity theta correlates with hallucinations in Alzheimer disease. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; III-AD-32, pp. 43 (2001).

Álvarez, X.A., Sampedro, C., Lozano, R., Secades, J., Cacabelos, R. Citicoline reduces neuronal degeneration and apoptosis induced by -amyloid and hypoperfusion in rats. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; III-AD-51, pp. 48 (2001).

Álvarez, X.A., Sampedro, C., Lombardi, V., Fernández-Novoa, L., Cacabelos, R., Moessler, H., Windisch, M. Procognitive, immunomodulatory and neurotrophic activities of Cerebrolysin in an animal model of hippocampal degeneration. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; III-AD-55, pp. 49 (2001).

Corzo, L., Zas, R., Fernández-Novoa, L., Álvarez, X.A., Lombardi, V., Cacabelos, R. Vitamin B12 and folate deficiency in dementia. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; V-AD-06, pp. 93 (2001).

Corzo, L., Zas, R., Fernández-Novoa, L., Álvarez, X.A., Lombardi, V., Cacabelos, R. Thyroid function study in dementia. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; V-AD-07, pp. 93 (2001).

Álvarez, X.A., Pichel, V., Pérez, P., Laredo, M., Fernández-Novoa, L., Corzo, L., Zas, R., Alcaraz, M., Sampedro, C., Cacabelos, R., Secades, J., Lozano, R. Citicoline improves cognitive performance, brain bioelectrical activity and cerebral perfusion in APOE-genotyped Alzheimer disease patients. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; V-AD-26, pp. 98 (2001).

Álvarez, X.A., Lombardi, V., Corzo, L., Pérez, P., Pichel, V., Laredo, M., Hernández, A., Freixeiro, F., Varela, M., Sampedro, C., Alcaraz, M., Rodríguez, S., Cacabelos, R., Windisch, M., Moessler, H. Oral Cerebrolysin in elderly humans: Effects on memory and brain bioelctrical activity. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; V-AD-27, pp. 98 (2001).

Álvarez, X.A., Pichel, V., Pérez, P., Laredo, M., Corzo, D., Sampedro, C., Zas, R., Fernández-Novoa, L., Cacabelos, R., Sempere, J.M., Díaz, J. Procognitive and neurobiological effects of anapsos in senile dementia: A double-blind and placebo-controlled study. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; V-AD-28, pp. 98 (2001).

Lombardi, V.R.M., Fernández-Novoa, L., Álvarez, X.A., Corzo, L., Zas, R., Cacabelos, R. Peripheral immune dysfunction in Alzheimer disease. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; V-AD-37, pp. 100 (2001).

Cacabelos, R., Fernández-Novoa, L., Álvarez, X.A., Corzo, L., Laredo, M., Pérez, P., Pichel, V., Lombardi, V. Multifactorial treatment and pharmacogenomics in Alzheimer disease. The 5th International Conference on Progress in Alzheimer’s and Parkinson’s disease. Kyoto, March 31-April 5, 2001; V-AD-46, pp. 103 (2001).

Cacabelos, R. Psychogeriatric research: Strategies and development. 16th Jap. Congr. Psychogeriatrics. Osaka, 13-15 June, 2001.

Cacabelos, R. Prospective treatments in Alzheimer disease. 16th Jap. Congr. Psychogeriatrics. Osaka, 13-15 June, 2001.

2000

Cacabelos, R. Os inhibidores da acetilcolinesterasa como factor de esperança no tratamento da doença de Alzheimer. O Idoso no Ano 2000. Velhos sao os Trapos. Auditorio dos Hospitais da Universidade de Coimbra. Associaçao Portuguesa de Gerontopsiquiatría. Coimbra, 20-22 Janeiro (2000).

Cacabelos, R. Genetica da doença de Alzheimer. Workshop Universidade de Coimbra. 22 Janeiro (2000).

Cacabelos, R. Avances en la etiología de las demencias. VII Congreso Nacional. Asociación Colombiana de Psiquiatría Biológica. Pereira, Colombia, 18-19 Marzo (2000).

Cacabelos, R. Farmacogenética de las demencias. VII Congreso Nacional. Asociación Colombiana de Psiquiatría Biológica. Pereira, Colombia, 18-19 Marzo (2000).

Cacabelos, R., Fernández-Novoa, L., Lombardi, V., Álvarez, X.A. Genotype-specific apoptosis and therapeutic response in Alzheimer disease: Implications for drug design and clinical trials. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 41 (2000).

Álvarez, X.A., Fernández-Novoa, L., De Olano, M., Sampedro, C., Lombardi, V., Windisch, M., Cacabelos, R. Cerebrolysin exerts neuroimmunotrophic and neuroprotective effects in an animal model of hippocampal neurodegeneration. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 197 (2000).

Álvarez, X.A., Lombardi, V.R.M., Corzo, L., Pérez, P., Pichel, V., Laredo, M., Hernández, A., Freixeiro, F., Sampedro, C., Lorenzo, R., Alcaraz, M., Windisch, M., Cacabelos, R. Oral Cerebrolysin potentiates brain alpha activity and improves memory in elderly humans. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 197 (2000).

Álvarez, X.A., Sampedro, C., Lozano, R., Secades, J., Cacabelos, R. Citicoline protects hippocampal neurons against apoptosis induced by brain -amyloid deposits plus cerebral hypoperfusion in rats. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 198 (2000).

Álvarez, X.A., Pichel, V., Pérez, P., Laredo, M., Corzo, L., Zas, R., Fernández-Novoa, L., Sempere, J.M., Díaz, J., Cacabelos, R. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: Effects on cognition, brain electrical activity and cerebral hemodynamics. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 198 (2000).

Cacabelos, R., Álvarez, X.A., Laredo, M., Couceiro, V., Anido, R., Pérez, P., Pichel, V., Corzo, L., Zas, R., Alcaraz, M., García, M., Rodríguez, S., Freixeiro, F., Figueroa, J., Hernández, M.A., Lombardi, V., Fernández-Novoa, L. Cognitive performance in dementia patients during a 4-year follow-up with a neuroprotective multifactorial treatment: Comparative effects for prevention in subjects at risk. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 201 (2000).

Cacabelos, R., Moreno, A., Caamaño, J.M., López, S., Pérez, P., Pichel, V., Laredo, M., Couceiro, V., Anido, R., Corzo, L., Zas, R., Alcaraz, M., Rodríguez, S., Hernández, M.A., Álvarez, X.A., Lombardi, V., Fernández-Novoa, L. Cognitive function and brain atrophy in dementia: A psychomorphometric correlation analysis. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 202 (2000).

de Olano, M., Fernández-Novoa, L., Mesa, M.D., Corzo, L., Cacabelos, R. Different allele frequency distribution in angiotensin-converting enzyme I/D polymorphism and angiotensinogen M235T polymorphism in dementia. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 205 (2000).

Fernández-Novoa, L., De Olano, M., Mesa, M.D., Cacabelos, R. Alpha-2 macroglobulin V1000I and insertion-deletion polymorphisms in Alzheimer’s disease. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 208 (2000).

Fernández-Novoa, L., de Olano, M., Mesa, M.D., Corzo, L., Lombardi, V., Álvarez, X.A., Cacabelos, R. Identification of two novel mutations in the amyloid precursor protein (APP) gene. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 208 (2000).

Lombardi, V.R.M., Fernández-Novoa, L., Sampedro, C., De Olano, M., Álvarez, X.A., Cacabelos, R. Overexpression of FAS/CD95 in spontaneous and induced apoptosis in lymphocytes from Alzheimer’s disease patients. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, April 5-8, pp. 217 (2000).

Cacabelos, R. Review of research in geriatric psychiatry. American Society of Hispanic Psychiatry and University of Chicago of Illinois at Chicago. Hispanic American Day at the APA Annual Meeting. May 13 (2000).

Álvarez, X.A., Lombardi, V.R.M., Fernández-Novoa, L., García, M., Sampedro, C., Cagiao, A., Windisch, M., Moessler, H., Cacabelos, R. Cerebrolysin reduces microglia activation in vivo and in vitro: A potential neuroprotection mechanism. Neuroinflammation in Alzheimer’s Disease. A Neurobiology of Aging Conference. Washington DC, 7-8 July, pp. 2.06 (2000).

Lombardi, V.R.M., Álvarez, X.A., Fernández-Novoa, L., García, M., Sampedro, C., de Olano, M., Cacabelos, R. Regulation of brain immunity: A central role played by -amyloid and IL-1 in microglial cells. Neuroinflammation in Alzheimer’s Disease. A Neurobiology of Aging Conference. Washington DC, 7-8 July, pp. 2.07 (2000).

Lombardi, V.R.M., Álvarez, X.A., Fernández-Novoa, L., de Olano, M., Corzo, L., Sampedro, C., Cacabelos, R. One year “plateau-phase” in microglial cell cultures. Neuroinflammation in Alzheimer’s Disease. A Neurobiology of Aging Conference. Washington DC, 7-8 July, pp. 2.08 (2000).

Cacabelos, R., Sampedro, C., Álvarez, X.A. Citicoline exerts antiapoptotic effects in an animal model of hippocampal neurodegeneration. World Alzheimer Congress 2000. Washington DC, July 9-13, pp. S87 (2000).

Lombardi, V., Cacabelos, R., Pérez, P., Laredo, M., Moessler, H., Hernández, A., Windisch, M., Álvarez, X.A. Cerebrolysin improves memory performance and the brain bioelectrical activity pattern in elderly humans. World Alzheimer Congress 2000. Washington DC, July 9-13, pp. S157 (2000).

Álvarez, X.A., Pichel, V., Pérez, P., Laredo, M., Corzo, L., Zas, R., Fernández-Novoa, L., Cacabelos, R. Dose-dependent effects of Anapsos in senile dementia patients: A double-blind, randomized, placebo-controlled study. World Alzheimer Congress 2000. Washington DC, July 9-13, pp. S218 (2000).

Mesa, M.D., Fernández-Novoa, L., de Olano, M., Cacabelos, R. Allele frequency of alpha-2 macroglobulin V1000I and insertion-deletion polymorphism in Alzheimer’s disease patients. World Alzheimer Congress 2000. Washington DC, July 9-13, pp. S250 (2000).

Fernández-Novoa, L., Mesa, M.D., Corzo, L., de Olano, M., Cacabelos, R. Two novel mutations in the amyloid precursor protein (APP) gene. World Alzheimer Congress 2000. Washington DC, July 9-13, pp. S250 (2000).

De Olano, M., Fernández-Novoa, L., Mesa, M.D., Corzo, L., Cacabelos, R. Angiotensin-converting enzyme I/D polymorphism and ansiotensinogen M235T polymorphism in dementia: A genetic study. World Alzheimer Congress 2000. Washington DC, July 9-13, pp. S250 (2000).

Lombardi, V.R.M., Álvarez, X.A., Fernández-Novoa, L., de Olano, M., Perea, L., Daniele, D., Cacabelos, R. Regulation of MHC class-I and class-II expression and neuronal death by citicoline. IV European Meeting on Glial Cell Function in Health and Disease. Barcelona, 24-27 May, pp. 100 (2000).

Lombardi, V.R.M., Álvarez, X.A., Sampedro, C., Miguel-Hidalgo, J.J., Quack, G., Cacabelos, R. Modulation of A(1-40)-induced neurodegeneration in the CA1 subfield by memantine. IV European Meeting on Glial Cell Function in Health and Disease. Barcelona, 24-27 May, pp. 100 (2000).

Lombardi, V.R.M., Álvarez, X.A., Sampedro, C., Cacabelos, R. Cerebrolysin-regulated microglial function through the modulation of proinflammatory cytokines. IV European Meeting on Glial Cell Function in Health and Disease. Barcelona, 24-27 May, pp. 107 (2000).

Álvarez, X.A., de Olano, M., Sampedro, C., Lombardi, V., Moessler, H., Windisch, M., Cacabelos, R. Cerebrolysin protects against neurodegeneration induced by -amyloid in rats. XXIInd CINP Congress, Brussels, 9-13 July, pp. S359 (2000).

Álvarez, X.A., Lombardi, V.R.M., Corzo, L., Zas, R., Pérez, P., Pichel, V., Laredo, M., Hernández, A., Freixeiro, F., Sampedro, C., Lorenzo, R., Alcaraz, M., Moessler, H., Windisch, M., Cacabelos, R. Oral Cerebrolysin accelerates the brain bioelectrical activity pattern and enhances memory performance in elderly humans. XXIInd CINP Congress, Brussels, 9-13 July, pp. S359 (2000).

Álvarez, X.A., Sampedro, C., Lozano, R., Secades, J., Cacabelos, R. Citicoline protects neurons against apoptosis induced by deposits of -amyloid into the hippocampus plus cerebral hypoperfusion in rats. XXIInd CINP Congress, Brussels, 9-13 July, pp. S359 (2000).

Cacabelos, R., Álvarez, X.A., Fernández-Novoa, L., Mesa, M., Olano, M., Laredo, M., Pichel, V., Pérez, P., Corzo, L., Lombardi, V. Genotype-related therapeutic response in Alzheimer’s disease: A pharmacogenomic approach. VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR-Division of Clinical Pharmacology & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT). Florence, 15-20 July, 2000. British J. Clin. Pharmacol., pp. 31 (2000).

Álvarez, X.A., Lombardi, V.R.M., Fernández-Novoa, L., García, M., Sampedro, C., Cagiao, A., Windisch, M., Moessler, H., Cacabelos, R. Cerebrolysin reduces microglia activation in vivo and in vitro. VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR-Division of Clinical Pharmacology & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT). Florence, 15-20 July, 2000. British J. Clin. Pharmacol., pp. 177 (2000).

Álvarez, X.A., Lombardi, V., Corzo, L., Pérez, P., Pichel, V., Laredo, M., Hernández, A., Freixeiro, F., Sampedro, C., Lorenzo, R., Alcaraz, M., Windisch, M., Moessler, H., Cacabelos, R. Cerebrolysin improves memory and induces brain bioelectrical activation in elderly humans after a single oral administration. VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR-Division of Clinical Pharmacology & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT). Florence, 15-20 July, 2000. British J. Clin. Pharmacol., pp. 177 (2000).

Álvarez, X.A., Pichel, V., Pérez, P., Laredo, M., Corzo, D., Zas, R., Fernández-Novoa, L., Sempere, J.M., Díaz, J., Cacabelos, R. Effects of anapsos on cognition, brain bioelectrical activity and cerebral hemodynamics in senile dementia: A double-blind, randomized, placebo-controlled study. VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR-Division of Clinical Pharmacology & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT). Florence, 15-20 July, 2000. British J. Clin. Pharmacol., pp. 125 (2000).

Álvarez, X.A., Mouzo, R., Pichel, V., Pérez, P., Laredo, M., Fernández-Novoa, L., Corzo, L., Zas, R., Alcaraz, M., Secades, J.J., Lozano, R., Cacabelos, R. Effects of citicoline on cognitive performance, brain bioelectrical activity and cerebral perfusion in APOE-genotyped Alzheimer’s disease patients. VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR-Division of Clinical Pharmacology & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT). Florence, 15-20 July, 2000. British J. Clin. Pharmacol., pp. 176 (2000).

Álvarez, X.A., Sampedro, C., Lozano, R., Secades, J., Cacabelos, R. Neuroprotective and antiapoptotic effects of citicoline in rats with hippocampal degeneration induced by -amyloid and hypoperfusion. VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR-Division of Clinical Pharmacology & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT). Florence, 15-20 July, 2000. British J. Clin. Pharmacol., pp. 176 (2000).

Álvarez, X.A., Miguel-Hidalgo, J.J., Quack, G., Cacabelos, R. Memantine protects against neuronal degeneration induced by A(1-40) in the CA1 subfield of the rat hippocampus. VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR-Division of Clinical Pharmacology & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT). Florence, 15-20 July, 2000. British J. Clin. Pharmacol., pp. 176 (2000).

Fernández-Novoa, L., de Olano, M., Mesa, M.D., Cacabelos, R. Alpha-2 macroglobulin polymorphism in Alzheimer’s disease. Eighth World Congress of Psychiatric Genetics. Versailles, 27-31 August, pp. 522 (2000).

de Olano, M., Fernández-Novoa, L., Mesa, M.D., Corzo, L., Cacabelos, R. Association between ACE I/D and APOE polymorphisms in different kinds of dementia. Eighth World Congress of Psychiatric Genetics. Versailles, 27-31 August, pp. 522 (2000).

Fernández-Novoa, L., de Olano, M., Mesa, M.D., Corzo, L., Cacabelos, R. Identification of two novel mutations in the amyloid precursor protein (APP) gene. Eighth World Congress of Psychiatric Genetics. Versailles, 27-31 August, pp. 522 (2000).

Cacabelos, R., Álvarez, X.A., Fernández-Novoa, L., Mesa, M.D., Olano, M., Laredo, M., Pichel, V., Pérez, P., Corzo, L., Lombardi, V. A pharmacogenomic approach to Alzheimer disease treatment. Eighth World Congress of Psychiatric Genetics. Versailles, 27-31 August, pp. 541 (2000).

Cacabelos, R. Hipertensión y demencia. VII Congreso de la Sociedad Gallega de Hipertensión Arterial. Sada, La Coruña, Sept. 8-9 (2000).

Corzo, L., Álvarez, X.A., Zas, R., Rodríguez, S., Pérez, P., Cacabelos, R. Niveles de tensión arterial, lípidos y glucosa en pacientes con demencia senil: Estudio de correlación. VII Congreso de la Sociedad Gallega de Hipertensión Arterial. Sada, La Coruña, Sept. 8-9, pp. 596 (2000).

Álvarez, X.A., Mouzo, R., Pichel, V., Laredo, M., Pérez, P., Couceiro, V., Corzo, L., Zas, R., Varela, M., Sampedro, C., Fernández-Novoa, L., Mesa, M.D., De Olano, M., Cacabelos, R. Tensión arterial y genotipo apolipoproteína E (APOE) en la demencia senil. VII Congreso de la Sociedad Gallega de Hipertensión Arterial. Sada, La Coruña, Sept. 8-9, pp. 600 (2000).

Fernández-Novoa, L., Corzo, L., de Olano, M., Cacabelos, R. Estudio de los polimorfismos de los genes ECA y AGT en demencia e hipertensión arterial. VII Congreso de la Sociedad Gallega de Hipertensión Arterial. Sada, La Coruña, Sept. 8-9, pp. 600 (2000).

Cacabelos, R. Update in Alzheimer therapeutics. Simposio Pfizer CNS. Demencia hoje… o olhar no futuro. Funchal, Madeira, Portugal. 23 Sept. (2000).

Cacabelos, R. Genética de la esquizofrenia y síndrome psicótico. XVIII Congreso Venezolano de Psiquiatría “Dr. Mauro Villegas”. Psiquiatría del Nuevo Milenio. Hotel Radisson Plaza Eurobuilding, Caracas, 18-21 Octubre 2000.

Cacabelos, R. Farmacogenética de la enfermedad de Alzheimer. XVIII Congreso Venezolano de Psiquiatría “Dr. Mauro Villegas”. Psiquiatría del Nuevo Milenio. Hotel Radisson Plaza Eurobuilding, Caracas, 18-21 Octubre 2000.

Cacabelos, R. Genómica: Repercusiones diagnósticas y terapéuticas. Simposio Internacional. Hacia una Sociedad Gerontológico. Universidad de Oviedo y Fundación Ramón Areces, Oviedo, 21-22 Noviembre, 2000.

1999

Fernández-Novoa, L., Mesa, M.D., Álvarez, X.A., Cacabelos, R. Genetic associations and risk factors in Alzheimer’s disease. Restauración Neurológica ’99, CIREN, Habana, 23-25 Feb., pp. 60 (1999).

Álvarez, X.A., Sampedro, C., Cacabelos, R. Antiapoptotic effects of CDP-choline in a combined (hypoperfusion + -amyloid) animal model of hippocampal neurodegeneration. Restauración Neurológica ’99, CIREN, Habana, 23-25 Feb., pp. 58 (1999).

Álvarez, X.A., Fernández-Novoa, L., Sampedro, C., Lombardi, V., Cacabelos, R., Windisch, M. Neuroimmunotrophic effects of cerebrolysin in an animal model of neurodegeneration induced by -amyloid. Restauración Neurológica ’99, CIREN, Habana, 23-25 Feb., pp. 58-59 (1999).

Cacabelos, R., Álvarez, X.A., Fernández-Novoa, L., Lombardi, V. Basic mechanisms of neuroprotection and genotype-related therapeutic response in Alzheimer’s disease: Implications for active treatment and prevention in dementia. Restauración Neurológica ’99, CIREN, Habana, 23-25 Feb., pp. 56 (1999).

Álvarez, X.A., Fernández-Novoa, L., Sampedro, C., Lombardi, V., Cacabelos, R., Windisch, M. Cerebrolysin reverses learning impairment and brain neuroimmune activation in an animal model of neurodegeneration induced by -amyloid. Keystone Symposia on Molecular & Cellular Biology. Molecular Mechanisms in Alzheimer’s Disease. Taos, New Mexico, March 3-9, pp. 48 (1999).

