Pharmacogenetic Guide

First essential guide to the practical application of pharmacogenomics
practical pharmacogenomics.

World guide for drug use an pharmacogenomics

World Guide for Drug use and Pharmacogenomics

- Ramón Cacabelos

In medicine, there is a pressing need to optimise the use of pharmaceutical resources to reduce side effects and unnecessary costs.

The ability of the population to adequately metabolise the active ingredients of each pharmaceutical product depends on the genetic profile of each person. Pharmacogenetics is responsible for more than 80% of the efficacy and safety of drugs; however, the lack of knowledge of the pharmacogenetic profile of the population and the lack of pharmacogenetic information in the package leaflets of medicines means that more than 50% of medical prescriptions are inappropriate.


The aim of this project is to provide the scientific community with a tool that will allow for:

  • An in-depth knowledge of the pharmacogenetics of more than 1400 drugs in common use around the world, approved by the FDA in the USA, the EMA in Europe and Koseisho in Japan.
  • Doctors to use medicines on a personalised basis more easily
  • The relationship between the genetics of diseases and the level of pharmacogenetic intervention to be defined

The World Guide for Drug Use and Pharmacogenomics (R. Cacabelos, Ed. EuroEspes Publishing, 2012) is the result of more than 5 years of multidisciplinary work involving many people who, in addition to sharing their professional experience, had the mission of searching the world's main databases and reviewing thousands of papers on genetics, genomics, pharmacology, metabolism, therapeutics and pharmacogenetics. Their aim was to systematise the available knowledge on pharmacogenomics in an interactive database and in a useful work for physicians, geneticists, pharmacologists, pharmacists, molecular biologists, researchers, health professionals, regulatory agencies, health administrators and all types of users willing to learn and understand the keys to practical and effective pharmacogenomics.


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