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Diseases of the Nervous System

Diseases of the nervous system are the third most common health problem in the world, behind cardiovascular diseases and cancer. However, the enormous variety of problems that can affect our brain is such that practically more than 98% of the population has suffered some brain problem during their lifetime.

 

Another fundamental aspect of nervous system diseases is their highly disabling component, in terms of quality of life, lost work hours, damage to self-esteem, psychological stigmatization, social isolation and compromise of our dignity as persons.

 

A vast majority of brain diseases require chronic treatment with medications that are not without side effects that can affect people's lives, increasing vulnerability to other pathologies.

Only 20-30% of available treatments are effective. In 60% of cases, pharmacological treatment is ineffective; in 20%, it is ineffective; in 30-40%, it causes toxicity.

Most of the adverse effects of medication can be avoided with a personalized pharmacological treatment, based on the pharmacogenetic profile of each patient.

Nervous system diseases are nowadays the main health problem in advanced societies. The best way to tackle them is with a Personalized Medicine that:

  • anticipates risk with Predictive Programs
  • increases early diagnostic accuracy with Genomic Diagnostics
  • personalizes pharmacological treatment with individual pharmacogenetic strategies
  • optimizes available resources, reduces unnecessary costs and substantially improves people's quality of life
  • Disorders of brain development
    • Intellectual disability
    • Global developmental delay
  • Structural developmental disorders
    • Congenital hydrocephalus
    • Neural tube defects
    • Segmentation, cleavage and midline defects
      • Holoprosencephaly
      • Septo-optic dysplasia
      • Agenesis of the corpus callosum
      • Arrhinencephaly
    • Neuronal migration defects
      • Lissencephaly
      • Periventricular nodular heterotopia
      •  Polymicrogyria
      •  Ulegiria
      •  Megalencephaly
      • Hemimegalencephaly
    • Posterior fossa anomalies
      • Arnold-Chiari malformation
      • Dandy-Walker malformation
      • Joubert's syndrome
      • Moebius syndrome
    • Abnormalities of the skull and spine
      • Craniosynostosis
      • Dwarfism
      • Deformities of the base of the skull and neck
        • Platabasia
        • Osteogenesis imperfecta
        • Hajdu-Cheney syndrome
        • Klippel-Feil anomaly
        • Occipitalization of the Atlas
  • Communication disorders
    • Language disorders
    • Phonological disorders
    • Childhood-onset fluency disorder (stuttering)
    • Social communication disorder (pragmatic)
  • Autism spectrum disorder
  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Specific learning disorders
    • Reading difficulties
    • Difficulties in written expression
    • Mathematical difficulty
  • Motor disorders
    • Developmental coordination disorder
    • Stereotyped movement disorder
    • Tourette's Disorder
    • Persistent motor or vocal tics (chronic)
    • Transient Tics
  • Spectrum of schizophrenia and other psychotic disorders
    • Schizotypal (Personality) Disorder
    • Delusional disorder
    • Brief psychotic disorder
    • Schizophreniform disorder
    • Schizophrenia
    • Schizoaffective disorder
    • Substance/medication-induced psychotic disorder
    • Psychotic disorder due to other pathology
    • Catatonia
  • Bipolar disorder and related disorders
    • Bipolar I disorder
    • Bipolar II disorder
    • Cyclothymic disorder
    • Bipolar disorder and related substance/medication-induced disorder
  • Depressive disorders
    • Disruptive mood dysregulation disorder
    • Major depressive disorder
    • Persistent depressive disorder (dysthymia)
    • Premenstrual dysphoric disorder
    • Substance/medication-induced depressive disorder
  • Anxiety disorders
    • Separation anxiety disorder
    • Selective mutism
    • Specific phobia
    • Social anxiety disorder (social phobia)
    • Panic disorder
    • Agoraphobia
    • Generalized anxiety disorder
    • Substance/medication-induced anxiety disorder
  • Obsessive-compulsive and related disorders
    • Obsessive-compulsive disorder
    • Body dysmorphic disorder
    • Accumulation disorder
    • Trichotillomania (hair pulling disorder)
    • Excoriation disorder (scratching of the skin)
    • Substance/medication-induced obsessive-compulsive disorder
  • Trauma-related disorders and stress factors
    • Reactive attachment disorder
    • Disinhibited Social Relationship Disorder
    • Post-traumatic stress disorder
    • Acute stress disorder
    • Adaptation disorders
  • Dissociative disorders
    • Dissociative identity disorder
    • Dissociative amnesia
    • Depersonalization/derealization disorder
  • Somatic symptom disorders and related disorders
    • Somatic symptom disorder
    • Sickness anxiety disorder
    • Conversion disorder (functional neurological symptom disorder)
    • Factitious disorder
  • Eating disorders and food intake disorders
    • Pica
    • Rumination disorder
    • Food intake avoidance/restriction disorder
    • Anorexia nervosa
    • Bulimia nervosa
    • Binge eating disorder
  • Excretion disorders
    • Enuresis
    • Encopresis
  • Sleep-wake disorders
    • Insomnia
    • Hypersomnia
    • Narcolepsy
    • Breathing-related sleep disorders
      • Obstructive sleep apnea
      • Central sleep apnea
      • Sleep-related hypoventilation
    • Disorders of circadian sleep-wake rhythms
    • Parasomnias
  • Sexual dysfunctions
    • Delayed ejaculation
    • Premature ejaculation
    • Erectile disorder
    • Female orgasmic disorder
    • Genitopelvic pain disorder/penetration disorder
    • Hypoactive sexual desire disorder in the male
    • Substance/medication-induced sexual dysfunction
  • Gender dysphoria

