WGPGX

The first Guide, essential for the practical application of pharmacogenomics

In medicine there exists a desperate need to optimize the use of pharmaceutical resources, to reduce side-effects and unnecessary costs.

The capability of the population to metabolize correctly the active ingredients of each pharmaceutical product depends on the genetic profile of each person. Pharmacogenetics is responsible for over 80% of the efficacy and safety of drugs; however, lack of awareness of the pharmacogenetic profile of the population and the absence of pharmacogenetic information in the prospectuses of drugs result in over 50% of medical prescriptions being incorrect.
The aim of this project is to provide the scientific community with a tool to enable:

  • (i) in-depth awareness of the pharmacogenetics of the over 1,400 commonly-used drugs worldwide, approved by the FDA in the US, the EMA in Europe and by Koseisho in Japan.
  • (ii) a personalized use of drugs by physicians.
  • (iii) the definition of the relationship between the genetics of diseases and the level of pharmacogenetic intervention.

The World Guide for Drug Use and Pharmacogenomics (R. Cacabelos, Ed. EuroEspes Publishing, 2012) is the result of over five years’ work by a multidisciplinary team whose members, in addition to contributing their own professional experience, undertook the mission of searching the principal databases worldwide and reviewing thousands of papers on genetics, genomics, pharmacology, metabolism, therapeutics and pharmacogenetics, with the objective of systematizing the available knowledge of pharmacogenomics in an interactive database and in a volume which would be of use to physicians, geneticists, pharmacologists, pharmacists, molecular biologists, researchers, health professionals, regulatory agencies, health administrators and all other types of user with a desire to learn and to understand the keystones of practical, efficacious pharmacogenomic procedures.