Lombardi, V.R.M., García, M., Rey, L., Cacabelos, R. Peripheral immunological abnormalities and lymphocyte dysfunction in Alzheimer disease. Keystone Symposia on Molecular & Cellular Biology. Molecular Mechanisms in Alzheimer’s Disease. Taos, New Mexico, March 3-9, pp. 52 (1999).

Fernández-Novoa, L., Lombardi, V., Mesa, M.D., Cacabelos, R. Genetic risk factors in Alzheimer disease and vascular dementia in the Spanish population. Keystone Symposia on Molecular & Cellular Biology. Molecular Mechanisms in Alzheimer’s Disease. Taos, New Mexico, March 3-9, pp. 35 (1999).

Cacabelos, R., Mesa, M.D., Fernández-Novoa, L. Association between genotypes and risk factors in Alzheimer’s disease. Keystone Symposia on Molecular & Cellular Biology. Molecular Mechanisms in Alzheimer’s Disease. Taos, New Mexico, March 3-9, pp. 35 (1999).

Cacabelos, R. Genética de la enfermedad de Alzheimer. Diagnóstico Molecular y Predictivo de Riesgo Familiar. Simposio Regional Norte-Sur APAL. Asociación Psiquiátrica de America Latina. Isla Margarita, Venezuela. Nov. 23-27, pp. 54-55 (1999).

Cacabelos, R. Tratamiento farmacológico de la demencia senil. Simposio Regional Norte-Sur APAL. Asociación Psiquiátrica de America Latina. Isla Margarita, Venezuela. Nov. 23-27, pp. 70-71 (1999).

Laredo, M., Couceiro, V., Pérez, P., Anido, R., Figueroa, J., García, E., Mantiñán, N.P., Álvarez, X.A., Cacabelos, R. Neurorehabilitación en traumatismos craneoencefálicos. I Congreso Nacional de Psicología Clínica y de la Salud. Orense, 23-27 Nov., pp. 140-141 (1999).

Laredo, M., Gómez, E., Gallo, E., Corzo, L., Couceiro, V., Anido, R., Pérez, P., Álvarez, X.A., Cacabelos, R. Evaluación de las funciones del lenguaje en la demencia senil. I Congreso Nacional de Psicología Clínica y de la Salud. Orense, 23-27 Nov., pp. 114-115 (1999).

Cacabelos, R. Cerebrolysin enhances brain bioelectrical activity alpha and improves memory performance in humans. Internal Meeting Research Initiative EBEWE. Graz, Austria. Sept. 23 (1999).

Cacabelos, R., Mesa, M.D., Fernández-Novoa, L. Genetic epidemiology of risk factors in Alzheimer’s disease. Human Genome Meeting. Brisbane, Australia, 27-30 March, pp. 26 (1999).

Mesa, M.D., Fernández-Novoa, L., Lombardi, V.R., Álvarez, X.A., Cacabelos, R. ADGT-Kit: A diagnostic aid for the analysis of genetic risk factors involved in the etiopathogenesis of Alzheimer’s disease and vascular dementia. Human Genome Meeting. Brisbane, Australia, 27-30 March, pp. 26 (1999).

Álvarez, X.A., Pichel, V., Pérez, P., Laredo, M., Corzo, L., Zas, R., Fernández-Novoa, L., Alcaraz, M., Sempere, J.M., Díaz, J., Cacabelos, R. A double-blind placebo-controlled study with anapsos in vascular dementia and Alzheimer disease. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 23 (1999).

Pérez, P., Corzo, L., Álvarez, X.A., Laredo, M., Cacabelos, R. Changes in brain bioelectrical activity associated with cognitive and behavioral function in dementia. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 27 (1999).

Corzo, L., Zas, R., Fernández-Novoa, L., Álvarez, X.A., Olano, M., Mesa, D., Cacabelos, R. Serum apolipoprotein E and lipid levels in vascular dementia and Alzheimer disease. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 30 (1999).

Laredo, M., Gómez, E., Gallo, E., Corzo, L., Álvarez, X.A., Cacabelos, R. Evaluation of language functions in senile dementia. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 35 (1999).

Laredo, M., Pérez, P., Couceiro, V., Anido, R., Corzo, L., Álvarez, X.A., Cacabelos, R. Sleep disorders in vascular dementia and Alzheimer disease. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 35 (1999).

Fernández-Novoa, L., Mesa, M.D., Olano, M., Lombardi, V., Álvarez, X.A., Cacabelos, R. Evaluation of the genetic profile in Alzheimer’s disease and vascular dementia. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 41 (1999).

Fernández-Novoa, L., Mesa, M.D., de Olano, M., Lombardi, V., Álvarez, X.A., Cacabelos, R. Genotype characterization in Alzheimer disease according to gender, disease expression and age at onset. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 41 (1999).

de Olano, M., Mesa, M.D., Blanco, A., Fernández-Novoa, L., Corzo, L., Cacabelos, R. Angiotensin-converting enzyme I/D polymorphism in cerebrovascular pathology. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 41 (1999).

Álvarez, X.A., Fernández-Novoa, L., Sampedro, C., Lombardi, V., Windisch, M., Cacabelos, R. Neuroimmunotrophic effects of Cerebrolysin in an animal model of hippocampal degeneration induced by -amyloid. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 43 (1999).

Álvarez, X.A., Sampedro, C., Cacabelos, R. CDP-Choline reduces neuronal apoptosis in rats with brain hypoperfusion and hippocampal -amyloid implants. 1st Int. Cong. Vascular Dementia. Geneva, 3-6 Oct., pp. 43 (1999).

1998

Cacabelos, R. Bioética asistencial del anciano con enfermedad neurodegenerativa. Prevención genética de la demencia. VI Jornadas Nacionales y II Jornadas Internacionales de Bioética. Envejecer cuando nace un siglo. Granada, Sept. 25-26, pp. 20-23 (1998).

Cacabelos, R. Enfermedad de Alzheimer. Etiopatogenia y tratamiento. Simposio Internacional. Enfermedad de Alzheimer, Del Diagnóstico al abordaje terapéutico integral. Wyeth, México, Feb. 28, pp. 35-52 (1998).

Cacabelos, R., Lao, J.I., Beyer, K., Sellers, M.A., Laredo, M., Alcaraz, M., Álvarez, X.A. Genotype-specific therapeutic response in Alzheimer disease with novel compounds: New designs in drug clinical trials and preventive strategies. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 24 (1998).

Khachaturian, Z., Radebaugh, T., Thal, L., Gauthier, S., Cacabelos, R, Sano, M., Leber, P. International Working Group on Prevention of Alzheimer’s Disease. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 60 (1998).

Álvarez, X.A., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Cacabelos, R. Intrahippocampal injections of -amyloid fragments impair learning and memory in rats. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 134 (1998).

Álvarez, X.A., Fernández-Novoa, L., Perea, J.E., Daniele, D., Cacabelos, R. Citicoline reverses learning impairment induced by -amyloid injections into the rat hippocampus. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 134 (1998).

Álvarez, X.A., Laredo, M., Corzo, L., Zas, R., Mouzo, R., Perea, J.E., Daniele, D., Cacabelos, R. Citicoline enhances memory performance in elderly subjects. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 135 (1998).

Álvarez, X.A., Sellers, M.A., Mouzo, R., Pichel, V., Pérez, P., Laredo, M., Caamaño, J.M., Corzo, L., Zas, R., Fernández-Novoa, L., Lao, J.l., Beyer, K., Alcaraz, M., Cacabelos, R. Effects of CDP-choline on cognitive function and brain bioelectrical activity and hemodynamic parameters in Alzheimer disease patients: A double-blind placebo-controlled study. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 135 (1998).

Álvarez, X.A., Sellers, M.A., Mouzo, R., Pichel, V., Pérez, P., Laredo, M., Caamaño, J.M., Corzo, L., Zas, R., Fernández-Novoa, L., Lao, J.I., Beyer, K., Alcaraz, M., Sempere, J.M., Díaz, J., Cacabelos, R. Double-blind randomized placebo-controlled study with anapsos in senile dementia. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 136 (1998).

Beyer, K., Lao, J.I., Fernández-Novoa, L., Cacabelos, R. V1481: A novel mutation in the predicted TM2 domain of the presenilin-2 gene in a Spanish patient with late-onset Alzheimer’s disease. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April l 5-18, pp. 139 (1998).

Cacabelos, R. Protocol for preventive intervention in dementia: Gene-specific therapeutic responses with multifactorial strategies (combined treatment). Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp, 140 (1998).

Corzo, L., Fernández-Novoa, L., Zas, R., Beyer, K., Lao, J.I., Laredo, M., Álvarez, X.A., Cacabelos, R. Serum ApoE and lipid levels according to APOE genotype in Alzheimer disease. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 141 (1998).

Fernández-Novoa, L., Corzo, L., Beyer, K., Zas, R., Lao, J.I., Laredo, M., Álvarez, X.A., Cacabelos, R. Histamine levels in Alzheimer’s disease and vascular dementia according to GDS staging. APOE genetic profile evaluation. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 142 (1998).

Lao, J.I., Beyer, K., Fernández-Novoa, L., Cacabelos, R. A possible epistasia between presenilin-l gene and APOE-E4 allele on Alzheimer disease in the Spanish population. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 149 (1998).

Laredo, M., Pichel, V., Álvarez, X.A., Mouzo, R., Pérez, P., Lao, J.I., Beyer, K., Novo, B., Alcaraz, M., Cacabelos, R. Influence of diagnosis and APOE genotype on cognitive performance in senile dementia: a prospective study. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 150 (1998).

Miguel-Hidalgo, J.J., Álvarez, X.A., Quack, G., Cacabelos, R. Protection by memantine against A(1-40)-induced neurodegeneration in the CA1 subfield. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 153 (1998).

Pérez, P., Pichel, V., Álvarez, X.A., Laredo, M., Mouzo, R., Lao, J.I., Beyer, K., Novo, B., Alcaraz, M., Cacabelos, R. Changes in brain bioelectrical activity associated with disease stage and APOE genotype in senile dementia. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 155 (1998).

Pichel, V., Caamaño, J.M., Mouzo, R., Álvarez, X.A., Pérez, P., Laredo, M., Alcaraz, M., Lao, J.I., Beyer, K., Sellers, A., Cacabelos, R. Changes in cerebral blood flow associated with disease staging and APOE genotype in patients with senile dementia. Fifth International Geneva/Springfield Symposium on Advances in Alzheimer Therapy. Geneva, April 15-18, pp. 156 (1998).

Cacabelos, R. Etiopatogenia da doença de Alzheimer e suas implicaçoes no tratamento. Simposium Envelhecimiento e Demencias. Coimbra, Portugal, Junho 26-27 (1998).

Beyer, K., Lao, J.I., Fernández-Novoa, L., Cacabelos, R. Identification of a novel mutation (V1481) in the TM2 domain of the presenilin-2 gene in a patient with late-onset Alzheimer disease. 6th International Conference on Alzheimer’s Disease and Related Disorders. Amsterdam, July l 8-23. Neurobiol. Aging, 19/4S:S87 (1998).

Cacabelos, R., Álvarez, X.A., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Lombardi, V. An animal model of neurodegeneration induced by injections of -amyloid into the rat hippocampus: Behavioral characterization. 6th International Conference on Alzheimer’s Disease and Related Disorders. Amsterdam, July 18-23. Neurobiol. Aging, 19/4S:S126 (1998).

Miguel-Hidalgo, J.J., Álvarez, X.A., Quack, G., Cacabelos, R. Protection of memantine against A(1-40)-induced neurodegeneration in the CA1 subfield. 6th International Conference on Alzheimer’s Disease and Related Disorders. Amsterdam, July 18-23. Neurobiol. Aging, 19/4S:S129 (1998).

Álvarez, X.A., Laredo, M., Corzo, L., Zas, R., Mouzo, R., Fernández-Novoa, L., Perea, J.E., Daniele, D., Cacabelos, R. Memory-enhancing effects of citicoline in elderly nondemented people. 6th International Conference on Alzheimer’s Disease and Related Disorders. Amsterdam, July 18- 23. Neurobiol. Aging, 19/4S:S184 (1998).

Mouzo, R., Álvarez, X.A., Sellers, M.A., Pichel, V.M., Pérez, P., Laredo, M., Caamaño, J.M., Corzo, L., Zas, R., Fernández-Novoa, L., Lao, J.I., Beyer, K., Alcaraz, M., Sempere, J.M., Díaz, J., Cacabelos, R. Treatment with anapsos in senile dementia: A double-blind placebo-controlled study. 6th International Conference on Alzheimer’s Disease and Related Disorders. Amsterdam, July 18- 23. Neurobiol. Aging, 19/4S:S184 (1998).

Lombardi, V., García, M., Cacabelos, R. Neuroimmunomodulation induced by cerebrolysin, a brain-derived peptide preparation, on primary microglial cell cultures. 6th International Conference on Alzheimer’s Disease and Related Disorders. Amsterdam, July 18-23. Neurobiol. Aging, 19/4S:S200 (1998).

Vigo-Pelfrey, C., Cacabelos, R., Álvarez, X.A., Allison, C. Neurostrol, a potent anti-inflammatory drug to treat Alzheimer’s disease. 6th International Conference on Alzheimer’s Disease and Related Disorders. Amsterdam, July 18-23. Neurobiol. Aging, 19/4S:S262 (1998).

Álvarez, X.A., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Cacabelos, R. Beta-amyloid injections into the rat hippocampus impair learning and memory. XXlst CINP Congress, Glasgow, July 12-16, pp. 391 (1998).

Álvarez, X.A., Fernández-Novoa, L., Perea, J.E., Cacabelos, R. Citicoline reverses learning impairment in rats with hippocampal neurodegeneration induced by beta-amyloid. XXlst CINP Congress, Glasgow, July 12-16, pp. 391 (1998).

Cacabelos, R., Miguel-Hidalgo, J.J., Álvarez, X.A., Quack, G. Protection of memantine against A(1-40)-induced neurodegeneration in the CA1 subfield. XXIst CNIP Congress, Glasgow, July 12- 16, pp. 392 (1998).

Cacabelos, R., Miguel-Hidalgo, J.J., Álvarez, X.A. Beta-amyloid-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield. XXlst CNIP Congress, Glasgow, July 12-16, pp. 392 (1998).

Cacabelos, R., Fernández-Novoa, L., Álvarez, X.A., Miguel-Hidalgo, J.J. Effects of hippocampal beta-amyloid injections on histamine levels, SOD, and AchE activities in the rat brain. XXlst CNIP Congress, Glasgow, July 12-16, pp. 392 (1998).

Álvarez, X.A., Fernández-Novoa, L., Perea, J.E., Daniele, D., Cacabelos, R. Citicoline antagonizes bromazepam-induced amnesia in rats. XXlst CMP Congress, Glasgow, July 12-16, pp. 396 (1998).

Cacabelos, R., Lombardi, V., García, M., Álvarez, X.A. Neuroimmunotrophic compounds from marine organisms. XXIst CNIP Congress, Glasgow, July 12-16, pp. 433 (1998).

1997

Beyer, K., Lao, J.I., Sellers, M.A., Álvarez, X.A., Cacabelos, R. Association between presenilin-l (S182) gene polymorphism and Alzheimer’s disease in the Spanish population. 4th Joint Clinical Genetics Meeting of the 28th Annual March of Dimes Clinical Genetics Conference and the American College of Medical Genetics 4th Annual Meeting. Ft. Lauderdale, Florida, pp. A50. Feb. 28-March 2 (1997).

Lao, J.I., Beyer, K., Cacabelos, R., De la Fuente, R. Three new mutations in the GTP-CHI gene in Spanish families with hereditary progressive and dopa-responsive dystonia. 4th Joint Clinical Genetics Conference of the 28th Annual March of Dimes Clinical Genetics Conference and the American College of Medical Genetics 4th Annual Meeting. Ft. Lauderdale, Florida, pp. A53 (1997).

A large GAA expanded allele in a family with Friedreich’s ataxia: A case report. 4th Joint Clinical Genetics Meeting of the 28th Annual March of Dimes Clinical Genetics Conference and the American College of Medical Genetics 4th Annual Meeting. Ft. Lauderdale, Florida, pp. A54. (1997).

Cacabelos, R. Etiopatogenia y estrategia terapéutica en la enfermedad de Alzheimer. I Symposium Alzheimer. Residencia Nuestra Señora del Carmen, Valencia (17.3.1997).

Cacabelos, R. Preventive strategies in Alzheimer’s Disease and Related Disorders: Genotyping and drug monitoring. International Workshop. The role of the glutamatergic system in neurodegeneration and dementia. Osaka. April 5 (1997).

Cacabelos, R. Therapeutic strategies in Alzheimer’s disease: Novel compounds with neuroimmunotrophic activity. International Workshop. Brain Aging and Alzheimer’s Disease. From Molecular to Clinical Approaches. Havana, April 10-12, pp. 14-15 (1997).

Cacabelos, R. Neuroimmune dysfunction in Alzheimer’s disease. International Workshop. Brain Aging and Alzheimer’s Disease. From Molecular to Clinical Approaches. Havana, April 10-12, pp. 15 (1997).

Cacabelos, R. Advances in brain histamine research. XXVI Annual Meeting. European Histamine Research Society, Seville, May 14-14 (1997).

Cacabelos, R., Lao, J.I., Beyer, K., Álvarez, X.A., Fernández-Novoa, L. Central and peripheral histamine in neurodegenerative and psychiatric disorders: genetic markers and histamine levels. XXVI Annual Meeting. European Histamine Research Society. Seville, May 14-17, pp. 10 (1997).

Fernández-Novoa, L., Álvarez, X.A., Miguel-Hidalgo, J.J., Cacabelos, R. Brain histamine in an animal model of neuronal degeneration. XXVI Annual Meeting. European Histamine Research Society, Seville, May 14-17, pp. 104 (1997).

Maneiro, E., Fernández-Novoa, L., Lombardi, V., Cacabelos, R. Effects of histamine on lactate dehydrogenase (LDH) release in cultured rat endothelial cells. XXVI Annual Meeting. European Histamine Research Society. Seville, May 14-17, pp. 105 (1997).

Fernández-Novoa, L., Corzo, L., Zas, R., Álvarez, X.A., Cacabelos, R. Whole blood and serum histamine in healthy subjects and in schizophrenic patients: Correlation analysis with transcranial Doppler ultrasonography. XXVI Annual Meeting. European Histamine Research Society. Seville, May 14-17, pp. 106 (1997).

Fernández-Novoa, L., Corzo, L., Zas, R., Álvarez, X.A., Cacabelos, R. Histamine levels in Alzheimer’s disease and vascular dementia patients according to Global Deterioration Scale Staging: Correlation studies with brain hemodynamic parameters. XXVI Annual Meeting. European Histamine Research Society. Seville, May 14-17, pp. 107 (1997).

Fernández-Novoa, L., Álvarez, X.A., Cacabelos, R. Effects of famotidine on the levels of blood histamine in healthy subjects: Correlation studies with brain mapping. XXVI Annual Meeting. European Histamine Research Society. Seville, May 14-17, pp. 108 (1997).

Fernández-Novoa, L., Álvarez, X.A., Cacabelos, R. Blood histamine levels in depression. XXVI Annual Meeting. European Histamine Research Society. Seville, May 14-17, pp. 109 (1997).

Mouzo, R., Álvarez, X.A., Sellers, A., Pichel, V., Lao, J.I., Caamaño, J.M., Laredo, M., Pérez, P., Beyer, K., Alcaraz, M., Rúa, M.C., Fernández-Novoa, L., Fernández, R., Carrera, C., Cacabelos, R. Blood pressure and apolipoprotein-E (APOE) in senile dementia. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May l 8-23, pp. 6 (1997).

Laredo, M., Álvarez, X.A., Mouzo, R., Pérez, P., Lao, J.I., Beyer, K., Sellers, A., Pichel, V., Caamaño, J.M., Rodríguez, S., Iglesias, E., Varela, B., Cacabelos, R. Psychometric evaluation and APOE genotyping in senile dementia. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 8 (1997).

Maneiro, E., Lombardi, V., Díaz, J., Cacabelos, R. Effects of anapsos on adult rat microglial cell cultures. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 10 (1997).

Sellers, A., Pérez, P., Rodríguez, B., Pichel, V.M., Caamaño, J.M., Laredo, M., Alcaraz, M., Álvarez, X.A., Cacabelos, R. Dementia-associated sleep disorders. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 12 (1997).

Pérez, L., Sellers, A., Caamaño, J.M., Lao, J.I., Beyer, K., Bustos, J.C., Cacabelos, R. Clinical evaluation at the onset of senile dementia. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 13 (1997).

Sellers, A., Carrera, C., Bustos, J.C., Caamaño, J.M., Rodríguez, B., Mouzo, R., Pérez, P., Lao, J.I., Beyer, K., Álvarez, X.A., Cacabelos, R. Cognitive and non-cognitive symptoms in senile dementia. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 13 (1997).