Disruptive, impulse control and behavioral disorders

      • Oppositional defiant disorder
      • Intermittent explosive disorder
      • Behavioral disorder
      • Antisocial personality disorder
      • Pyromania
      • Kleptomania
  • Substance-related and addictive disorders
    • Substance-related disorders
      • Alcohol use disorder
      • Alcohol intoxication
      • Abstinence from alcohol
    • Caffeine-related disorders
        • Caffeine intoxication
        • Caffeine withdrawal
    • Cannabis-related disorders
      • Cannabis use disorder
      • Cannabis intoxication
      • Cannabis withdrawal
    • Hallucinogen-related disorders
      • Phencyclidine use disorder
      • Phencyclidine poisoning
      • Hallucinogenic persistent perceptual disorder
      • Other hallucinogenic use disorder
    • Inhalant-related disorders
        • Inhalant use disorder
        • Inhalation poisoning
    • Opioid-related disorders
      • Opioid Use Disorder
      • Opiate intoxication
      • Opioid withdrawal
    • Sedative, hypnotic or anxiolytic drug use disorder.
    • Intoxication by sedatives, hypnotics or anxiolytics.
    • Abstinence from sedatives, hypnotics or anxiolytics.
    • Stimulant-related disorders
      • Stimulant use disorder
        • Amphetamine
        • Cocaine
        • Other stimulants
      • Stimulant intoxication
      • Stimulant withdrawal
      • Tobacco-related disorders
        • Tobacco use disorder
        • Tobacco abstinence
  • Neurocognitive disorders
    • Delirium
    • Alzheimer's disease
    • Frontotemporal neurocognitive disorder
    • Neurocognitive Lewy Body Disorder
    • Vascular neurocognitive disorder
    • Traumatic brain injury
    • Neuro-AIDS
    • Prion disease
    • Parkinson's disease
    • Huntington's disease
  • Personality disorders
    • Personality disorders: Cluster A
      • Paranoid personality disorder
      • Schizoid personality disorder
      • Schizotypal personality disorder
    • Personality disorders: Cluster B
      • Antisocial personality disorder
      • Borderline personality disorder
      • Histrionic personality disorder
      • Narcissistic personality disorder
    • Personality disorders: Cluster C
      • Avoidant personality disorder
      • Dependent personality disorder
      • Obsessive-compulsive personality disorder
  • Paraphilic disorders
      •  Voyeurism
      •  Exhibitionism
      •  Frotteurismo
      • Sexual masochism
      • Sexual sadism
      •  Fetishist
      • Transvestism
    • Degenerative and structural disorders
      • Degenerative structural disorders
        • Degenerative disc disease
          • Lumbosacral radiculopathies
          • Cervical radiculopathies
        • Cervical spondylosis
        • Ankylosing spondyloarthritis
      • Compressive structural disorders
        • Fibrous dysplasia
        • Paget's disease
        • Compressive neuropathies
  • Storage diseases
    • Neuronal ceroid-lipofuscinosis
    • Lipidosis
      • Gangliosidosis
      • Sphingomyelinosis
  • Cerebrosidosis
  • Mucopolysaccharidosis
  • Mucolipidosis
  • Glycogenosis
  •  Leukodystrophies
    • Pelizaeus-Merzbacher Syndrome
    • Cockayne syndrome
  • Alexander syndrome
  • Canavan syndrome
  • Krabbe syndrome
  • Metachromatic leukodystrophies
  • Peroxisomal leukodystrophies
    • Adrenoleukodystrophies
  • Other lipidoses
    • Fabry disease
    • Non-infantile Refsum disease
  • Abetalipoproteinemia
    • Bassem-Kornzweig syndrome
  • α-lipoproteinemia
    • Tangier disease
  • Aminoacidopathies and organic acidopathies
  • Hereditary disorders related to the metabolism of vitamins.
    • Biotin-sensitive encephalopathy
    • Vitamin B12 metabolism disorders
    • Methylenetetrahydrofolate reductase deficiency