Maneiro, E., Lombardi, V., Cacabelos, R. Adult rat microglial cell cultures: An in vitro cellular model to study the effect of IL-1 and -amyloid on microglial activation. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 41 (1997).

Maneiro, E., Lombardi, V., Cacabelos, R. Rat endothelial cell cultures: An in vitro cellular model to study the cytotoxic effect of -amyloid, LPS, histamine and serum from AD patients on endothelial cell cultures. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 41 (1997).

Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R. -Amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 42 (1997).

Álvarez, X.A., Fernández-Novoa, L., Perea, J.E., Daniele, D., Cacabelos, R. Citicoline reverses learning impairment in rats with hippocampal injections of -amyloid (1-40). Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 42 (1997).

Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Hippocampal implants of -amyloid induce memory deficits in rats. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 43 (1997).

Cacabelos, R. Therapeutic strategies in Alzheimer’s disease: pleiotropic versus etiopathogenic treatment. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 48 (1997).

Beyer, K., Lao, J.I., Cacabelos, R. Allele differences in the presenilin-2 gene in Alzheimer’s disease. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 56 (1997).

Beyer, K., Lao, J.I., Cacabelos, R. A rapid and easy method for presenilin-1 gene screening. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 57 (1997).

Corzo, L., Fernández-Novoa, L., Zas, R., Beyer, K., Lao, J.I., Álvarez, X.A., Cacabelos, R. Influence of the APOE genotype on serum ApoE levels from Alzheimer’s disease patients in the Spanish population. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 59 (1997).

Pichel, V.M., Caamaño, J.M., Mouzo, R., Álvarez, X.A., Pérez, P., Laredo, M., Alcaraz, M., Lao, J.I., Beyer, K., Sellers, A., Cacabelos, R. Changes in cerebral blood flow associated with disease staging and APOE genotyping in patients with senile dementia. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 62 (1997).

Pérez, P., Álvarez, X.A., Laredo, M., Mouzo, R., Sellers, A., Pichel, V.M., Caamaño, J.M., Lao. J.I., Beyer, K., Novo, B., Alcaraz, M., Cacabelos, R. Brain activity mapping and APOE genotyping in senile dementia. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 62 (1997).

Lao, J.I., Beyer, K., Cacabelos, R. Centromere disturbances affecting Alzheimer’s disease lymphocyte metaphases. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 62 (1997).

Álvarez, X.A., Fernández-Novoa, L., Díaz, J., Sempere, J.M., Cacabelos, R. Anapsos improves learning and memory in rats with -amyloid(1-28) deposits into the hippocampus. Oholo 41st Conference. Progress in Alzheimer’s and Parkinson’s diseases. Fourth International Conference. Eilat, Israel, May 18-23, pp. 64 (1997).

Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R. Neuroprotection by CDP-choline in a model of hippocampal degeneration after deposits of fragment 1-40 of -amyloid. 6th World Congress Biological Psychiatry, June 22-27, Nice. Biol. Psychiatry, 42(1S):39S (1997).

Maneiro, E., Lombardi, V., Cacabelos, R. Cytotoxicity induced by -amyloid, histamine, LPS and serum from AD patients on rat endothelial cells. 6th World Congress Biological Psychiatry, June 22- 27, Nice. Biol. Psychiatry, 42(1S):90-91S (1997).

Maneiro, E., Lombardi, V., Cacabelos, R. -Amyloid and IL-1 effects on rat microglial cell cultures. 6th World Congress Biological Psychiatry. June 22-27, Nice. Biol. Psychiatry, 42(1S):91S (1997).

Sellers, A., Álvarez, X.A., Carrera, C., Bustos, J.C., Caamaño, J.M., Mouzo, R., Pérez, P., Lao, J.I., Beyer, K., Cacabelos, R. Cognitive and non-cognitive symptoms in patients with senile dementia. 6th World Congress Biological Psychiatry, June 22-27, Nice. Biol. Psychiatry 42(1S):93S (1997).

Álvarez, X.A., Fernández-Novoa, L., Perea, J.E., Daniele, D., Cacabelos, R. Citicoline antagonizes bromazepam-induced amnesia in rats. 6th World Congress Biological Psychiatry June 22-27, Nice. Biol. Psychiatry, 42(1S):95S (1997).

Álvarez, X.A., Laredo, M., Corzo, L., Perea, J.E., Daniele, D., Cacabelos, R. Citicoline improves memory in elderly subjects. 6th World Congress Biological Psychiatry, June 22-27, Nice. Biol. Psychiatry 42(1 S):95S (1997).

Lao, J.I., Beyer, K., Álvarez, X.A., Cacabelos, R. Analysis of a polymorphic tetranucleotide repeat in the TH gene in Spanish psychiatric patients. 6th World Congress Biological Psychiatry, June 22- 27, Nice. Biol. Psychiatry 42(1S):101S (1997).

Sellers, A., Álvarez, X.A., Rodríguez, B., Caamaño, J.M., Laredo, M., Pichel, V.M., Alcaraz, M., Cacabelos, R. Sleep disorders in patients with senile dementia. 6th World Congress Biological Psychiatry. June 22-27, Nice. Biol. Psychiatry, 42(1S): 115S (1997).

Beyer, K., Lao, J.I., Sellers, M.A., Álvarez, X.A., Cacabelos, R. Association between presenilin-l (S182) gene polymorphism and Alzheimer’s disease in the Spanish population. 6th World Congress Biological Psychiatry. June 22-27, Nice. Biol. Psychiatry 42(1S):120S (1997).

Fernández-Novoa, L., Corzo, L., Álvarez, X.A., Cacabelos, R. Whole blood and serum histamine in healthy subjects and schizophrenic patients: Correlation analysis with transcraneal Doppler ultrasonography. 6th World Congress Biological Psychiatry. June 22-27, Nice. Biol. Psychiatry, 42(1S):176-177S (1997).

Pichel, V.M., Caamaño, J.M., Mouzo, R., Álvarez, X.A., Pérez, P., Laredo, M., Alcaraz, M., Lao, J.I., Beyer, K., Sellers, A., Cacabelos, R. Cerebral blood flow in senile dementia: Changes associated with disease staging and APOE genotyping. 6th World Congress Biological Psychiatry. June 22-27, Nice. Biol. Psychiatry, 42(1S):211S (1997).

Cacabelos, R. Alzheimer’s disease: present and future. Symposium II. New vistas on CNS pharmacology. Innsbruck University, Innsbruck, Austria, Sept. 12 (1997).

Cacabelos, R. Etiopatogenia de la enfermedad de Alzheimer. XVII Congreso Venezolano de Psiquiatría. Nov. 5-8, Maracaibo (1997).

Cacabelos, R. Controversias en el tratamiento de la demencia. XVII Congreso venezolano de Psiquiatría. Nov. 5-8, Maracaibo (1997).

Cacabelos, R. Tratamiento farmacológico de las demencias: especificidad genotípica de las respuestas terapéuticas en la enfermedad de Alzheimer. XVII Congreso venezolano de psiquiatría. Nov. 5-8, Maracaibo (1997).

Lombardi, V., Cacabelos, R. Primary microglial cell cultures in the study of novel marine-derived compounds. 1st EuroConference on Marine Natural Products. Athens, Nov. 2-6, pp. 52 (1997).

Lombardi, V., Cacabelos, R. Biological effects of the fish extract E-CAB-9401l in rats. lst EuroConference on Marine Natural products. Athens, Nov. 2-6, pp. 120 (1997).

Lombardi, V., Cacabelos, R. E-JUR-94013 Marine fish extract: Neuroimmunological studies in adult Sprague-Dawley rats. lst EuroConference on Marine Natural Products. Athens, Nov. 2-6, pp. 121 (1997).

Lombardi, V., Reguera, R., Cacabelos, R. Neuroimmunological properties of Atlantic starfish-derived compounds. lst EuroConference on Marine Natural Products. Athens, Nov. 2-6, pp. 122 (1997).

Lombardi, V., Cacabelos, R. Neuroimmunological studies with the fish extract E-SAR-94010 in rats. lst EuroConference on Marine Natural Products. Athens, Nov. 2-6, pp. 123 (1997).

1996

Beyer, K., Lao, J.I., Fernández-Novoa, L., Franco-Maside, A., Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R. Allelic frequency of ApoE in the Spanish population. HGM´96. HUGO’s Human Genome Meeting, Heidelberg, March 22-24, pp. 11 (1996).

Lao, J.I., Beyer, K., Fernández-Novoa, L., Franco-Maside, A., Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R. Cytogenetic findings in Alzheimer’s disease. HGM’96. HUGO’s Human Genome Meeting, Heidelberg, 22-24 March, pp. 57 (1996).

Allain, H., Guez, D., Cacabelos, R., Derouesné, C., Jolles, J., Lenzi, G.L., Levy, R., Bruno, J., Neuman, E., Lepagnol, J. Safety and efficacy of S-12024 in patients with mild to moderate Alzheimer’s disease. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 74 (1996).

Cacabelos, R., Lagares, R., Fernández-Novoa, L., Franco-Maside, A., Miguel-Hidalgo, J.J., Álvarez, X.A. Anapsos: New therapeutic strategies for neurodegeneration and brain aging with natural neuroimmunotrophic factors. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 83 (1996).

Cacabelos, R., Vinagre, D., Caamaño, J., Lao, J.I., Beyer, K., Álvarez, X.A. Brain mapping and transcranial Doppler ultrasonography in Alzheimer disease drug monitoring. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 95 (1996).

Álvarez, X.A., Miguel-Hidalgo, J.J., Lagares, R., Franco, A., Fernández-Novoa, L., Lao, J.I., Díaz, J., Sempere, J.M., Cacabelos, R. Neuroprotective activity of anapsos in rats with hippocampal degeneration. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 130 (1996).

Álvarez, X.A., Franco, A., Fernández, L., Beyer, K., García, M., Polo, E., Desche, P., Guez, D., Cacabelos, R. Behavioral and neurochemical effects of S12024 in rats with implants of -amyloid into the hippocampus. Fourth lnternational Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 130 (1996)

Álvarez, X.A., Zas, R., García, M., Polo, E., Desche, P., Guez, D., Cacabelos, R. Comparative effects of S9977-2 vs Tacrine in learning and locomotion. Fourth lnternational Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 131 (1996).

Álvarez, X.A., Lagares, R., Franco, A., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Beyer, K., Cacabelos, R. Effects of CDP-choline in rats with brain neurotoxic lesions. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 131 (1996).

Beyer, K., Lao, J.I., Maneiro, E., Cacabelos, R, Alzheimer soluble factor (ASF): A potential peripheral marker for genetic Alzheimer disease. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 135 (1996).

Cacabelos, R., Caamaño, J., Gómez, M.J., Franco-Maside, A., Vinagre, D., Novo, B., Zas, R., Álvarez, X.A., Polo, E., García, M., Neuman, E., Guez, D. S-12024-2: A double-blind randomized placebo-controlled study in patients with Alzheimer disease. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 138 (1996).

Fernández-Novoa, L., Franco-Maside, A., Álvarez, X.A., Vecino, B., Díaz, J., Sempere, J.M., Cacabelos, R. Effects of anapsos on the activity of superoxide dismutase (SOD) in an animal model of neurodegeneration. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 143 (1996).

Fernández-Novoa, L., Vinagre, D., Franco-Maside, A., Caamaño, J., Álvarez, X.A., Cacabelos, R. Effects of famotidine on the levels of blood histamine in healthy subjects: Correlation studies with brain electrical activity mapping. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 143 (1996).

Lao, J.I., Beyer, K., Cacabelos, R. Senile dementia-associated FOS gene mutation in the Spanish population. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 156 (1996).

Maneiro, E., Lao, J.I., Beyer, K., Cacabelos, R. Microglia activation by an AD-associated 19kDa soluble factor. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 160 (1996).

Winblad, B., Ravizza, L., Rossor, M., Cacabelos, R. Research priorities in Alzheimer disease treatment- An international perspective. A European response. Fourth International Nice/Springfield Symposium on Advances in Alzheimer Therapy, Nice, April 10-14, pp. 16 (1996).

Beyer, K., Lao, J.I., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R. Allelic frequency of ApoE in the Spanish population. The Lancet Conference 1996. The challenge of the dementias, Edinburgh, April 25-26, pp. 38 (1996).

Cacabelos, R. Variaciones endocrinológicas en los trastornos psíquicos del anciano. XXI Congr. Nac. Soc. Esp. Geriatría y Gerontología. V Reun. Soc. Castellano-Leonesa, Salamanca, Junio 5-8, 1996.

Cacabelos, R. Etiopatogenia y prospecciones terapéuticas de la enfermedad de Alzheimer. Actualidad científica y sociosanitaria de la enfermedad de Alzheimer. Fundación Ramón Areces, Madrid, Junio 6, 1996.

Cacabelos, R. Función neuroinmunológica y endocrina en trastornos neurogeriátricos. Rev. Esp. Geriatría y Gerontología, 31: Supl. I (1996).

Sellers, A., Rodríguez, B., Cacabelos, R., Caamaño, J.M. Evaluación psicométrica de los trastornos del sueño en la demencia senil. Rev. Esp. Geriatría y Gerontología, 31:Supl. l (1996).

Fernández-Novoa, L., Corzo, L., Caamaño, J., Zas, R., Gómez, M.J., Álvarez, X.A., Cacabelos, R. Hemodinámica cerebral y niveles de histamina en enfermedad de Alzheimer y demencia vascular. Rev. Esp. Geriatría y Gerontología, 31:Supl. l (1996).

Beyer, K., Lao, J.I., Fernández-Novoa, L., Miguel-Hidalgo, J., Álvarez, X.A., Cacabelos, R. La frecuencia alélica del ApoE en la población gallega. Rev. Esp. Geriatría y Gerontología, 31:Supl. I (1996).

Maneiro, E., Cacabelos, R. Modificación de la microglía por un factor soluble del suero de pacientes con enfermedad de Alzheimer. Rev. Esp. Geriatría y Gerontología, 31:Supl. I (1996).

Álvarez, X.A., Fernández-Novoa, L., Zas, R., Lagares, R., Franco, A., Beyer, K., Maneiro, E., Cacabelos, R. Efectos de anapsos sobre función cerebral en ratones viejos. Rev. Esp. Geriatría y Gerontología, 31: Supl. I (1996).

Álvarez, X.A., Miguel-Hidalgo, J.J., Lagares, R., Franco, A., Fernández-Novoa, L., Beyer, K., Lao, J.l., Vecino, B., Díaz, J., Sempere, J.M., Cacabelos, R. Protective effects of anapsos in rats with hippocampal neurodegeneration. XXth CINP Congress, Melbourne, June 23-27, 1996. Eur. Neuropharmacol., 6(Suppl. 3):75 (1996),

Fernández-Novoa, L., Franco-Maside, A., Álvarez, X.A., Vecino, B., Díaz, J., Sempere, J,M., Cacabelos, R. Effects of anapsos on the activity of SOD in an animal model of neurodegeneration. XXth CINP Congress, Melbourne, June 23-27, 1996. Eur. Neuropharmacol., 6 (Supp1.3):193 (1996).

Franco-Maside, A., Fernández-Novoa, L., Álvarez, X.A., Vecino, B., Díaz, J., Sempere, J.M., Cacabelos, R. Effects of anapsos on brain histamine and 1L-1 levels in an animal model of neurodegeneration. XXth CINP Congress, Melbourne, June 23-27, l996. Eur. Neuropharmacol., 6 (Suppl.3):193 (1996).

Álvarez, X.A., Zas, R., Lagares, R., Franco, A., Fernández-Novoa, L., Díaz, J., Sempere, J.M., Cacabelos, R. Effects of anapsos on longevity, behavior and brain neurochemistry in mice. XXth CINP Congress, Melbourne, June 23-27, 1996. Eur. Neuropharmacol., 6(Suppl.3):193 (1996).

Miguel-Hidalgo, J.J., Álvarez, X.A., Lagares, R., Franco, A., Fernández. L., Cacabelos, R. Brain neurotoxic lesions in rats: Study of the neuroprotective effects of CDP-choline. XXth CINP Congress, Melbourne, June 23-27, 1996. Eur. Neuropharmacol., 6(Suppl.3): 193-194 (1996).

Álvarez, X.A., Zas, R., García, M., Polo, E., Guez, D., Cacabelos, R. Comparative effects of S- 9977-2 vs Tacrine on passive avoidance learning. XXth CINP Congress, Melbourne, June 23-27, 1996. Eur. Neuropharmacol., 6(Supp1.3):189-190 (1996).

Maneiro, E., Lao, J.l., Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R. Microglia activation by an AD-associated 19kDa soluble factor. Neurobiol. Aging, 17:S22 (1996).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Miguel-Hidalgo, J.J., García, M., Polo, E., Desche, P., Cacabelos, R. Neuroprotective effects of S12024 in rats with implants of -amyloid into the hippocampus. Neurobiol. Aging, 17:S28-29 (1996).

Cacabelos, R. Behavioral changes and biological markers associated with different genotypes in Alzheimer’s disease. Neurobiol. Aging, 17:S47 (1996).

Beyer, K., Lao, J.I., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Vecino, B., Álvarez, X.A., Cacabelos, R. A molecular genetic approach to Alzheimer’s disease from different genomic sites in the Spanish population. Neurobiol. Aging, 17:S60 (1996).

Lao, J.I., Beyer, K., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Vecino, B., Álvarez, X.A., Cacabelos, R. Cytogenetic signs of genomic instability in Alzheimer’s disease. Neurobiol. Aging, 17:S62-63 (1996).

Miguel-Hidalgo, J.J., Cacabelos, R. Subpopulations of rat Congo Red-staining neurons display distinct morphological features and altered distribution of -amyloid precursor protein immunoreactivity. Neurobiol. Aging, 17:S67 (1996).

Lagares, R., Álvarez, X.A., Franco, A., Fernández-Novoa, L., Beyer, K., Lao, J.I., Cacabelos, R. Behavioral deficits induced by stereotaxic -amyloid implants into the rat hippocampus. Neurobiol. Aging, 17:S68 (1996).

Cacabelos, R., Maneiro, E., Lagares, R., Lao, J.I., Beyer, K., Miguel-Hidalgo, J.J., Fernández-Novoa, L., Álvarez, X.A. Neuroimmunotrophic strategies in neurodegeneration and Alzheimer’s disease. Neurobiol. Aging, 17:S139-140 (1996).

Miguel-Hidalgo, J.J., Fernández-Novoa, L., Álvarez, X.A., Franco, A., Cacabelos, R. Characterization of a model of neuronal degeneration in the gyrus dentatus of the rat: Neuroprotective effects of anapsos. Neurobiol. Aging, 17:S140 (1996).

Álvarez, X.A., Fernández-Novoa, L., Caamaño, J., Vinagre, D., Gómez, M.J., Cacabelos, R. Effects of´ anapsos on brain function: Preclinical and clinical neuropharmacological studies. Neurobiol. Aging, 17:S140-141 (1996).

Fernández-Novoa, L., Corzo, L., Caamaño, J., Zas, R., Gómez, M.J., Álvarez, X.A., Cacabelos, R. Histamine and brain hemodynamics in Alzheimer disease and vascular dementia patients according to global deterioration scale staging. Neurobiol. Aging, 17:S184 (1996).

Cacabelos, R. Novel therapeutic strategies in Alzheimer’s disease. X World Congress of Psychiatry, Madrid, August 23-28, pp. 120 (1996).

Lao, J.I., Beyer, K., Álvarez, X.A., Cacabelos, R. Apo-E allelic frequency analysis in psychiatric disorders. X World Congress of Psychiatry, Madrid, August 23-28, pp. 195 (1996).

Beyer, K., Lao, J.I., Álvarez, X.A., Cacabelos, R. Rapid molecular detection of the fragile X gene trinucleotide repeat. X World Congress of Psychiatry, Madrid, August 23-28, pp. 197 (1996).

Miguel-Hidalgo, J.J., Álvarez, X.A., Fernández-Novoa, L., Díaz, J., Sempere, J.M., Cacabelos, R. Anapsos exerts neuroprotective effects in an animal model of neurodegeneration. X World Congress of Psychiatry, Madrid, August 23-28, pp. 211 (1996).

Cacabelos, R., Vinagre, D., Caamaño, J., Lao, J.I., Beyer, K., Álvarez, X.A. Brain mapping and transcranial Doppler ultrasonography in Alzheimer’s disease drug monitoring. X World Congress of Psychiatry, Madrid, August 23-28, pp. 212 (1996).

Cacabelos, R., Maneiro, E., Beyer, K., Lao, J.l., Miguel-Hidalgo, J.J., Álvarez, X.A. Effects of Alzheimer Apo-E-related ASF in microglia cell culture. X World Congress of Psychiatry, Madrid, August 23-28, pp. 213 (1996).

Miguel-Hidalgo, J.J., Vecino, B., Fernández-Novoa, L., Franco, A., Álvarez, X.A., Cacabelos, R. Neuroprotection by S-12024 in a model of neuronal degeneration in the rat hippocampus. X World Congress of Psychiatry, Madrid, August 23-28, pp. 216 (1996).

Miguel-Hidalgo, J.J., Álvarez, X.A., Lagares, R., Franco, A., Fernández, L., Cacabelos, R. Protective effects of CDP-choline against neurotoxic lesions in rat brain. X World Congress of Psychiatry, Madrid, August 23-28, pp. 216-217 (1996).

Lagares, R., Álvarez, X.A., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Franco, A., Cacabelos, R. Stereotaxic -amyloid implants into the hippocampus induce behavioral deficits in rats. X World Congress of Psychiatry, Madrid, August 23-28, pp. 217 (1996).

Lao, J.I., Beyer, K., Miguel-Hidalgo, J.J., Fernández-Novoa, L., Álvarez, X.A., Cacabelos, R. Apo-E allelic frequency and genetic risk calculation in Alzheimer’s disease. X World Congress of Psychiatry, Madrid, August 23-28, pp. 247 (1996).

Lagares, R., Álvarez, X.A., Zas, R., Franco, A., Fernández-Novoa, L., Cacabelos, R. Behavior and brain neuroimmune function in old mice treated chronically with anapsos. X World Congress of Psychiatry, Madrid, August 23-28, pp. 247 (1996).

Fernández-Novoa, L., Caamaño, J., Álvarez, X.A., Cacabelos, R. Correlation analysis between whole blood and serum histamine levels and transcranial Doppler ultrasonography parameters in healthy subjects and schizophrenic patients. X World Congress of Psychiatry, Madrid August 23-28, pp. 248 (1996).

Fernández-Novoa, L., Álvarez, X.A., Franco-Maside, A., Miguel-Hidalgo, J.J., Polo, E., Cacabelos, R. Effects of S-12024 in rats with hippocampal neurodegeneration. X World Congress of Psychiatry, Madrid, August 23-28, pp. 249 (1996).

Álvarez, X.A., Vara, E., Ayuso, J.L., Cacabelos, R. Effects of GHRP-6 on brain somatostatin levels in naive and cysteamine-treated rats. X World Congress of Psychiatry, Madrid, August 23- 28, pp. 249 (1996).

Lao, J.I., Beyer, K., Miguel-Hidalgo, J.J., Fernández-Novoa, L., Álvarez, X.A., Cacabelos, R Karyotypic figures found in Alzheimer’s disease patients. X World Congress of Psychiatry, Madrid, August 23-28, pp. 250 (1996).

Álvarez, X.A., Diéguez, C., Ayuso, J.L., Cacabelos, R. Learning impairment in rats with vitamin A-free diet: Influence on the testicular function. X World Congress of Psychiatry, Madrid, August 23-28, pp. 250-251 (1996).

Beyer, K., Lao, J.I., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R. Molecular genetic analysis of Alzheimer’s disease patients at Apo-E locus. X World Congress of Psychiatry, Madrid, August 23-28, pp. 251 (1996).

Álvarez, X.A., Ayuso, J.L., Cacabelos, R. The hexapeptide GHRP-6 improves passive avoidance learning in rats. X World Congress of Psychiatry, Madrid, August 23-28, pp. 253 (1996).

Cacabelos, R., Lagares, R., Fernández-Novoa, L., Franco-Maside, A., Miguel-Hidalgo, J.J., Álvarez, X.A. Anapsos: New therapeutic strategies for neurodegeneration and brain aging with natural neuroimmunotrophic factors. X World Congress of Psychiatry, Madrid, August 23-28, pp. 286 (1996).

Cacabelos, R., Caamaño, J., Gómez, M.J., Franco-Maside, A., Vinagre, D., Novo, B. S-12024-2: A double-blind randomized placebo-controlled study in patients with Alzheimer disease. X World Congress of Psychiatry, Madrid, August 23-28, pp. 315 (1996).

Sastre, I., Álvarez, X.A., Arauxo, A., Cacabelos, R. Standard operating procedures for filing documents in clinical trials. X World Congress of Psychiatry, Madrid, August 23-28, pp. 331 (1996).

Beyer, K., Lao, J.I., Fernández-Novoa, L., Miguel-Hidalgo, J.J., Álvarez, X.A., Cacabelos, R. Molecular identification of trinucleotide expansion causing Huntington’s disease without labelling with radionucleotides. X World Congress of Psychiatry, Madrid, August 23-28, pp. 342 (1996).

Cacabelos, R. Enfermedad de Alzheimer y otras demencias. Mesa Redonda. Máster Iberoamericano en Gerontología Social. Santiago de Chile. 10 Oct., (1996).

Cacabelos, R. Enfermedad de Alzheimer: Genética y Alternativas Terapéuticas. Jornada conmemorativa del Día Mundial del Alzheimer. Asociación de Familiares de Enfermos de Alzheimer. Tenerife, 21 Sept., (1996).

Cacabelos, R. Enfermedad de Alzheimer: Posibilidades preventivas y tratamiento. IV Jornadas de Información. “Enfermedad de Alzheimer”. Día Internacional del Alzheimer. Palencia, 17 Sept., (1996).

Cacabelos, R. Epidemiología y diagnóstico de las demencias. Mesa Redonda: Demencia Senil. Enfermedad de Alzheimer. Enfermedad de Alzheimer: Factores etiopatogénicos y diagnóstico clínico-molecular. Libro de Ponencias y Comunicaciones. III Congreso de la Medicina General Española. La Coruña, 17 Oct., pp. 28 (1996).

Sellers, M.A., Carrera, C., Bustos, J.C., Cacabelos, R. Evolución de la demencia senil según criterios clínicos. Libro de Ponencias y Comunicaciones. III Congreso de la Medicina General Española, La Coruña., pp. 302 (1996).

Sellers, M.A., Rodríguez, B., Caamaño, J.M., Cacabelos, R. Evaluación psicométrica de los trastornos del sueño en 231 pacientes con demencia senil. Libro de Ponencias y Comunicaciones. 111 Congreso de la Medicina General Española, La Coruña. pp. 304 (1996).

Sellers, M.A., Bustos, J.C., Pérez, L., Cacabelos, R. Rol del médico general en la asistencia al paciente demenciado. Libro de Ponencias y Comunicaciones. III Congreso de la Medicina General Española, La Coruña. pp. 306 (1996).

Álvarez, X.A., Fernández-Novoa, L., Corzo, L., Zas, R., Cacabelos, R. Cerebrovascular changes associated with interleukin-1 (IL-1) and histamine (HA) levels in Alzheimer’s disease. In: Cerebrovascular Pathology in Alzheimer’s disease. A New York Academy of Sciences Conference. New Jersey, 12-15 Nov., pp. 22 (1996).

Fernández-Novoa, L., Corzo, L., Zas, R., Álvarez, X.A., Cacabelos, R. Global Deterioration Scale-related brain haemodynamics and histamine levels in Alzheimer disease and vascular dementia. In: Cerebrovascular Pathology in Alzheimer’s disease. A New York Academy of Sciences Conference. New Jersey, 12-15 Nov., pp. 24 (1996).

Beyer, K., Lao, J.I., Fernández-Novoa, L., Álvarez, X.A., Sellers, M.A., Cacabelos, R. APOE E-4 allelic frequency in Alzheimer disease and vascular dementia in the Spanish population. In: Cerebrovascular Pathology in Alzheimer’s disease. A New York Academy of Sciences Conference. New Jersey, 12-15 Nov., pp. 31 (1996).

Cacabelos, R. Etiopatogenia y prospecciones terapéuticas de la enfermedad de Alzheimer. Actualidad Científica y Sociosanitaria de la enfermedad de Alzheimer. Fundación Ramón Areces, Madrid, l0 Jun. (1996).

Cacabelos, R. (Representación Ministerio de Sanidad ante UE) Alzheimer’s Disease and Related Disorders. European Conference. Limerick, Ireland, Nov. 20-22 (1996).

Cacabelos, R, Enfermedad de Alzheimer. Factores etiopatogénicos y evaluación genética. Programa de Formación Permanente. Federación Farmacéutica Valenciana. 10 Jun., (1996).

Cacabelos, R. Enfermedad de Alzheimer: Bases etiopatogénicas y estrategias terapéuticas. Simposio. Salud Mental y Psiquiatría en el umbral del nuevo milenio, I Reunión Regional Caribe y Países Bolivarianos “Carlos Alberto Seguín”. XIV Congreso Nacional de Psiquiatría “Honorio Delgado”. Lima 28 Nov.-1 Dic. (1996).

Cacabelos, R. Avances en Demencia (Parte I). Simposio. Salud Mental y Psiquiatría en el umbral del nuevo milenio. I Reunión Regional Caribe y Paises Bolivarianos “Carlos Alberto Seguín”. XIV Congreso Nacional de Psiquiatría “Honorio Delgado”. Lima, 28 Nov.-1 Dic. (1996).

Cacabelos, R. Avances en Demencia (Parte II). Simposio. Salud Mental y Psiquiatría en el umbral del nuevo milenio. I Reunión Regional Caribe y Paises Bolivarianos “Carlos Alberto Seguín”. XIV Congreso Nacional de Psiquiatría “Honorio Delgado”. Lima, 28 Nov.-1 Dic. (1996).

Cacabelos, R. Enfermedad de Alzheimer: Tratamientos Etiopatogénicos. III Reunión. Fundación Mapfre Medicina. Daño Cerebral y Calidad de Vida. Demencias. Madrid, 14-15 Nov (1996).

Cacabelos, R. La enfermedad de Alzheimer hoy. Tratamiento y prevención. Programa Aula Magna Tirso de Molina. Fundación Caja Rural. Soria. 11 Nov. (1996).

1995

Cacabelos, R. Bases etiopatogénicas de la enfermedad de Alzheimer. II Symposium Hispano- Americano. Avances en Psiquiatría. Facultad de Medicina. Universidad de Salamanca. Salamanca, 28-30 Marzo, 1995.

Cacabelos, R. Enfermedad de Alzheimer. Mesa Redonda. V Congreso de la Comunidad Valenciana para Médicos Rurales y Generalistas. Benicasim, 27-29 Abril, 1995.

Cacabelos, R. Enfermedad de Alzheimer. Predictores de un tratamiento etiopatogénico. IV Reunión de la Soc. de Psiquiatría de la Comunidad Valenciana. Hotel Castilla, Alicante 28-29 Abril, 1995,

Álvarez, X.A., Fernández-Novoa, L., Franco, A., Zas, R., Lagares, R., Sastre, I., Beyer, K., Lao, J.I., Miguel-Hidalgo, J.J., García, M., Guez, D., Cacabelos, R. Effects of S-9977-2 on learning and brain vasopressin in rats. Int. Symp. Alzheimer’s Res., Cambridge, UK, 4-7 July, 1995. Alzheimer’s Res., 1(Suppl. 1):120P (1995)

Miguel-Hidalgo, J.J., Maneiro, E., Franco, A., Álvarez, X.A., Cacabelos, R. Plastic effects of 1-28 amyloid -protein fragment deposits in the hippocampus with and without CDP-choline treatment. Int. Symp. Alzheimer’s Res., Cambridge, UK, 4-7 July 1995. Alzheimer’s Res., 1(Suppl. 1) :28 (1995).

Beyer, K., Lao, J.l., Álvarez, X.A., Franco, A., Cacabelos, R. Alzheimer’s disease genotyping in families at risk. Int. Symp. Alzheimer’s Res., Cambridge, UK, 4-7 July 1995. Alzheimer’s Res., 1(Suppl. 1):47 (1995).

Fernández-Novoa, L., Franco-Maside, A., Álvarez, X.A., Maneiro, E., Lagares, R., Miguel-Hidalgo, J.J., Beyer, K., Bullido, M.J., Valdivieso, F., Caamaño, J., Gómez, M.J., Vinagre, D., Cacabelos, R. APO-E genotyped patients with senile dementia: Correlations between plasma interleukin-1 and whole blood histamine. Int. Symp. Alzheimer’s Res., Cambridge, UK, 4-7 July 1995. Alzheimer’s Res., 1(Suppl. 1):50 (1995).

Cacabelos, R., Franco, A., Bullido, M.J., Recuero, M., Sastre, L., Zas, R., Álvarez, X.A., Lao, J.I., Beyer, K., Valdivieso, F. APO-E genotypes in Alzheimer’s disease and vascular dementia. Int. Symp. Alzheimer’s Res., Cambridge, UK, 4-7 July 1995. Alzheimer’s Res., 1(Suppl. 1):50 (1995).

Cacabelos, R., Vigo-Pelfrey, C., Franco-Maside, A., Lao, J.l., Beyer, K., Zas, R., Álvarez, X.A. Serum -amyloid levels in demented patients with different APO-E genotypes. Int. Symp. Alzheimer’s Res., Cambridge, UK, 4-7 July 1995. Alzheimer’s Res., 1 (Suppl. 1):51 (1995).

Álvarez, X.A., Zas, R., Lagares, R., Franco-Maside, A., Fernández-Novoa, L., Díaz, J., Cacabelos. R. Effects of the chronic administration of Anapsos on behavior in old mice. Int. Symp. Alzheimer’s Res., Cambridge, UK, 4-7 July 1995. Alzheimer’s Res., 1(Suppl. 1):53 (1995).

Álvarez, X.A., Fernández-Novoa, L., Franco, A., Zas, R., Lagares, R., Beyer, K., Lao, J.I., Miguel- Hidalgo, J.J., García, M., Guez, D., Cacabelos, R. Effects of S-9977-2 on learning and brain vasopressin levels in rats. Fourth IBRO World Congr. Neurosci., Kyoto, Japan, 9-14 July, pp. 376 (1995).

Miguel-Hidalgo, J.J., Lagares, R., Franco, A., Beyer, K., Lao, J.I., Álvarez, X.A., Cacabelos, R. Detection of bilateral neuronal degeneration after multiple lesions into the rat brain. Fourth IBRO World Congr. Neurosci., Kyoto, Japan, 9-14 July, pp. 246 (1995).

Álvarez, X.A., Fernández-Novoa, L., Franco, A., Zas, R., Lagares, R., Beyer, K., Lao, J.I., Miguel-Hidalgo, J.J., García, M., Guez, D., Cacabelos, R. Effects of S-12024-2 on brain vasopressin levels in rats. Fourth IBRO World Congr. Neurosci., Kyoto, Japan, 9-14 July, pp. 122 (1995).

Cacabelos, R. Demencia. Etiopatogenia. V Congr. Castellano-Leonés de Geriatría y Gerontología. Benavente, 29-30 Sept., 1995.

Cacabelos, R. Senile cognitive decline: Characterization of genotypic-phenotypic correlations in Alzheimer’s disease. Congr. Spanish Soc. Physiological Sciences & The Physiological Society, Salamanca, 2-5 Oct., 1995.

Cacabelos, R. CDP-Choline. Clinical experience. XI Conferencia Internacional. Alzheimer’s Disease International. Buenos Aires, 12-15 Sept., 1995.

Cacabelos, R., Franco-Maside, A., Bullido, M.J., Recuero, M., Sastre, I., Zas, R., Álvarez, X.A., Lao, J.I., Beyer, K., Valdivieso, F. Age- and sex-related APO-E genotypes in Alzheimer’s disease and vascular dementia. 1995 World Congress on Psychiatric Genetics. Psychiatric Genetics 5:S70 (1995).

Beyer, K., Lao, J.I., Álvarez, X.A., Cacabelos, R. Rapid molecular detection of the fragile X gene trinucleotide repeat. 1995 World Congress on Psychiatric Genetics. Psychiatric Genetics 5:S85 (1995).

Álvarez, X.A., Zas, R., Lagares, R., Franco-Maside, A., Fernández-Novoa, L., Díaz, J., Cacabelos, R. Chronic Anapsos administration improves psychomotor functioning in old mice. 7th IPA Congress, Sydney, 29 Oct.-3 Nov., 1995.

Miguel-Hidalgo, J.J., Maneiro, E., Álvarez, X.A., Lagares, R., Franco, A., Fernández-Novoa, L., Lao, J.I., Beyer, K., Cacabelos, R. Effects of 1-28 AP deposits in the hippocampus with and without CDP-choline treatment. 7th IPA Congress, Sydney, 29 Oct.-3 Nov., 1995.

Beyer, K., Lao-Villadóniga, J.I., Zas, R., Franco-Maside, A., Lagares, R., Miguel-Hidalgo, J.J., Maneiro, E., Álvarez, X.A., Cacabelos, R. A rapid molecular characterization of Alzheimer’s disease. 7th IPA Congress, Sydney, 29 Oct.-3 Nov., 1995.

Cacabelos, R., Franco, A., Bullido, M.J., Recuero, M., Sastres, I., Zas, R., Álvarez, X.A., Lao, J.I., Beyer, K., Valdivieso, F. APO-E genotypes in Alzheimer’s disease and vascular dementia. 7th IPA Congress, Sydney, 29 Oct.-3 Nov., 1995.

Vigo-Pelfrey, C., Álvarez, X.A., Franco-Maside, A., Cacabelos, R. Serum -Amyloid levels in Alzheimer’s disease and vascular dementia. 7th IPA Congress, Sydney, 29 Oct.-3 Nov., 1995.

Cacabelos, R. Pharmacological treatment of memory disorders. International Conference in Neuropsychiatry. Restoring Brain Function. A Multidisciplinary Approach. The University of Illinois, Chicago, 1-2 Dec., 1995.

1994

Cacabelos, R. Nuevas alternativas terapéuticas en las demencias. III Symposium Taller Internacional. Psiquiatría, Esquizofrenia y Demencias. Año 2000. Tenerife, 28-30 Abril, 1994.

Cacabelos, R. Psicofármacos convencionales en psicogeriatría. III Symposium Taller Internacional. Psiquiatría, Esquizofrenia y Demencias. Año 2000. Tenerife 28-30 Abril, 1994.

Cacabelos, R. New strategies for Alzheimer’s disease treatment: Pleiotropic drugs and multifactorial intervention. Third International Springfield Symposium on Advances in Alzheimer therapy. May 11-15, Springfield, Illinois, pp. 103 (1994).

Caamaño, J., Gómez, M.J., Franco, A., Álvarez, X.A., Fernández-Novoa, L., Novo, B., Vinagre, D., Cacabelos, R. Cerebrovascular and cognitive effects of CDP-choline in patients with Alzheimer’s disease. Third International Springfield Symposium on Advances in Alzheimer Therapy. May 11-15, Springfield, Illinois, pp. 119 (1994).

Franco-Maside, A., Caamaño, J., Gómez, M.J., Vinagre, D., Álvarez, X.A., Fernández-Novoa, L., Novo, B., Zas, R., Cacabelos, R. Effects of CDP-choline in brain electrical activity mapping and cerebral blood flow velocities in Alzheimer’s disease. Third International Springfield Symposium on Advances in Alzheimer Therapy. May 11-l5, Springfield, Illinois, pp. 120 (1994).

Álvarez, X.A., Fernández-Novoa, L., Zas, R., Caamaño, J., Novo, B., Diaz, J., Sempere, J.M., Cacabelos, R. Effects of Anapsos on behavior and brain neuroimmune factors in rats with neurotoxic lesions in the nucleus basalis of Meynert. Third International Springfield Symposium on Advances in Alzheimer Therapy. May 11-l5, Springfield, Illinois, pp. 122 (1994).

Fernández-Novoa, L., Álvarez, X.A., Zas, R., Gómez, M.J., Vinagre, D., Sada. G., Cacabelos, R. Effects of Polipodium leucotomos (Difur) on behavior and the hippocampal levels of interleukin-1, histamine and tumor necrosis factor in nbM-lesioned rats. Third International Springfield Symposium on Advances in Alzheimer Therapy. May 11-15, Springfield, Illinois, pp. 122 (1994).

Cacabelos, R., Fernández-Novoa, L., Álvarez, X.A. Brain histamine in aging and senile dementia. XXIIIrd Annual Meeting European Histamine Res. Soc., Budapest, May 18-21, pp. 4 (1994).

Fernández-Novoa, L., Zas, R., Deslandes, A., Polo, E., Álvarez, X.A., Cacabelos, R. Time- and dose-dependent changes induced by S-9977-2 in brain histamine. XXIIIrd Ann. Meet. Eur. Histamine Res. Soc., Budapest, May 18-21, 1994.

Cacabelos, R., Franco-Maside, A., Caamaño, J., Zas, R., Novo, B., Fernández-Novoa, L., Álvarez, X.A. CDP-choline reduces blood histamine levels in Alzheimer’s disease patients. XXIIIrd Ann. Meet. Eur. Histamine Res. Soc., Budapest, May 18-21, 1994.

Álvarez, X.A., Fernández-Novoa, L., Zas, R., Cacabelos, R. Effects of neurotoxic lesions in the nucleus basalis of Meynert on brain histamine. XXIIIrd Ann. Meet Eur. Histamine Res. Soc., Budapest, May 18-21, 1994.

Caamaño, J., Franco-Maside, A., Cacabelos, R. Blood histamine correlates with cerebrovascular parameters and quantitative EEG in Alzheimer’s disease. XXIIIrd Ann. Meet. Eur. Histamine Res. Soc., Budapest, May 18-21, 1994.

Cacabelos, R. Enfermedad de Alzheimer. V Symposium Internacional. Centro Neuropsiquiátrico “Sagrado Corazón”. Martorell, Barcelona, 16-18 Junio, 1994.

Cacabelos, R., Sempere, J.M. Factores etiopatogénicos en la enfermedad de Alzheimer. Función inmune. Jornada de Formación Biomédica. Introducción al tratamiento neuroinmune y neurotrófico en la enfermedad de Alzheimer. Colegio Médicos, Alicante, 10 Junio, 1994.

Cacabelos, R. Estrategias terapéuticas en la enfermedad de Alzheimer. Jornada de Formación Biomédica. Introducción al tratamiento neuroinmune y neurotrófico en la enfermedad de Alzheimer. Colegio Médicos, Alicante, 10 Junio, 1994.

Cacabelos, R. Biological markers and the cholinergic hypothesis in Alzheimer’s disease. Putative mechanisms of action of Tacrine. Advances in the management of Alzheimer’s disease. The role of Tacrine. Satellite Symposium. Fourth Meet. Eur. Neurol. Soc., Barcelona, 29 June, 1994.

Fernández-Novoa, L., Caamaño, J., Franco-Maside, A., Álvarez, X.A., Cacabelos, R. Blood histamine correlates with cerebrovascular parameters and brain electrical activity mapping in Alzheimer’s disease. XIXth CINP, Washington DC, June 27-July 1, 1994. Neuropsychopharmacology, 10/3S/Part 2/May, pp. 215S (1994).

Fernández-Novoa, L., Álvarez, X,A., Cacabelos, R. CDP-choline-induced blood histamine changes in Alzheimer’s disease. XIXth CINP, Washingon DC, June 27-July l, 1994. Neuropsychopharmacology, 10/3S/Part 2/May, pp. 131S (1994).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Zas, R., Cacabelos, R. Effects of Anapsos on behavior and brain interleukin-1. XIXth CINP, Washingon DC, June 27-July 1, 1994. Neuropsychopharmacology, 10/3S/Part 2/May, pp. 38S (1994).

Cacabelos, R., Fernández-Novoa, L., Zas, R., Deslandes, A., García, M., Álvarez, X.A. Time- and dose-dependent effects of S-9977-2 on brain histamine. XIXth CINP, Washingon DC, June 27- July 1, 1994. Neuropsychopharmacology, 10/3S/Part 2/May, 147S (1994).

Franco-Maside, A., Caamaño, J., Gómez, M.J., Cacabelos, R. Brain mapping activity and mental performance after chronic treatment with CDP-choline in Alzheimer’s disease. XIX CINP, Washingon DC, June 27-July l, 1994. Neuropsychopharmacology, 10/3S/Part 2/May, 216S (1994).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Zas, R., Kamoun, A., Polo, E., García, M., Cacabelos, R. Behavioral and neuroimmune effects of S-9977-2. XIXth CINP, Washingon DC, June 27-July l, 1994. Neuropsychopharmacology, 10/3S/Part 2/May, 39S (1994).

Cacabelos, R. Therapy for two symptoms of Alzheimer’s disease. Roundtable: Treating Alzheimer’s disease: present potential and future prospects. University of Minnesota. Accreditation Council for Continuing Medical Education. 4th Int. Conf. Alzheimer’s Disease and Related Disorders. Minneapolis, July 20-August 3, 1994.

Álvarez, X.A., Franco-Maside, A., Fernández-Novoa, L., Caamaño, J., Gómez, M.J., Novo, B., Zas, R., Cacabelos, R. Blood levels of histamine, interleukin-1 and tumor necrosis factor in Alzheimer’s disease. 4th Int. Conf. Alzheimer’s Disease and Related Disorders. Minneapolis, July 20-August 3, 1994. Neurobiol. Aging, 15(Suppl.1):S93 (1994).

Caamaño, J., Gómez, M.J., Vinagre, D., Franco, A., Fernández-Novoa, L., Álvarez, X.A., Zas, R., Novo, B., Cacabelos, R. Hemodynamic parameters of the middle cerebral artery in cerebrovascular disorders and senile dementia: A transcranial Doppler study. 4th Int. Conf. Alzheimer’s Disease and Related Disorders. Minneapolis, July 29-August 3, 1994. Neurobiol. Aging, 15 (Suppl.1):S96 (1994).

Franco-Maside, A., Caamaño, J., Vinagre, D., Gómez. M.J., Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Brain electrical activity mapping correlates with cerebral blood flow velocity in Alzheimer’s disease. 4th Int. Conf. Alzheimer’s Disease and Related Disorders. Minneapolis, July 29-August 3, 1994. Neurobiol. Aging, 15(Suppl.1):S98 (1994).

Gómez, M.J., Caamaño, J., Vinagre, D., Franco, A., Fernández-Novoa, L., Álvarez, X., Zas, R., Novo, B., Cacabelos, R. Cognitive and non-cognitive profiles in cerebrovascular disorders and senile dementia: A neuropsychological study. 4th Int. Conf. Alzheimer’s Disease and Related Disorders. Minneapolis, July 29-August 3, 1994. Neurobiol. Aging, 15(Suppl.1);S106 (1994)

Fernández-Novoa, L., Franco-Maside, A., Álvarez, X.A., Caamaño, J., Gómez, M.J., Zas, R., Cacabelos, R. Histamine, interleukin- IO and tumor necrosis factor correlate with brain electrical activity mapping in Alzheimer’s disease. 4th Int. Conf. Alzheimer’s Disease and Related Disorders. Minneapolis, July 29-August 3, 1994. Neurobiol. Aging, 15 (Suppl.l):S l21 (1994).

Cacabelos, R., Álvarez, X.A., Fernández-Novoa, L. Brain tumor necrosis factor alpha (TNF) in Alzheimer’s disease (AD). 4th Int. Conf. Alzheimer’s Disease and Related Disorders. Minneapolis, July 29-August 3, 1994. Neurobiol. Aging, 15(Suppl.1):S152 (1994).

Álvarez, X.A., Fernández-Novoa, L., Zas, R., Vinagre, D., Gómez, M.J., Sada, G., Cacabelos, R. Effects of polipodium leucotomos (Difur) on behavioral parameters and brain neuroimmune factors in nbm-lesioned rats. ECNP, Jerusalem, Oct. 16-21, 1994.

Álvarez, X.A., Fernández-Novoa, L., Zas, R., Franco, A., Kamoun, A., Deslandes, A., Polo, E., Gorostiaga, C., Cacabelos, R. S-9977-2 normalizes behavior and brain interleukin-1 levels in rats with lesions in the nucleus basalis of Meynert. ECNP, Jerusalem, Oct. 16-21, 1994.

Álvarez, X.A., Fernández-Novoa, L., Zas, R., Caamaño, J., Novo, B., Díaz, J., Sempere, J.M., Cacabelos, R. Behavioral and neuroimmune effects of anapsos in cognitively-impaired rats. ECNP. Jerusalem, Oct. 16-21, 1994.

Álvarez, X.A., Fernández-Novoa, L., Zas, R., Cacabelos, R. Effects of scopolamine on behavior and brain neuroimmune factors in rats. 17th Ann. Meet. Eur. Neurosci. Assoc., Vienna, 4-8 Sept., pp. 95 (1994).

Álvarez, X.A., Fernández-Novoa, L., Zas, R., Vinagre, D., Sada, G., Cacabelos, R. Effects of polipodium leucotomos (Difur) on behavior and brain neuroimmune factors in nbM-lesioned rats. 17th Ann. Meet. Eur. Neurosci. Assoc., Vienna, 4-8 Sept., pp. 99 (1994).

Caamaño, J., Gómez, M.J., Vinagre, D., Franco, A., Fernández-Novoa, L., Álvarez, X.A., Zas, R., Novo, B., Cacabelos, R. Hemodynamic parameters of the middle cerebral artery in cerebrovascular disorders and senile dementia. 17th Ann. Meet. Eur. Neurosci. Assoc., Vienna, 4-8 Sept., pp. l l0 (1994).

Vinagre, D., Franco-Maside, A., Caamaño, J., Gómez, M.J., Álvarez, X.A., Fernández-Novoa, L., Novo, B., Zas, R., Cacabelos, R. Brain electrical activity mapping in senile dementia and cerebrovascular disorders. 17th Ann. Meet. Eur. Neurosci. Assoc., Vienna, 4-8 Sept., pp. 110 (1994).

Cacabelos, R., Franco, A., Fernández-Novoa, L., Zas, R., Díaz, J., Sempere, J.M., Álvarez, X.A. Behavioral and neuroimmune effects of Anapsos in intact and nbM-lesioned rats. IBC’s Third Annual Alzheimer’s Disease. Advances in Understanding and treatment. Philadelphia, 22-23 Sept. (1994).

Cacabelos, R., Fernández-Novoa, L., Zas, R., Franco-Maside, A., Deslandes, A., García, M., Kamoun, A., Álvarez, X.A. Effects of S-9977-2 on behavior and brain neuroimmune factors in rats. IBC’s Third Annual Alzheimer’s Disease. Advances in Understanding and Treatment. Philadelphia, 22-23 Sept. (1994).

Cacabelos, R., Caamaño, J., Gómez, M.J., Álvarez, X.A., Novo, B., Zas, R., García, M., Polo, E., Malbezin, M., Neuman, E., Guez, D. Effects of S-I2024-2 on cognition, brain mapping and cerebrovascular parameters in Alzheimer’s disease. IBC’s Third Annual Alzheimer’s Disease. Advances in Understanding and Treatment. Philadelphia, 22-23 Sept. (1994).

1993

Cacabelos, R., Álvarez, X.A., Franco-Maside, A., Fernández- Novoa, L., Caamaño, J., Valle-lnclán, F. Effect of CDP-Choline on cognition and immune function in Alzheimer’s disease and multi-infarct dementia. Proc. 7th Meeting International Study Group on the Pharmacology of memory disorders associated with aging. Alzheimer’s disease: Amyloid precursor proteins, signal transduction, and neural transplantation. Nitsch, R.M., Growdon, J.H., Corkin, S., Wurtman, R.J., Zürich, Switzerland, Feb. 12-14; pp. 391-393 (1993).

Cacabelos, R. Biomedical aspects of Alzheimer’s disease: Introductory remarks. International Workshop on Alzheimer’s disease: Progress for the next decade. Fundación Ramón Areces, March 22-23, 1993.

Cacabelos, R. New trends for an etiopathogenic therapy in Alzheimer’s disease. lnternational Workshop on Alzheimer’s disease: Progress for the next decade. Fundación Ramón Areces. March 22-23, l993.

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Novo, B., Rettori, M.C., García, M., Cacabelos, R. Effects of S-9977-2 on learning and behavior in rats with neurotoxic lesions in the nucleus basalis of Meynert (NBM). Recent advances in the treatment of neurodegenerative disorders and cognitive dysfunction. Collegium Internationale Neuro-Psychopharmacologicum (CINP) President’s Workshop. Capri (Italy), May 1-3, 1993. pp. 125 (1993).

Gómez, M.J., Cacabelos, R. Alzheimer’s Disease Assessment Scale in control elderly subjects and in patients with Alzheimer’s disease or multi-infarct dementia. Recent advances in the treatment of neurodegenerative disorders and cognitive dysfunction. CINP. President’s Workshop. Capri (Italy), May 1-3, pp. 141 (1993).

Franco-Maside, A., Caamaño, J., Gómez, M.J., Álvarez, A., Fernández-Novoa, L., Novo, B., Cacabelos, R. CDP-Choline-induced brain mapping changes in patients with Alzheimer’s disease. Recent advances in the treatment of neurodegenerative disorders and cognitive dysfunction. CINP. President’s Workshop. Capri (Italy), May 1-3, pp. 154 (1993).

Caamaño, J., Franco, A., Gómez, M.J., Novo, B., Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Acute effects of CDP-Choline on middle cerebral artery blood flow velocities in Alzheimer’s disease: A transcranial Doppler study. Recent advances in the treatment of neurodegenerative disorders and cognitive dysfunction. CINP. President’s Workshop. Capri (Italy), May 1-3, pp. 155 (1993).

Cacabelos, R, Perspectivas actuais do tratamento da demencia de Alzheimer. Demencias: Avanços recentes. Actualizaçao nos aspectos bioquímicos, clínicos e terapéuticos. Hospital de Universidade de Coimbra. Coimbra, Portugal, May 8, 1993.

Cacabelos, R. Enfermedad de Alzheimer: Estrategias diagnósticas y terapéuticas. VIII Congr. Soc. Castellano-leonesa Cantabra de Medicina Interna. Zamora, Mayo 14-15, 1993. Anales Medicina Interna, Extra II, Mayo, pp. 19 (1993).

Cacabelos, R. Role of histamine and interleukin-1 in the neuroimmune dysregulation occurring in Alzheimer’s disease. Eur. Histamine Res. Soc., Cologne, Germany, May 19-22, pp. 7 (1993).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Effects of neurotoxic lesions in histaminergic neurons on psychomotor activity and learning. Eur. Histamine Res. Soc., Cologne, Germany, May 19-22, pp. 70 (1993).

Fernández-Novoa, L., Franco, A., Álvarez, X.A., Cacabelos, R. Changes in serum histamine and tumor necrosis factor (TNF) from patients with Alzheimer’s disease and multi-infarct dementia. Eur. Histamine Res. Soc., Cologne, Germany, May 19- 22, pp. 89 (1993).

Fernández-Novoa, L., Franco, A., Lodeiro, C., Álvarez, X.A., Cacabelos, R. Effects of histamine and alpha-fluoromethylhistidine on brain tumor necrosis factor levels. Eur. Histamine Res. Soc., Cologne, Germany, May 19-22, pp. 90 (1993).

Franco, A., Fernández-Novoa, L., Lodeiro, C., Álvarez, X.A., Cacabelos, R. Effects of histamine and antihistaminics on the hippocampal levels of interleukin-1 in rats. Eur. Histamine Res. Soc., Cologne, Germany, May 19-22, pp. 91 (1993).

Fernández-Novoa, L., Franco, A., Álvarez, X.A., Cacabelos, R. Effects of neurotoxic lesions in histaminergic neurons on brain tumor necrosis factor. Eur. Histamine Res. Soc., Cologne, Germany, May 19-22, pp. P-86 (1993).

Caamaño, J., Valle-lnclán, F., Cacabelos, R. Blood flow velocity in multi-infarct dementia and Alzheimer’s disease studied by transcranial Doppler ultrasonography. World Congr. Gerontology. XVth Congr. Intern. Assoc. Gerontology, Budapest, July 4-9, pp. 301 (1993).

Álvarez, X.A., Franco, A., Novo, B., Fernández-Novoa, L., Cacabelos, R. Age-dependent serum interleukin-1 beta levels in healthy control subjects. World Congr. Gerontology. XVth Congr. Intern. Assoc. Gerontology, Budapest, July 4-9, pp. 302 (1993).

Cacabelos, R., Fernández-Novoa, L., Pérez-Trullén, J.M., Franco, A., Álvarez, X.A. Serum tumor necrosis factor (TNF) in Alzheimer’s disease (AD) and multi-infarct dementia (MID). World Congr. Gerontology. XVth Congr. Intern. Assoc. Gerontology, Budapest, July 4-9, pp. 302 (1993).

Gómez, M.J., Álvarez, X.A., Cacabelos, R. Dementia mood assessment scale in elderly controls and in patients with depression and/or dementia. World Congr. Gerontology. XVth Congr. Intern. Assoc. Gerontology, Budapest, July 4-9, pp. 302 (1993).

Cacabelos, R. Bases bioquímicas del trastorno afectivo bipolar. XVII Reunión Nacional Soc. Esp. Psiquiat. Biol., Salamanca, Junio 16-19 (1993).

Caamaño, J., Franco, A., Gómez, M.J., Novo, B., Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Cerebrovascular effects of CDP-choline in patients with Alzheimer’s disease: A transcranial Doppler study. Sixth Congr. Intern. Psychogeriat. Assoc. (IPA), Berlin, Sept. 5-10, 1993.

Gómez, M.J., Cacabelos, R. Alzheimer’s disease assessment scale in control elderly subjects and in patients with senile dementia. Sixth Congr. Intern. Psychogeriat. Assoc. (IPA), Berlin, Sept. 5-10, 1993.

Franco-Maside, A., Caamaño, J., Cacabelos, R. Brain electrical activity mapping correlates with cerebral blood flow velocity in Alzheimer’s disease. Sixth Congr. Intern. Psychogeriat. Assoc. (IPA), Berlin, Sept. 5-10, 1993.

Cacabelos, R., Miller, D., Álvarez, X.A., Fernández-Novoa, L., Franco-Maside, A., Nishimura, T., Pearson, J. Brain interleukin-1 in Alzheimer’s disease and vascular dementia. Sixth Congr. Intern. Psychogeriat. Assoc. (IPA), Berlin, Sept. 5-10, 1993.

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Effects of Anapsos on psychomotor activity, passive avoidance behavior and brain interleukin-1 levels. Sixth Congr. Intern. Psychogeriat. Assoc. (IPA), Berlin, Sept. 5-10, 1993.

Álvarez, X.A., Franco, A., Rettori, M.C., Polo, E., García, M., Cacabelos, R. Effects of S9977-2 on behavior and brain interleukin-1 levels in an animal model of cognitive impairment. Sixth Congr. Intern. Psychogeriat. Assoc. (IPA), Berlin, Sept. 5-10, 1993.

Caamaño, J., Franco, A., Gómez, M.J., Novo, B., Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Cerebrovascular effects of CDP-choline in patients with Alzheimer’s disease: Hemodynamic parameters measured by transcranial Doppler ultrasonography. 16th Ann. Meeting Eur. Neurosci. Assoc., Madrid, Sept. 18-21, pp. 88, 1993.

Franco-Maside, A., Caamaño, J., Cacabelos, R. Brain electrical activity mapping correlates with cerebral blood flow velocity in Alzheimer’s disease. 16th Ann. Meeting Eur. Neurosci. Assoc., Madrid, Sept. 18-21, pp. 89, 1993.

Álvarez, X.A., Fernández-Novoa, L., Franco, A., Cacabelos, R. Influence of brain histamine on interleukin-1 production in the hypothalamus and hippocampus. 16th Ann. Meeting Eur. Neurosci. Assoc., Madrid, Sept. 18-21, pp. 169, 1993.

Fernández-Novoa, L., Álvarez, X.A., Franco-Maside, A., Caamaño, J., Cacabelos, R. CDP-choline-induced changes in blood histamine in patients with Alzheimer’s disease. 16th Ann. Meeting Eur. Neurosci. Assoc., Madrid, Sep. 18-21, pp. l l8, 1993.

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Rettori, M.C., García, M., Cacabelos, R. Time- and dose-dependent effects of S9977 on behavior and brain interleukin-1. First Int. Congr. on Hormones, Brain and Neuropharmacology, Rhodes, Sept. 13-17, 1993. Neuropsychopharmacology 9/2S:78S (1993).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Effects of Anapsos on behavior and brain neuroimmune factors. First Int. Congr. on Hormones, Brain and Neuropsychopharmacology, Rhodes, Sept. 13-17, 1993. Neuropsychopharmacology, 9/2S:164S (1993).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Effects of neurotoxic lesions in histaminergic neurons on behavior and brain cytokines. First Int. Congr. on Hormones, Brain and Neuropsychopharmacology, Rhodes, Sept. 13-17, 1993. Neuropsychopharmacology 9/2S:164S (1993).

Cacabelos, R. Presente y futuro de la investigación sobre la enfermedad de Alzheimer. III Congr. Soc. Gallega Gerontología y Geriatría, La Coruña, Sep. 23-25, 1993.

Cacabelos, R. Enfermedad de Alzheimer: Perspectivas para una década. Primeres Jornades Geriàtriques, Malatia d´Alzheimer, Universitat Ramon Llull, Barcelona, Oct. 22-23, 1993.

Cacabelos, R. Neurobiología y genética molecular de la enfermedad de Alzheimer. Simposium internacional: Perspectivas actuales de la genética humana. Fundación Ramón Areces, Madrid, Oct. 25-27, 1993.

Franco-Maside, A., Caamaño, J., Gómez, M.J., Álvarez, X.A., Fernández-Novoa, L., Novo, B., Cacabelos, R. CDP-choline-induced brain mapping changes in patients with Alzheimer’s disease. 6th Congr. ECNP, Budapest, Oct. l l-l4, 1993.

Caamaño, J., Franco, A., Gómez, M.J., Novo, B., Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Acute effects of CDP-choline on middle cerebral artery blood flow velocities in Alzheimer’s disease: A transcranial Doppler study. 6th Congr. ECNP, Budapest, Oct. 11-l4, 1993.

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Age-related changes in serum interleukin-1 and tumor necrosis factor-alpha levels in healthy control subjects. 6th Congr. ECNP, Budapest, Oct. 11-14, 1993.

Álvarez, X.A., Franco, A., Kamoun, A., Polo, E., Cacabelos, R., Rettori, M.C. S9977-2 reduces learning impairment and brain interleukin-1 overproduction in rats with neurotoxic lesions in the nucleus basalis of Meynert. 6th Congr. ECNP, Budapest, Oct. 11-14, 1993.

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Effects of Anapsos on behavior and brain neuroimmune function. 6th Congr. ECNP, Budapest, Oct. 11-14, 1993.

Cacabelos, R. Tratamento farmacologico da Doença de Alzheimer: Bases moleculares. Psiquiatría: das suas raices aos seus elos de ligaçao. Figueira da Foz, Oct. 28-30, 1993.

Cacabelos, R. Envejecimiento y demencia en el marco de la atención primaria. Simposium satélite Bayer. Congr. Soc. Esp. Med. Fam. Comunitaria. La Coruña, Nov. 11-13, 1993.

1992

Cacabelos, R. Psicofarmacología molecular de la enfermedad de Alzheimer, Nuevas estrategias terapéuticas. IV Congr. Intern. Farmacoterapia y Nutrición Geriátrica, Valencia, 26-29.2.92 (1992).

Cacabelos, R. Neurobiología molecular de la enfermedad de Alzheimer. Prospecciones terapéuticas. I Symposium de Psicobiología. Perspectivas Actuales de Investigación en Psicobiología. La Coruña, 9-13.3.92 (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. GRF-induced GH response in opiate addicts. Int. Meeting. Strategies for studying CNS active compounds: Models, screens and clinical syndromes. Madrid, 26 April-2 May, 1992. Behav. Pharmacol., 3(Suppl. 1):60 (1992).

Fernández-Novoa, L., Pastuzko, A., Franco, A., Álvarez, X.A., Cacabelos, R. Effects of neurocatin on the release and level of serotonin in synaptosomes from the rat brain. Int. Meeting. Strategies for studying CNS active compounds: Models, screens and clinical syndromes. Madrid, 26 April-2 May, 1992. Behav. Pharmacol., 3(Suppl. 1):94 (1992).

Fernández-Novoa, L., Pastuszko, A., Franco, A., Álvarez, X.A., Cacabelos, R. The effects of neurocatin on serotonin metabolism in synaptosomes from the rat brain. Int. Meeting. Strategies for studying CNS active compounds: Models, screens and clinical syndromes. Madrid, 26 April-2 May, 1992. Behav. Pharmacol., 3(Suppl. 1):94-95 (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Positive effects of GHRP-6 on passive avoidance behavior in a new experimental paradigm. Int. Meeting. Strategies for studying CNS active compounds: Models, screens and clinical syndromes. Madrid, 26 April-2 May, 1992. Behav. Pharmacol., 3(Suppl. 1):84-85 (1992).

Cacabelos, R., Fernández-Novoa, L., Franco-Maside, A., Álvarez, A. Neuroendocrine and neuroimmune modulatory effects of brain histamine: physiological responses and pathological implications in Alzheimer’s disease. XXI Ann. Meeting European Histamine Research Society. Torremolinos, Málaga, 13-17 May, 1992, pp. 90 (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Effects of betahistine on locomotor activity and passive avoidance behavior in rats. XXI Ann. Meeting European Histamine Research Society. Torremolinos, Málaga, l3-17 May, pp. 95 (1992).

Cacabelos, R. Función neuroinmune en trastornos mentales: papel de la histamina cerebral como neuroinmunomodulador en condiciones fisiológicas y patológicas. XII Congr. Asoc. Latinoamer. Soc. Biol. Med. Nuclear. Madrid, Mayo 25-28 (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Dose- and time-dependent effects of histamine on hypothalamic levels of interleukin-1 in rats. XXI Ann. Meeting European Histamine Research Society. Torremolinos, Málaga, 13-17 May, pp. 107 (1992).

Cacabelos, R. Hacia un tratamiento etiopatogénico de la enfermedad de Alzheimer: Psicofarmacología molecular. Mesa Redonda: Nuevas alternativas terapéuticas en la enfermedad de Alzheimer, III Congr. Nac. Soc. Esp. Psiquiat. Biol., Pamplona 17-20 Junio, pp. 63-64 (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Efectos positivos de la betahistina sobre el deterioro del aprendizaje inducido por escopolamina en ratas. III Congr. Nac. Soc. Esp. Psiquiat. Biol., Pamplona 17-20 Junio, pp. 259-260 (1992).

Franco, A., Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Efectos del tratamiento con citicolina sobre función cognitiva y niveles séricos de interleucina-1 en la demencia senil, III Congr. Nac. Soc. Esp. Psiquiat. Biol., Pamplona 17-20 Junio, pp. 260-261 (1992).

Caamaño, J., Valle-lnclán, F., Cacabelos, R. Velocidades de flujo sanguíneo en arteria cerebral media de pacientes con demencia vascular: evaluación mediante ultrasonografía Doppler transcraneal. III Congr. Nac. Soc. Esp. Psiquiat. Biol., Pamplona 17-20 Junio (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Age- and sex-related serum growth hormone (GH) levels in psychiatric patients and healthy control subjects. A correlation study between GH values and cognitive performance. Proc. 18th Collegium Internationale Neuro- Psychopharmacologicum Congress. Nice, June 28-July 2, 1992. Clin. Neuropharm., 15(Suppl. 1-B);283B (1992).

Cacabelos, R., Franco-Maside, A., Álvarez, X.A. Therapeutic effects of CDP-Choline on cognition and cardiovascular parameters in Alzheimer’s disease. Proc. 18th CINP Congress, Nice, June 28-July 2, 1992. Clin. Neuropharmacol., 15(Suppl. 1-B):474B (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Effects of betahistine on behavior in rats. Preliminary results. Proc. 18th CINP Congress, Nice, June 28-July 2, 1992. Clin. Neuropharmacol., 15(Suppl. 1-B) :478B (1992).

Fernández-Novoa, L., Pastuszko, A., Franco, A., Álvarez, X.A., Cacabelos, R. Inhibition of monoamine oxidase A by neurocatin in synaptosomes from rat brain. Proc. 18th CINP Congress, Nice, June 28-July 2, 1992. Clin. Neuropharmacol., 15(Suppl. 1-B):590B (1992).

Cacabelos, R., Álvarez, X.A., Franco-Maside, A., Fernández-Novoa, L., Caamaño, J., Valle-lnclán, F. Influence of CDP-Choline on cognition and interleukin-1 in Alzheimer’s disease (AD) and multi-infarct dementia (MID). The Third International Conference on Alzheimer’s Disease and Related Disorders. Padova, July 12-17, 1992. Neurobiol. Aging 13(Suppl. 1):S134-S135 (1992).

Cacabelos, R., Álvarez, X.A., Franco, A., Fernández-Novoa, L., Caamaño, J., Valle-lnclán, F., Secades, J., Novell, R., Lozano, R. Therapeutic effects of CDP-Choline in Alzheimer’s disease and multi-infarct dementia. International Conference on Neurodegenerative Disease. New Approaches to Treatment. London. 15-16 Sept., 1992.

Cacabelos, R., Álvarez, X.A., Franco, A., Fernández-Novoa, L., Caamaño, J., Valle-lnclán, F., Secades, J., Novell, R., Lozano, R. Effects of CDP-Choline in Alzheimer’s disease and multi-infarct dementia: Influence on cognition, mood, and interleukin- production. 8th lnt. Meeting and Conference. Alzheimer Disease International (ADI). Brussels, Sept. 25-27 (1992).

Cacabelos, R., Álvarez, X.A., Franco, A., Fernández-Novoa, L., Caamaño, J., Valle-lnclán, F., Secades, J., Novell, R., Lozano, R. Therapeutic effects of CDP-Choline in Alzheimer’s disease and multi-infarct dementia. Int. Conf. Neurodegenerative Disease. New Approaches to Treatment. London, Sept. 15-16 (1992).

Cacabelos, R. Basic mechanisms and classification of memory disorders with special reference to dementias. Workshop: Technical aids for memory and environmental control in dementia and other cognitive impairment. NORAGE ’92. First Congress of the Nordic Society for Research in Brain Aging. Sheraton Copenhagen Hotel, Copenhagen, Denmark, Oct. 9-10 (1992).

Cacabelos, R. Estrategias terapéuticas en la enfermedad de Alzheimer. Avances en la enfermedad de Alzheimer y relación de A.F.A.F. con las líneas de investigación en España. 1ª Reunión Asociación Familiares de Alzheimer de Andalucía y 1º Congreso de la Federación Española de Asociaciones de Familiares de enfermos de Alzheimer. Málaga, Oct. 1-2 (1992).

Valle-lnclán, F., Caamaño, J., Cacabelos, R. Functional relationship between blood-flow velocity in middle cerebral artery and EEG spectral analysis. Vth Congr. Eur. College Neuropsychopharmacology. Marbella, 18-21 Oct. 1992. Eur. Neuropsychopharmacol., 2/3:326 (1992).

Franco, A., Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Betahistine attenuates learning impairment induced by scopolamine in rats. Vth Congr. Eur. College Neuropsychopharmacology. Marbella, 18-21 Oct. 1992. Eur. Neuropsychopharmacol., 2/3:354 (1992).

Caamaño, J., Valle-lnclán, F., Cacabelos, R. Parieto-temporal hypoperfusion in Alzheimer’s disease measured by transcranial doppler ultrasonography. Vth Congr. Eur. College Neuropsychopharmacology. Marbella, 18-21 Oct. 1992. Eur. Neuropsychopharmacol., 2/3:360 (1992).

Fernández-Novoa, L., Pérez-Trullén, J.M., Cacabelos, R. Serum histamine in Alzheimer’s disease and multi-infarct dementia. Vth Congr. Eur. College Neuropsychopharmacology, Marbella 18- 21 Oct. 1992. Eur. Neuropsychopharmacol., 2/3:360 (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Central and peripheral interleukin-l in Alzheimer’s disease. Vth Congr. Eur. College Neuropsychopharmacology, Marbella 18- 21 Oct. 1992. Eur. Neuropsychopharmacol., 2/3:361-362 (1992).

Cacabelos, R., Álvarez, X.A., Franco-Maside, A., Fernández- Novoa, L., Caamaño, J., Valle-lnclán, F. Effect of CDP-Choline on cognition and immune function in Alzheimer’s disease and multi-infarct dementia. Vth Congr. Eur. College Neuropsychopharmacology, Marbella 18-21 Oct. 1992. Eur. Neuropsychopharmacol., 2/3:362-363 (1992).

Gómez, M.J., Álvarez, X.A., Cacabelos, R. Dementia Mood Assessment Scale in elderly controls and in patients with depression and/or cognitive impairment. 6th Eur. Congr. Assoc. Eur. Psychiat., Barcelona 3-7 Nov., 1992. Anales Psiquiatría 8(Supl. 1):102 (1992).

Álvarez, X.A., Franco, A., Fernández-Novoa, L., Cacabelos, R. Serum growth hormone (GH) levels in psychiatric patients. 6th Eur. Congr. Assoc. Eur. Psychiat., Barcelona 3-7 Nov., 1992. Anales Psiquiatría, 8(Supl.1)106 (1992).

Caamaño, J., Valle-lnclán, F., Cacabelos, R. Blood flow velocity in multi-infarct dementia and Alzheimer’s disease: Neuropsychological correlations. 6th Eur. Congr. Assoc. Eur. Psychiat., Barcelona 3-7 Nov., 1992. Anales Psiquiatría, 8(Supl.1):107-108 (1992).

Cacabelos, R., Álvarez, X.A., Franco, A., Gómez, M.J., Fernández-Novoa, L., Caamaño, J., Valle-lnclán, F. Influence of CDP-Choline on cognitive parameters in Alzheimer’s disease and multi-infarct dementia. 6th Eur. Congr. Assoc. Eur. Psychiat., Barcelona 3-7 Nov., 1992. Anales Psiquiatría, 8(Supl.1):108 (1992).

Cacabelos, R., Fernández-Novoa, L., Franco, A., Álvarez, X.A. Serum histamine and tumor necrosis factor (TNF) in Alzheimer’s disease and multi-infarct dementia. 6th Eur. Congr. Assoc. Eur. Psychiat., Barcelona 3-7 Nov. 1992. Anales Psiquiatría, 8(Supl.1):108 (1992).

Franco, A., Álvarez, X.A., Fernández-Novoa, L., Cacabelos, R. Serum interleukin-1p in control subjects and senile dementia. 6th Eur. Congr. Assoc. Eur. Psychiat., Barcelona 3-7 Nov. 1992. Anales Psiquiatría, 8(Supl.1):109 (1992).

1991

Franco, A., Álvarez, X.A., Mallo, F., Díaz, E., Cacabelos, R. Deterioro del aprendizaje por evitación pasiva en ratas con dieta deficiente en ácido retinoico. X Congr. Nac. Soc. Esp Endocrinología. Santiago de Compostela, 5-7 Junio, 1991. Endocrinología, 38(Supl.2):39 (1991).

Álvarez, X., Franco, A., Mallo, F., Díaz, E., Cacabelos, R. Efecto del hexapéptido liberador de hormona de crecimiento (GHRP-6) sobre conducta en ratas. X Congr. Nac. Soc. Esp. Endocrinología. Santiago de Compostela, 5-7 Junio, 1991. Endocrinología, 38(Supl.2);44-45 (1991).

Franco-Maside, A., Álvarez, X.A., Cacabelos, R. Atrial natriuretic peptide in Alzheimer’s disease. 5th World Congr. Biol. Psychiatry, Florence, Italy, June 9-14, 1991. Biol. Psychiatry 29/11S:479S-480S (1991).

Álvarez, X.A., Franco-Maside, A., Cacabelos, R. GRF-induced GH response in Alzheimer’s disease (AD), multi-infarct dementia (MID), and pseudodementia (PD). 5th World Congr. Biol. Psychiatry, Florence, Italy, June 9-14, 1991. Biol. Psychiatry, 29/l l S:685S (1991).

Cacabelos, R., Franco-Maside, A., Álvarez, X.A. Interleukin-l (IL-1) in Alzheimer’s disease (AD). 5th World Congr. Biol, Psychiatry, Florence, Italy, June 9-14, 1991. Biol. Psychiatry, 29/11S:687S (1991).

Cacabelos, R., Barquero, M., García, P., Álvarez, X.A., Varela de Seijas, E. Cerebrospinal fluid interleukin 1 in Alzheimer’s disease. XXII Congr. Intern. Soc. Psychoneuroendocrinology, Siena, Italy, June 17-20, 1991. Neuroendocr. Lett., 13 :206 (1991).

Franco, A., Álvarez, X.A., Cacabelos, R. Acute effects of growth hormone releasing factor (GRF) on cognitive function in aging and senile dementia. XXII Congr. intern. Soc. Psychoneuroendocrinology, Siena, Italy, June 17-20, 1991. Neuroendocr. Lett., 13:213 (1991).

Álvarez, X.A., Vara, E., Barquero, M., García, P., Moreno, A., Varela de Seijas, E., Cacabelos, R. Cerebrospinal fluid (CSF) insulin in Alzheimer’s disease. XXII Congr. Intern. Soc. Psychoneuroendocrinology. Siena, Italy, June 17-20, 1991. Neuroendocr. Lett., 13:249 (1991).

Álvarez, X.A., Franco, A., Fernández, L., Caso, J., Cacabelos, R. Interleukin-l in senile dementia. Correlation with physiological and cognitive parameters. Il Eur. Congr. Gerontol., Madrid 11-14 Sept., 1991. Rev. Esp. Geriat. Gerontol., 26 (Supl.1):202 (1991).

Franco, A., Álvarez, X.A., Caso, J., Fernández, L., Cacabelos, R. Atrial natriuretic peptide in senile dementia. Il Eur. Congr. Gerontol., Madrid 11-14 Sept., 1991. Rev. Esp. Geriat. Gerontol., 26 (Supl. 1):202 (1991).

Álvarez, X.A., Franco, A., Caso, J., Fernández, L., Cacabelos, R. GRF-induced GH response in senile dementia. Correlation between neurophysiological and neuroendocrine parameters. II Eur. Congr. Gerontol., Madrid 11-l4 Sept., 1991. Rev. Esp. Geriat. Gerontol., 26 (Supl. l):203 (l99l).

Cacabelos, R. Brain histamine: Neuroendocrine regulator in physiological and pathological conditions. Symposium Biogenic Amines. 1st Int. Cong. Vitamins and Biofactors in Life Sciences (ICVB): Kobe, Japan, Sept. 16-20; pp. 53 (1991).

Cacabelos, R., Álvarez, X.A. Environmental factors, development and cognition: Influence of the somatotropinergic system (STS) on mental function and psychomotor activity. VIth Int. Congr. Auxology. Madrid, 15-19 Sept. (1991).

Pérez-Trullén, J.M., Vázquez-André, M.L., Álvarez, X.A., Cacabelos, R. La onda P300 como método diagnóstico en la enfermedad de Alzheimer. IV Congr. Soc. Esp. Neurociencia. Alicante 30.9-3.10, 25.16-P (1991).

Álvarez, X.A., Franco, A., Mallo, F., Díaz, E., Cacabelos, R. El tratamiento con testosterona revierte el deterioro del aprendizaje inducido por déficit de ácido retinoico en ratas. IV Cong. Soc. Esp. Neurociencia, Alicante 30.9-3.10, 32-16-P (1991).

Álvarez, X.A., Franco, A., Cacabelos, R. Efectos del GRF(1- 29)NH2 sobre función cognitiva en la demencia senil. IV Cong. Soc. Esp. Neurociencia, Alicante 30.9-3.10, 32-17P (1991).

Cacabelos, R. Marcadores genéticos en Psiquiatría. XVI Reun. Nac. Soc. Esp. Psiquiatría Biológica, Vitoria, 7-9 Nov., (1991).

Franco, A., Álvarez, X.A., Gómez-Trigo, J., Caamaño, J., Cacabelos, R. Influencia del GRF sobre función mental en la demencia senil. XVI Reun. Nac. Soc. Esp. Psiquiat. Biol., Vitoria, 7-9 Nov., 1991. Anales Psiquiatría, 7: 111 (1991).

Álvarez, X.A., Franco, A., Gómez-Trigo, J., Caamaño, J., Cacabelos, R. Interleucina-1 central y periférica en la demencia senil. XVI Reun. Nac. Soc. Esp. Psiquiat. Biol., Vitoria, 7-9 Nov., 1991. Anales Psiquiatría, 7: 111 (1991).

Álvarez, X.A., Franco, A., Gómez-Trigo, J., Caamaño, J., Vara, E., Barquero, M., García, P., Moreno, A., Varela de Seijas, E., Cacabelos, R. Insulina central en la demencia senil. XVI Reun. Nac. Soc. Esp. Psiquiat. Biol., Vitoria, 7-9 Nov., 1991. Anales Psiquiatría, 7: 112 (1991).

Pérez-Trullén, J.M., Vázquez André, M.L., Cacabelos, R. Estudio de la prosodia en la enfermedad de Alzheimer. XVI Reun. Nac. Soc. Esp. Psiquiat. Biol., Vitoria, 7-9 Nov., 1991. Anales Psiquiatría, 7: 113 (1991).

Pérez-Trullén, J.M., Vázquez André, M.L., Caso, J., Álvarez, X.A., Franco, A., Cacabelos, R. Alteraciones del lenguaje en la enfermedad de Alzheimer. XV1 Reun. Nac. Soc. Esp. Psiquiat. Biol., Vitoria, 7-9 Nov., 1991. Anales Psiquiatría, 7: l l3 (1991).

Pérez-Trullén, J.M., Vázquez-André, M.L., Modrego, A., Álvarez, X.A., Cacabelos, R. Trastornos de memoria y P300 en la enfermedad de Alzheimer. XVI Reun. Nac. Soc. Esp. Psiquiat. Biol., Vitoria, 7-9 Nov., 1991. Anales Psiquiatría, 7: 114 (1991),

Cacabelos, R. Nuevos aspectos de la etiopatogenia de la enfermedad de Alzheimer. Workshop internacional. Envejecimiento y Farmacología Preventiva. Alicante, 13-14 Dic., (1991).

Cursos y Seminarios

2011

El mercado alternativo bursátil. ¿Por qué una PYME sale a Bolsa? Hotel InterContinental, Madrid, 31 Marzo, 2011.

Nuevas perspectivas en medicina genómica en el entorno laboral. VI Seminario sobre Medicina del Trabajo. Auditorio Garrigues, Madrid, 26 Octubre, 2011.

2010

Impacto social de la genómica y medicina personalizada. Dirección General de la Policía y de la Guardia Civil. Cuerpo Nacional de Policía. División de Formación y Perfeccionamiento. Jefatura Superior de Policía de Galicia. Salón de Actos de la Fundación Caixa Galicia, Coruña, 20 Abril, 2010.

Medicina Genómica y personalización del tratamiento farmacológico. Fedefarma. Federació Farmacéutica. Aula de Formación de Massanassa, Valencia, 3 Junio, 2010.

2009

Biotecnología de la salud. Presentación de la Ciudad Agroalimentaria de Tudela, Madrid, Marzo 24 (2009).

Biotecnología aplicada a la nutrición humana en la industria de conservación de productos de la pesca y la acuicultura. Jornada Anfaco-Cecopesca. Vigo, 24 Junio (2009).

2008

Actividad física y nutrición en atención primaria. Agencia Laín Entralgo, Comunidad de Madrid, Universidad Camilo José Cela. 30 Junio-3 Julio (2008).

La innovación científica como motor de desarrollo en España y Japón. XI Foro España-Japón. Fundación Consejo España-Japón, Ministerio de Asuntos Exteriores y de Cooperación, Gobierno de España, Xunta de Galicia. Hostal Reyes Católicos, 3-4 Oct (2008).

Cacabelos, R. Aplicación de la farmacogenética para optimizar recursos terapéuticos.
Ciclo “Novedades en Investigación Biomédica”. Hospital Virgen del Rocío, Sevilla, 13 Dic., 2008.

2007

Farmacogenómica en la enfermedad de Alzheimer. Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, México. 29 Nov (2007).

Medicina Genómica. Universidad Autónoma de Guadalajara. Dirección de Comunicación Universitaria, Guadalajara, México. 30 Nov (2007).

2006

La Salud del Directivo: Riesgos y Prevención. Asociación Española de Directivos (AED). Salón de Actos de UNESA, Madrid. 14 Marzo 2006.

Máster en Gerontología Social. 5ª Edición Iberoamericana, La Serena, Chile, 2005-2006. Directora: Rocío Fernández-Ballesteros.
Biología del Envejecimiento (6 horas)
Neurobiología del Envejecimiento Patológico (4 horas).

Medicina Genómica. Curso “Últimas tendencias en el diseño de drogas y vacunas antiparasitarias”. Centro de Cálculo Científico, Universidad de los Andes, Mérida, Venezuela. 5-9 Junio, 2006.

Enfermedades Neurológicas: Presente y Futuro. Asociación Galega de Estudio e Opinión (AGEO). Hostal Reyes Católicos, Santiago de Compostela. 16 Junio (2006).

Medicina Genómica y enfermedades degenerativas. Cursos de Verano 2006 Universidad Complutense. Terapia Génica (Director: Antonio Liras). Real Fundación Victoria Eugenia, El Escorial. 3-7 Julio (2006).

La Medicina Genómica del Futuro. Conferencias de ENCIGA (Asociación dos Ensinantes de Ciencias de Galicia). Aula Magna da Facultade de Matemáticas de Santiago de Compostela. (27.10.2006).

2005

Functional Genomics and Pharmacogenomics of Alzheimer’s Disease. Karolinska Institutet, Huddinge, Stockholm. June 8, 2005.

Medicina Genómica: Los grandes retos del futuro. Plan Español de Prevención de Riesgos Cerebrales y Medicina Genómica. Sociedad Española de Medicina Genómica. Murcia. 28 Abril, 2005.

Oportunidades y desafíos de la medicina individualizada y predictiva. Jornada Biotecnología y Salud. Retos y Desafíos para la Empresa Española. Madrid. 24 Mayo, 2005.

Curso de Medicina Genómica para Especialistas en Medicina del Trabajo. Dirección: Ramón Cacabelos y Javier Sanz. Escuela Nacional de Medicina del Trabajo, Universidad Complutense, Madrid. 23 Junio, 2005.

Medicina Genómica y Libertad del Individuo. Club Ramazzini, Casino, Madrid. 23 Junio, 2005.

Medicina Genómica: Retos del Futuro. Soria Saludable. Fundación Caja Rural, Soria. 3 Nov. 2005.

2004

Bases Biológicas: Neurobiología del envejecimiento cerebral. Máster en Gerontología Social. Especialidad en Calidad de Servicios Gerontológico. Dirección: R. Fernández-Ballesteros. Facultad de Psicología. Universidad Autónoma de Madrid. Madrid. enero-diciembre 2004.

Genomic Medicine: Implications for Diagnosis and Treatment. Brno Faculty Hospital. Center of Molecular Biology and Gene Therapy, Brno, Czech Republic. 3 May, 2004.

Pharmacogenetics in Complex Disorders. Institute of Haematology and Blood Transfusion. Charles University General Hospital, Prague, Czech Republic. 4 May, 2004.

Estrategias terapéuticas en farmacogenómica y productos nutracéuticos. Programa de Formación Continuada. Federació Farmacéutica S. Coop. C.L. Valencia. Mayo, 2004.

2003

Estado actual en el conocimiento de las demencias: Pasado y Futuro. Aspectos psicológicos y sociosanitarios de las demencias: Retos para el futuro. Cursos de Extensión Universitaria. Universidad de Oviedo. (10-14.2.2003).

La enfermedad de Alzheimer en la actualidad. Cursos de verano de la Universidad de Cantabria. IV Cursos de Verano de Santander. La Sociedad ante la enfermedad de Alzheimer: Retos para el futuro. Santander. (7-11 Julio, 2003).

La enfermedad de Alzheimer y otras demencias: claves en el diagnóstico diferencial. Cursos de verano de la Universidad de Cantabria. IV Cursos de Verano de Santander. La Sociedad ante la enfermedad de Alzheimer: Retos para el futuro. Santander. 7-11 Julio, 2003.

2002

Hacia un tratamiento etiopatogénico de la enfermedad de Alzheimer. Centro de Investigación Ferrer, Barcelona. (20.2.2002).

Bases biológicas de la vejez: Neurobiología del envejecimiento cerebral. Curso de especialista en gerontología social. Universidad Autónoma de Madrid, Facultad de Psicologia, y Ministerio de Trabajo y Asuntos Sociales. Madrid. 2002.

Biotecnología para la salud humana y animal. Reunión Expertos. ASEBIO. Madrid. (5.12.2002).

Máster en Gerontología Social. 4ª Edición Iberoamericana, San Luís Potosí, México, 2002-2003. Ministerio de Trabajo y Asuntos Sociales/IMSERSO; Facultad de Psicología, Universidad Autónoma de Madrid; Secretaría de Desarrollo Social (SEDESOL); Instituto Nacional de las Personas Adultas Mayores (INAPAM), México.
-Biología del Envejecimiento (6 Horas)
-Neurobiología del Envejecimiento Patológico (4 Horas).

2001

Bases biológicas de la vejez. Máster en Gerontología Social. Universidad Autónoma de Madrid. 2001.

Neurobiología del Envejecimiento Patológico. Máster en Gerontología Social. Universidad Autónoma de Madrid. 2001.

Las enfermedades neurológicas en la edad adulta. Necesidades, cuidados y recursos actuales y futuros. Envejecimiento y discapacidad: El reto sociosanitario. II Máster Universitario en Dirección y Gestión de Programas y Centros Gerontológico Socio-Sanitarios. Universidad de Vigo y Ministerio de Trabajo y Asuntos Sociales. 2001.

Farmacogenómica de la enfermedad de Alzheimer. Conferencia X Aniversario EuroEspes. Centro de Investigación Biomédica EuroEspes, Bergondo, La Coruña. (19.4.2001).

Vacas tolas e medios de comunicación. Concello de Porriño, Concellería de Cultura, Porriño, Pontevedra. (25.4.2001).

Enfermedades priónicas en el ganado bovino y ovino. Diagnóstico en vida del animal. Certificación genética de una ganadería. Asociación Mutual Aseguradora (AMA), Madrid. (8.5.2001).

La enfermedad de Alzheimer en la actualidad: desafíos más importantes. 61º Cursos de Verano de Extensión Universitaria. Avances en la enfermedad de Alzheimer (Cod. 1680.61). Universidad de Oviedo, Gijón. (2-6.7.2001).

Investigación actual y perspectivas de tratamiento de la enfermedad de Alzheimer. 61º Cursos de Verano de Extensión Universitaria. Avances en la enfermedad de Alzheimer (Cod. 1680.61). Universidad de Oviedo, Gijón. (2-6.7.2001).

Identificación del riesgo genético y farmacogenómica de la enfermedad de Alzheimer. Avances y calidad de vida en la enfermedad de Alzheimer. AFA Tenerife, Tenerife. (4-5.10.2001).

Un centro multidisiciplinar de iniciativa privada. II Jornadas Técnicas ASEM Galicia. Capacidade 2001. Instituto Ferial de Vigo. (2-4.11.2001).

2000

Protocolo diagnóstico y terapéutico de pacientes de proyecto ADI. I Curso de Orientadores y IV de Profesores ADI. Centro Médico EuroEspes, Bergondo, La Coruña. (23.2.2000).

Bases biológicas de la vejez. Envejecimiento normal. Máster de Gerontología Social. Especialidad en Calidad de Servicios Gerontológico. Facultad de Psicología. Universidad Autónoma de Madrid. (17.3.2000).

Neurobiología del envejecimiento humano patológico. Máster de Gerontología Social. Especialidad en Calidad de Servicios Gerontológico. Facultad de Psicología. Universidad Autónoma de Madrid. (17.3.2000).

Salud Mental y Bienestar Personal. Bases biológicas de los procesos neurodegenerativos. Vacaciones Inteligentes 2000. Lanzarote. (21-23.7.2000).

Malatia d’Alzheimer: Etioaptogènia, genética i farmacogenòmica. Conferencia de Cloenda. Hospital Universitari del Mar, Sessions Clíniques, Barcelona. (25.5.2000).

Investigación básica y clínica en la enfermedad de Alzheimer. Cursos de Verano de Extensión Universitaria. Universidad de Oviedo. Avances en la enfermedad de Alzheimer. Cátedra Jovellanos de Extensión Universitaria, Gijón. (4.7.2000).

Trastornos neuropsiquiátricos en la enfermedad de Alzheimer. Cursos de Verano de Extensión Universitaria. Universidad de Oviedo. Avances en la enfermedad de Alzheimer. Cátedra Jovellanos de Extensión Universitaria, Gijón. (4.7.2000).

Muerte cerebral y eutanasia. Universidad de Verano SEK. ¿Hay vida después de la vida? La respuesta de la ciencia y el pensamiento de vanguardia. Universidad SEK, Segovia. (3-5.7.2000).

Enfermedad de Alzheimer. Causas y futuro terapéutico. Universidad Islas Baleares. Palma de Mallorca. (15.9.2000).

Programa de intervención en demencias. Universidad Islas Baleares, Palma de Mallorca. (16.9.2000).

Estrategias terapéuticas en la enfermedad de Alzheimer. Hacia un tratamiento integral. Hotel Bogotá Royal, Bogotá, Colombia. (28.6.2000).

1999

Bases neurobiológicas del envejecimiento normal y patológico. Programa Doctorado: Cognición y trastornos. Curso: Déficits intelectuales y envejecimiento. Coordinadora: Prof. Dra. Rocío Fernández-Ballesteros. Universidad Autónoma de Madrid. (12.2.1999).

Bases biológicas de la vejez: Neurobiología del envejecimiento cerebral. Curso de Especialista en Gerontología Social. Dirección: Prof. Dra. Rocío Fernández-Ballesteros. Universidad Autónoma de Madrid. (12.2.1999).

Aspectos biosociales de la enfermedad de Alzheimer. Primeras Jornadas de Gerontología Social. Monográfico sobre la enfermedad de Alzheimer. Aula Magna Facultad de Psicología, Universidad de Granada, Granada. (27.2.1999).

Daño cerebral degenerativo e isquémico: Estrategia diagnóstica, terapéutica y preventiva. Complejo Riviera, Montevideo. Instituto Nacional de Neurología, Facultad de Medicina, Montevideo, Uruguay. (14.6.1999).

Daño cerebral degenerativo e isquémico: Estrategia diagnóstica, terapéutica y preventiva. Hotel Aconcagua, Mendoza. Cátedra de Clínica neurológica, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina. (15.6.1999).

Daño cerebral degenerativo e isquémico: Estrategia diagnóstica, terapéutica y preventiva. Colegio Médico de Corrientes. Sociedad de Psiquiatría de Corrientes, Colegio de Neuropsicofarmacología del Nordeste, Sociedad de Neurología y Neurocirugía de Chaco, Corrientes, Argentina. (16.6.1999).

Daño cerebral degenerativo e isquémico: Estrategia diagnóstica, terapéutica y preventiva. Hotel Metropol, Tucumán. Sociedad de Neurología de Tucumán, Sociedad de Gerontología y Geriatría de Tucumán, Sociedad de Psiquiatría de Tucumán, Tercer Curso de Actualización en Geriatría y Gerontología, Tucumán, Argentina. (17.6.1999).

Genética de la enfermedad de Alzheimer: Eventos etiopatogénicos y factores de riesgo primario. Círculo Médico de Rosario. Sociedad de Neurología y Neurocirugía de Rosario. Programa de Educación Continua, Ciclo 1999-2000. Rosario, Argentina. (18.6.1999).

Estrategias terapéuticas en la enfermedad de Alzheimer. Círculo Médico de Rosario, Sociedad de Neurología y Neurocirugía de Rosario. Programa de Educación Continua, Ciclo 1999-2000. Rosario, Argentina. (18.6.1999).

La enfermedad de Alzheimer en la actualidad: Evolución y clínica. Cursos de Verano. Extensión Universitaria. Universidad de Oviedo. La sociedad ante la enfermedad de Alzheimer: retos para el futuro. Cátedra Jovellanos, Gijón. (6.7.1999).

Enfermedades Neurodegenerativas y Envejecimiento. Conferencias de Divulgación Científica. Centro Cultural Caja Burgos. Aranda de Duero. (16.11.1999).

Enfermedad de Alzheimer. Causas, identificación de riesgos y soluciones asistenciales. Caja Duero, Béjar. (26.10.1999).

Nuevas aportaciones en la etiopatogenia de la enfermedad de Alzheimer. I Curso de Geriatría y Gerontología en Atención Primaria. Facultad de Medicina, Universidad de Valladolid. (10.12.1999).

Bases neurobiológicas del envejecimiento patológico. Máster en Gerontología Social. 3ª Edición Iberoamericana. Brasilia, Brasil. (Oct. 1999).

1998

Enfermedad de Alzheimer: Nuevos horizontes y apoyo sociosanitario. Asociación de familiares de enfermos de Alzheimer de la Ribera. Aranda de Duero, Burgos. (30.3.1998).

Abordaje terapéutico de la enfermedad de Alzheimer. Simposio internacional de la enfermedad de Alzheimer. México DF. (28.2.1998).

Abordaje terapéutico de la enfermedad de Alzheimer. Guadalajara, México. (2.3.1998).

Abordaje terapéutico de la enfermedad de Alzheimer. Tijuana, México. (4.3.1998).

Abordaje terapéutico de la enfermedad de Alzheimer. Monterrey, México. (6.3.1998).

La enfermedad de Alzheimer hoy. Mes de la salud. Fundación Caja Rural. Zamora. (11.5.1998).

Envejecimiento cerebral en una sociedad de mayores. Universidad de Verano Casado del Alisal. Palencia. (6.7.1998).

La enfermedad de Alzheimer en la actualidad: retos para el futuro. Cursos de Verano/Extensión universitaria. Universidad de Oviedo. Cátedra Jovellanos, Gijón. (9.7.1998).

Modelo integral en el tratamiento de la enfermedad de Alzheimer. Cursos verano. Cátedra Jovellanos, Gijón. (9.9.1998).

Necesidades actuales y planteamiento de futuro en la enfermedad de Alzheimer. Cursos verano. Cátedra Jovellanos, Gijón. (9.7.1998).

Bioética asistencial del anciano con enfermedad degenerativa. Prevención genética de la demencia. VI Jornadas Nacionales de Bioética. Granada. (25-26.9.1998).

La enfermedad de Alzheimer en la actualidad: retos para el futuro. Foro Gerontológico Asturiano. Oviedo. (8. 10. 1998).

Avances en el tratamiento integral de la enfermedad de Alzheimer. II Simposio Internacional de la enfermedad de Alzheimer. México DF, México. (20. l0.1998).

Avances en el tratamiento integral de la enfermedad de Alzheimer. Guadalajara, México. (21.10. 1998).

Avances en el tratamiento integral de la enfermedad de Alzheimer. Monterrey. México. (22.10.1998).

Actualidad científica en genética, biología molecular e impacto social de las neurociencias: Avances científicos. Gersalud, Cuenca. Cuenca. (6.11.1998).

Enfermedades neurodegenerativas y envejecimiento. Reto científico y sociosanitario en economías avanzadas. VII Ciclo de conferencias de divulgación científíca. Caja de Burgos, Burgos. (17.11.1998).

Enfermedad de Alzheimer y trastornos relacionados. Rosario, Argentina. (3.6.1998).

Los últimos avances médicos sobre la enfermedad de Alzheimer. Tercer Encuentro Internacional Alzheimer Monterrey ´98. Hospital San José, Monterrey, México. (24.10.1998).

Etiopatogenia de la enfermedad de Alzheimer. Curso de Psiquiatría Geriátrica. Instituto de Ciencias Médicas. Universidad de Valladolid. Facultad de Medicina. Director: J.A. Macías. (16.12.1998).

Diagnóstico de la enfermedad de Alzheimer. Curso de Psiquiatría Geriátrica. Instituto de Ciencias Médicas. Universidad de Valladolid. Facultad de Medicina. Director: J.A. Macías. (16.12.1998).

1997

Planes de prevención futura y apoyo psicosanitario de la enfermedad de Alzheimer. Caja de Ahorros de Salamanca y Soria. Asociación de Familiares de Alzheimer, Salamanca. (17.3.1997).

Alzheimer, el gran problema sociosanitario para la España del 2000. Ciclo “La Sanidad Española ante el reto del siglo XXI”. Badajoz. (11.3.1997).

Síntomas no cognitivos en las demencias. I Curso de Actualización en Psiquiatría y Salud Mental. Servicios de Salud Mental. Principado de Asturias. (5.3.1997).

Investigación de productos naturales aplicada al desarrollo de nuevos medicamentos. CIBE. Fundación EuroEspes, La Coruña. (10.3.1997).

Enfermedad de Alzheimer. AFAIC. Fundación y Presentación de la Asociación de Familiares de Enfermos de Alzheimer de Inca y Comarca. Inca, Baleares. (3.2.1997).

Aspectos sanitarios de la vida: Envejecimiento. Palacio de Congresos y Exposiciones de Melilla. Ministerio de Trabajo y Asuntos Sociales. V Centenario de Melilla. Jornadas: La vida a partir de los sesenta. (22.4.1997).

Retos de la juventud en el siglo XXI. Colegio de Fomento Peñarredonda. Palacio de Congresos. La Coruña. (10.5.1997).

Máster Universitario en Gerontología Social. Universidad de Granada e INSERSO/Ministerio de Trabajo y Asuntos Sociales. Módulo 6.6. Neurogerontología. (9.5.1997).

La enfermedad de Alzheimer: progreso científico y asistencia sociosanitaria. Semana de las personas mayores de la región de Murcia. Caja Murcia y Universidad de Murcia. (13.5.1997).

Deterioro cognitivo en el anciano. Claves diagnósticas y terapéuticas. Curso de Formación en Asistencia Geriátrica para Médicos de Atención Primaria y Médicos Residentes. Servicio de Medicina Interna. Hospital Clínico Universitario Virgen de la Victoria, Málaga. (3.6.1997).

El Alzheimer. Causas, tratamiento y prevención. Casino de Las Palmas. Hotel Sta. Catalina. Rotary Club. Las Palmas. (17.6.1997).

Avances científicos y asistencia sociosanitaria en la enfermedad de Alzheimer. II Jornadas sobre la enfermedad de Alzheimer. Asociación de Familiares de Enfermos de Alzheimer de Tenerife. (17-18.6.1997).

Seminario. Enfermedades de impacto social. Patologías degenerativas y demencia senil. Enfermedad de Alzheimer. UIMP. Santander. (30.6.1997).

Seminario. Enfermedades de impacto social. Patologías degenerativas y demencia senil. Trastonios psiquiátricos de la vejez. UIMP. Santander. (3.7.1997).

Seminario. Enfermedades de impacto social. Patologías degenerativas y demencia senil. Planes de prevención genética en enfermedades del sistema nervioso. UIMP. Santander. (4.7.1997).

Cerebrolysin: Basic and Clinical Studies in CNS Disorders. CIBE. Fundación EuroEspes, La Coruña. (9.7.1997).

Estado actual de la enfermedad de Alzheimer. Cursos de Verano. Universidad de Oviedo. Cátedra Jovellanos. Gijón. Julio 1997.

Porvenir asistencial y tratamiento de la enfermedad de Alzheimer. Retos en el año 2000. Cursos de Verano. Universidad de Oviedo. Cátedra Jovellanos. Gijón. Julio 1997.

Proyecto ESTREIA. Grupo de Trabajo: Enfoque y compromiso del sistema financiero gallego respecto a la innovación empresarial. Panel de Experiencias Empresariales de Financiación de la Innovación. Confederación de Empresarios de Galicia. Santiago de Compostela. (8.7.1997).

Curso de Doctorado. Universidad de Santiago de Compostela y Colegio Oficial de Médicos de La Coruña. Envejecimiento cerebral. Programa: Avances en fisiopatología y terapéutica médica como base de la investigación médica. Curso 96-97.

Enfermedad de Alzheimer: Planificación sociosanitaria e intervención terapéutica. Asociación de Familiares de Enfermos de Alzheimer (AFABUR): Burgos. (15.9.1997).

Tratamiento y prevención de la enfermedad de Alzheimer. Asociación de familiares de enfermos de Alzheimer. Soria. (16.9.1997).

Patología urológica en geriatría y trastornos del sistema nervioso central. CIBE. Fundación EuroEspes, La Coruña. (25.9.1997).

Actualización en enfermedad de Alzheimer. Etiopatogenia y diagnóstico. Parador Nacional de la Arruzafa. Córdoba. (20.9.1997).

Las prioridades de formación médica a nivel de gerentes de hospitales. Foro internacional. La educación médica de postgrado: Hacia la mejora de la calidad y los costes sanitarios. Colegio de Médicos. Madrid. (12.12.1997).

Enfermedades degenerativas. Curso de Psicogerontología. Universidad Autónoma de Madrid. Facultad de Psicología. Madrid. (11.12.1997).

Bases biológicas de la vejez: Neurobiología del envejecimiento cerebral. Curso de especialista en gerontología social. Universidad Autónoma de Madrid, Facultad de Psicologia, y Ministerio de Trabajo y Asuntos Sociales. Madrid. (12.12.1997).

Curso Máster Internacional a Distancia de Dirección de Institutos de Investigación. Escuela Internacional de Alta Dirección Hospitalaria, Madrid. (1997-1998).

Curso de Neurociencias. Escuela Internacional de Alta Dirección Hospitalaria. Madrid. (1997-1998).

Curso de Neuropsiquiatría en Atención Primaria. Escuela Internacional de Alta Dirección Hospitalaria. Madrid. (1997-1998).

Curso de Especialización en Neurogerontología y Neurogeriatría. Escuela Internacional de Alta Dirección Hospitalaria. Madrid. (1997-1998).

Curso de Especialización en Demencias y Enfermedad de Alzheimer. Escuela Internacional de Alta Dirección Hospitalaria. Madrid. (1997-1998).

1996

Sleep/Wake disorders in Alzheimer’s disease. S-20098/Phase IIb-Alzheimer’s disease. European Coordinators Meeting (2), IRIS, Paris. (3.1.1996).

Enfermedad de Alzheimer. Hacia un diagnóstico molecular y nuevas estrategias terapéuticas Programa Científico del I.M.Q. San Rafael, La Coruña. (30.1.1996).

Plan Español Anti-Demencia:
Presentación PEAD.
Etiopatogenia y marcadores diagnósticos de la demencia senil.
Protocolo diagnóstico en neurogeriatría.
Estrategias terapéuticas en la demencia.
Protocolo PEAD-Red Sanitaria Nacional.
I Reunión Plan Español Anti-Demencia, CIBE, La Coruña. (3.2.1996).

Estudios genéticos sobre la enfermedad de Alzheimer en la actualidad. Facultad de Psicología, Universidad de Granada. (16.2.1996).

Neurobiología del envejecimiento cerebral. Máster Universitario en Gerontología Social, Inserso. Universidad de Granada. (16.2.1996).

Estado actual de la enfermedad de Alzheimer. Club Prensa Asturiana, La Nueva España, Oviedo. (26.2.1996).

Tratamiento de las demencias. Diplomatura de salud mental. Facultad de Medicina, Oviedo. (26.2.1996).

Presentación Conferencia inaugural Club Última Hora. Enfermedad de Alzheimer. B. Winblad. Palma de Mallorca. (28.2.1996).

Demencia senil. Asociación Amas de Casa, La Coruña. (12.3.1996).

Enfermedad de Alzheimer: Planes de prevención e identificación genética en población de alto riesgo. Asociación de Familiares y Amigos Alzheimer-Zamora. (13.5.1996).

Avances en prevención de la enfermedad de Alzheimer. Curso de Cuidados a enfermos afectos de síndromes demenciales. Asociación Familiares de enfermos de Alzheimer. Andalucía, Málaga. Clínica Parque San Antonio, Universidad de Málaga, Málaga. (14.5.1996).

Sistema sociosanitario japonés y problemas relacionados con el envejecimiento poblacional. II Jornada Cultural Japonesa. Universidad de Alcalá de Henares, Madrid. (29.5.1996).

Alzheimer Hoy: Últimas novedades. Programa de Formación Permanente. Federación Farmacéutica, Valencia. (6.6.1996).

Doppler Sonography. Postgraduate Course on Alzheimer’s disease. The summer university of Southern Stockholm, Novum and Huddinge University Hospital, Karolinska Institutet, Stockholm. June 24-28, 1996.

Drug Trials. Postgraduate Course on Alzheimer’s disease. The summer university of Southern Stockholm. Novum and Huddinge University Hospital, Karolinska Institutet, Stockholm. June 24-28, 1996.

Tratamientos y causas de los trastornos mentales: Hacia nuevos conceptos de salud mental. Jornadas sobre la enfermedad mental, marginación y sufrimiento humano. Las Palmas de Gran Canaria. 18-22 Abril, 1996.

El Alzheimer, una enfermedad bien conocida. La enfermedad de Alzheimer en Castilla y León. Centro Hospitalario Benito Menni, Valladolid. 29.3.1996.

Biología del Envejecimiento (8 Horas):
Bases biológicas del envejecimiento.
Fisiología y Fisiopatología del envejecimiento.
Principios de neurogerontología.
Bases neurobiológicas de la memoria y del aprendizaje.
Patologías prevalentes.
Métodos de investigación.

Máster de Gerontología Social. 2ª Edición Iberoamericana. Santiago de Chile, Chile. 1996-1997 (7-11 Oct., 1996).

Programas Bio-Psico-Sociales en las Demencias (I) (2 Horas):
Demencia senil.

Máster en Gerontología Social. 2ª Edición Iberoamericana. Santiago de Chile, Chile. 1996-1997 (7-11 Oct., 1996).

Japón: Lecciones de una cultura en salud pública y bienestar social. INSERSO, Madrid. (5.11.1996).

Curso: Avances en demencia. Salud mental y psiquiatría en el umbral del nuevo milenio. I Reunión Regional Caribe y Países Bolivarianos “Carlos Alberto Seguín”. XIV Congreso Nacional de Psiquiatría “Honorio Delgado”. Lima. (28.11-1. 12.1996).

Doppler sonography in Alzheimer disease. Postgraduate Course in Alzheimer disease. Novum and Huddinge Hospital, Stockholm. (24-28.6.1996).

Drug trials in Alzheimer disease. Postgraduate Course in Alzheimer disease. Novum and Huddinge Hospital, Stockholm. (24-28.6.1996),

Enfermedad de Alzheimer. Factores etiopatogénicos y evaluación genética. Programa de Formación Permanente. Federación Farmacéutica. Valencia. Jun. 96.

Actualidad Científica y Sociosanitaria de la enfermedad de Alzheimer. Jornada Científica. Fundación Ramón Areces, Madrid. (10.6.1996).

Enfermedad de Alzheimer. Planes de prevención y apoyo sociosanitario. Asociación de Familiares de Alzheimer, La Coruña. (29.10.1996).

Bases biológicas de la vejez. Neurología del envejecimiento cerebral (3 horas). Especialista en Gerontología Social. Curso Académico 1996-97. Universidad Autónoma de Madrid, Madrid. Dic. 96.

1995

Retraso Mental y Neurodegeneración Cerebral. Fundación Ave María, Sitges, Saló d´Or. (16.1.1995).

Situación actual y perspectivas en el tratamiento de la enfermedad de Alzheimer. Liceo Recreo Orensano, Orense. (6.2.1995).

Enfermedad de Alzheimer. Perspectivas actuales de la medicina. Institut D´Estudis Ilerdencs. Diputació de Lleida, Lleida. (31.1.1995).

Neurogerontología del envejecimiento. Máster Universitario en Gerontología Social. Universidad de Granada, Ministerio de Asuntos Sociales, INSERSO, Granada. (10.2.1995).

Genética y función neuroinmune en la enfermedad de Alzheimer. Seminario. Neurociencias. Facultad de Medicina, Lleida. (31.2.1995).

Aspectos biológicos de la vejez. Envejecimiento y sistema nervioso central. Máster en Gerontología Social, Promoción 1994-1996. Facultad de Psicología, Universidad Autónoma, Ministerio de Asuntos Sociales, INSERSO, Madrid.

Avances recientes en la enfermedad de Alzheimer: Nuevas perspectivas y tratamiento. Universidad Internacional Menéndez Pelayo, Seminarios ´95. Actualidad Clínica en Geriatría, Sta. Cruz de Tenerife. (3-7.4.1995).

Demencia senil: Política sanitaria y residencial. Residencia Ballesol, Madrid. (25.4.1995).

Enfermedad de Alzheimer: Diagnóstico y terapéutica. Asociación de Familiares de Alzheimer, León. (3.5.1995).

Alzheimer’s disease: Genotyping and new treatments. Osaka University Medical School. Osaka, Japan. (22.5.1995).

Enfermedad de Alzheimer. Aula Tercera Edad, Ayuntamiento de Oviedo, Oviedo. (20.6.1995).

Demencia senil: Causas y asistencia sanitaria. Ayuntamiento de Bergondo, Bergondo, La Coruña. (3.6.1995).

Estado actual de la enfermedad de Alzheimer. Cursos de Verano. Necesidades Sociosanitarias del anciano: Debate y perspectivas de futuro. Universidad de Oviedo. Cátedra Jovellanos, Gijón. (3-7.7.1995).

Perspectivas de futuro y necesidades sociosanitarias en la enfermedad de Alzheimer. Cursos de Verano. Necesidades sociosanitarias del anciano: Debate y perspectivas de futuro. Universidad de Oviedo, Cátedra Jovellanos, Gijón. (3-7.7.1995).

Demencia senil: A epidemia do XXI. Demanda socio-sanitaria de coidados xeriátricos, do diagnóstico a atención integral. Universidade de Vigo. Cursos de Verán. Xeriatría: Problemática socio-sanitaria e servicios públicos. A integración coordinada dos recursos. Vigo. (11.7.1995).

Programas de identificación genética en la enfermedad de Alzheimer. Charla-Coloquio sobre Demencia tipo Alzheimer. Asociación Familiares Alzheimer. Salamanca. 2 Oct. 1995.

Demencias: Reseña diagnóstica y adelantos en el tratamiento. LATU, Montevideo. 13 Sept. 1995.

Novedades y últimos conceptos terapéuticos sobre citicolina. Vigencia actual en el tratamiento del envejecimiento cerebral, Alzheimer y ACV. Laboratorios Baliarda, Buenos Aires. 14 Sept. 1995

Bases neurológicas y neuroquímicas de la enfermedad de Alzheimer. II Jornadas sobre Demencia Senil Tipo Alzheimer. Asociación Alzheimer “Sta. Elena”. Sevilla. 20-22 Oct. 1995.

Enfermedad de Alzheimer. 7º Curso de Geriatría “Ciudad de San Sebastián”, San Sebastián. 16 Nov. 1995.

Enfermedad de Alzheimer. Clínica San Francisco, León. 20 Nov. 1995.

Preclinical and clinical strategies for the pharmacological evaluation of candidate drugs in Alzheimer’s disease. Janssen Pharmaceutica, Beerse, Belgium. 23 Nov. 1995.

Avances en genética y biología molecular en la esquizofrenia. Programa de Formación Especializada en Rehabilitación Psicosocial Integral en la Comunidad. Associació A.R.A.P.D.I.S., Barcelona. 24 Nov. 1995.

Problemática socio-familiar y tratamiento de la enfermedad de Alzheimer. Asociación Alzheimer-Canarias. Las Palmas de Gran Canaria. 30 Oct. 1995.

Tratamiento farmacológico de la demencia. Curso Trastornos psiquiátricos en la tercera edad. Instituto de Ciencias Médicas. Universidad de Valladolid, Valladolid. 12 Dic. 1995.

1994

Enfermedad de Alzheimer: Factores etiopatogénicos, criterios diagnósticos y normativa terapéutica. Programa de Formación Permanente. Federació Farmacéutica, Valencia. (13.1.1994).

Enfermedad de Alzheimer: Factores etiopatogénicos, criterios diagnósticos y normativa terapéutica. Programa de Formación Permanente. Departamento Técnico Federació Farmacéutica. Valencia. (13.1.1994).

Avances en la enfermedad de Alzheimer. Cursos de Verano 1994. Gijón. Psicogeriatría en la actualidad. Cátedra Jovellanos. Gijón. Julio 4-8, 1994.

Alteracions cognitivas ca idade: Demencia senil e doenza de Alzheimer. Cursos de Verán. Universidade de Vigo. Análise Xerontolóxico da realidade presente e o futuro das persoas maiores na comunidade. Vigo, Curso Nº 79. 11-12 Xullo, 1994.

Biología del envejecimiento. Máster Gerontología Social. PAMI-INSERSO. Buenos Aires, Argentina. Oct-Nov. 1994.

Alzheimer’s disease. Etiopathogenic factors and treatment. Russian Academy of Medical Sciences. National Mental Health Research Center. Moscow, Russia. 15 Oct. 1994.

Diagnosis of Alzheimer’s disease. Definition of AD genotype/phenotype. The Karolinska Institutet Postgraduate Education Series. Stockholm, Sweden. 19-20 Nov. 1994.

Etiopatogenia de la enfermedad de Alzheimer. Curso Doctorado. Univ. Zaragoza. Colegio Médicos. Zaragoza. 28 Nov. 1994.

Enfermedad de Alzheimer: Factores de Predicción Terapéutica. Presentación ANNALS OF PSYCHIATRY Vol. 4. Alzheimer’s Disease. Hotel Castellana-lntercontinental, Madrid. 20 Nov. 1994.

Genotipos de enfermedad de Alzheimer y estrategias terapéuticas. Presentación ANNALS OF PSYCHIATRY Vol. 4. Alzheimer’s Disease. Hotel Condes de Barcelona, Barcelona. 14 Dic. 1994.

Demencia senil: Responsabilidad médica y social. Cáritas Diocesana, Riveira, La Coruña. 17 Dic. 1994.

Psiconeuroendocrinología Experimental. Curso Doctorado, Facultad de Medicina, Universidad Complutense, Madrid. Curso 1994-1995.

1993

Enfermedad de Alzheimer: Perspectivas para una década. Hotel Majestic, Barcelona. (26.1.1993).

El proceso biológico del envejecimiento. Plan de Formación Bianual en Servicios Sociales. C.O.P.-INSERSO. Colegio Oficial de Psicólogos. Madrid. (26.2.1993).

Avances en el conocimiento de los síndromes demenciales. Estado actual de la terapéutica con vasorreguladores cerebrales. Curso de Postgrado. Avances en Psicofarmacología Aplicada. Directores: J. Bobes, M. Bousoño. Facultad de Medicina, Oviedo. (20.4.1993).

La demencia. Estado actual. Trastornos psiquiátricos en las demencias. Centre de Recerca Joan March. Universitat de les Illes Balears, Palma de Mallorca. (23.4.1993).

Nuevas aportaciones en la enfermedad de Alzheimer. I Curso Geriatría y Gerontología. Secretaría de Formación de Postgrado. Facultad de Medicina. Universidad de Valladolid. Valladolid. (4.6.1993).

La enfermedad de Alzheimer: El reto del futuro. La enfermedad de Alzheimer y otras demencias. INSERSO, Madrid. (23.6.1993).

Tratamiento de las demencias. Seminario de Actualización en Psicofarmacología. ARPYA, Valencia. (29.6.1993).

Neuroimmune function of brain histamine: Etiopathogenic and therapeutic implications in Alzheimer’s disease. Kursraum des Instituts für Pharmakologie und Toxikologie, Leopold- Franzens-Universitat Innsbruck, Austria. (23.11.1993).

1992

El futuro de la Psiquiatría Biológica. Gallery Hotel, Barcelona. (3.2.1992).

Neurotransmisores y envejecimiento. V Curso de Actualización Geriátrica. Facultad de Medicina. Universidad de Salamanca. Sociedad de Geriatría y Gerontología de Castilla y León. (22.2.1992).

Etiopatogenia de la enfermedad de Alzheimer: Prospecciones diagnósticas y terapéuticas. Colegio de Médicos de Barcelona. (19.3.1992).

Etiopatogenia y diagnóstico biológico de la enfermedad de Alzheimer. Curso: Enfermedad de Alzheimer y trastornos relacionados. Escuela Universitaria de Enfermería. Facultad de medicina. Universidad Complutense. Madrid. (22.4.1992).

Estrategia terapéutica en la enfermedad de Alzheimer. Curso: Enfermedad de Alzheimer y trastornos relacionados. Escuela Universitaria de Enfermería. Facultad de medicina. Universidad Complutense de Madrid. (22.4.1992).

Neuropatología molecular de la enfermedad de Alzheimer: Bases para un tratamiento etiopatogénico. Colegio de Médicos. La Coruña. (23.4.1992).

I Jornada de Formación Biomédica EuroEspes. Demencia Senil-I: Utilidad clínica de los antagonistas del calcio. Colegio de Médicos. Pontevedra. (28.5.1992).

II Jornada de Formación Biomédica EuroEspes. Demencia Senil- II: Tratamiento reparador de membrana neuronal. Colegio de Médicos. Valladolid. (12.6.1992).

Genética molecular y neuroquímica de la esquizofrenia. Facultad de Psicología. Universidad de Barcelona. (29.9.1992).

Implicación de los radicales libres en diversas patologías. Critical Care Forum. Radicales libres y patologías humanas. Hotel Torrequebrada. Benalmádena, Málaga. (10.11.1992).

Aspectos biológicos de la vejez. Máster en Gerontología Social. Facultad de Psicología. Universidad Autónoma. Madrid. (20.11.1992).

Enfermedad de Alzheimer: Perspectivas de futuro. Colegio de Médicos de Tenerife. Sta. Cruz de Tenerife. (9.12.1992).

1991

Perspectivas neuroquímicas en la enfermedad de Alzheimer. Centro de Biología Molecular, Universidad Autónoma de Madrid. Facultad de Ciencias, Madrid. (13.3.1991).

Curso de Doctorado: Psiconeuroendocrinología. Facultad de Medicina, Universidad Complutense, Madrid. (1.3-30.6-1991).

Therapeutic perspectives in Alzheimer’s disease. Institut de Recherches Internationales Servier (I.R.I.S.), París, Francia. (17.3.1991).

Lazaroides. Convención Upjohn. Hotel Meliá-Castilla, Madrid. (10.1.1991).

Perspectivas terapéuticas de la enfermedad de Alzheimer. IV Curso de Geriatría. Colegio Oficial de Médicos de León. Sociedad Castellano-Leonesa de Geriatría. León. (9.2.1991).

Sistema histaminérgico cerebral: Neurobiología y alteraciones en la enfermedad de Alzheimer. Seminarios de Neurociencia. Departamento de Morfología. Facultad de Medicina, Universidad Autónoma de Madrid. Madrid. (3.5.1991).

Influencia del sistema somatotropinérgico sobre funciones cognitivas. Curso doctorado (1991). Bioquímica de Péptidos Gastrointestinales. Directores: J.C. Prieto y E. Arilla. Departamento de Bioquímica y Biología Molecular. Facultad de Medicina, Universidad de Alcalá de Henares. Alcalá de Henares. (13.5.1991).

Fisiología del sueño en el anciano. Modificaciones bioquímicas y en el EEG. El anciano y el sueño. Convención Knoll, Hotel Palace, Madrid. (23.5.1991).

Fisiopatología de la memoria y envejecimiento. Mesa Redonda: Memoria y envejecimiento. Hotel Meliá-Madrid, Madrid. (24.5.1991).

Función neuroinmune en trastornos mentales. Curso doctorado. Instituto Cajal, CSIC, Madrid. (27.5.1991).

Psicofarmacología molecular en psiquiatría infantil. Jornadas sobre neurobiología y psicofarmacología en psiquiatría infanto-juvenil. Academia de ciencias médicas de Cataluña y Baleares, Barcelona. (31.5.1991).

Planificación legislativa en psicogeriatría. Jornada científica. Psiquiatría y Derecho, Orense. (8.6. 1991).

Calidad de vida en la tercera edad: Impacto social de la enfermedad de Alzheimer y otras demencias. Curso de salud mental y calidad de vida. Cátedra Jovellanos, Gijón. (11.7.1991).

Neuroimmune factors and neuropeptidergic treatment in Alzheimer’s disease. Department of Neuropsychiatry, Osaka University Medical School, Osaka, Japan. (24.9.1991).

Neuroimmune function in Alzheimer’s disease: Involvement of brain histamine in the pathogenesis of senile dementia. Department of Pharmacology II, Osaka University Medical School, Osaka, Japan. (26.9.1991).

Nuevas perspectivas en la enfermedad de Alzheimer. Facultad de Medicina. Universidad de Salamanca. (21.11.1991).

Enfermedad de Alzheimer: Tratamiento etiopatogénico. Sanatorio Sta. Teresa. Arévalo, Avila. (22.11.1991).

New trends in the etiopathogenetic treatment of Alzheimer’s disease. Tampere University, Tampere, Finland. (19.12.1991).