  • Mitochondrial enzyme defects
    • Subacute necrotizing encephalomyelopathy
      • Leigh's disease
    • Progressive infantile polyodystrophy
      • Alper's disease
    • Lethal infant mitochondrial disease
    • Congenital lactic acidosis
    • Myoclonic epilepsy and irregular red fiber syndrome.
    • Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes.
    • Chronic progressive external progressive ophthalmoplegia
    • Kearns-Sayre syndrome
    • Leber hereditary optic neuropathy
    • Malignant migraine
    • Neuropathy syndrome, ataxia, retinitis pigmentosa
    • Mitochondrial myopathies
    • Reye's syndrome
  • Fatty acid oxidation disorders
    • Medium-chain acyl-CoA dehydrogenase deficiency
    • Carnitine transport defect
    • Carnitine palmitoyl transferase II deficiency
  • Other metabolic disorders
    • Transport defects
  • Lesch-Nyhan disease (hypoxanthine-guanine phosphoribosyltransferase deficiency)
  • Glycoprotein Carbohydrate Deficiency Glycoprotein Syndrome
    • Carbohydrate-deficient glycoprotein syndrome
    • Porphyrias
  • Chromosomal abnormalities
    • Autosomal aberrations
      • Trisomy 21 (Down syndrome)
      • Trisomy 18 (Edward syndrome)
      • Trisomy 13 (Patau's syndrome)
      • Prader-Willi syndrome
    • Aberrations of the sex chromosomes
      • Klinefelter's syndrome
      • XYY Syndrome
      • Turner syndrome
      • Fragile X Syndrome
    • Facomatosis
      • Autosomal dominant diseases
        • Neurofibromatosis (Von Recklinghausen's disease)
        • Incontinentia Pigmenti Achromians (hypomelanosis of Ito)
        • Rendu-Osler-Weber Syndrome
        • Waardenburg syndrome
        • Von Hippel-Lindau disease
      • Autosomal recessive diseases
        • Ataxia-Telangiectasia
        • Chédiak-Higashi syndrome
        • Refsum Syndrome
        • Rothman-Thomson syndrome
        • Rud Syndrome
        • Sjögren-Larsson Syndrome
        • Xeroderma pigmentosum
  • X-linked inheritance
    • Fabry-Anderson disease
    • Incontinentia pigmenti (Bloch-Sulzberger syndrome)
  • Neurodegenerative dementias (neurocognitive disorders)
    • Cortical dementias
      • Alzheimer's disease
      • Asymmetric cortical degeneration syndromes
  • Pick's disease
  • Frontotemporal degeneration
  • Subcortical dementias
    • Parkinson-Dementia Complex
    • Multisystem atrophy
  • Progressive supranuclear palsy
  • Huntington's disease
  • Mixed cortical-subcortical dementias
    • Corticobasal degeneration
    • Lewy body dementia
  • Movement disorders
    • Hypokinetic movement disorders
      • Parkinson's disease
      • Parkinson-Plus Syndromes
    • Hyperkinetic movement disorders
      • Huntington's disease
      • Korea essential
  • Primary dystonia
  • Hallervorden-Spatz disease
  • Gilles de la Tourette's syndrome
  • Tics
  • Stereotypies
  • Restless legs syndrome
  • Pain syndrome of legs and toes
  • Action tremors (tremors without rest)
  • Essential tremor
  • Wilson's disease
  • Hemifacial spasm
  • Essential myoclonus
  • Startle syndromes
  • Ataxias
    • Congenital ataxias
    • Hereditary ataxias
      • Autosomal dominant disorders
      • Autosomal recessive disorders
    • Idiopathic non-hereditary cerebellar ataxia
    • Symptomatic ataxias
  • Degenerative motor, sensory, and autonomic disorders.
    • Degenerative upper and lower motor neuron disorders
      • Amyotrophic Lateral Sclerosis
      • Spinal muscular atrophies
  • Hereditary spastic paraplegia
  • Degenerative muscle disorders
    • Dystrophinopathies
      • Duchenne muscular dystrophy
      • Becker muscular dystrophy
    • Limb-girdle muscular dystrophies
  • Facioscapulohumeral muscular dystrophy
  • Scapuloperoneal syndromes
  • Myotonic dystrophy
  • Oculopharyngeal muscular dystrophy
  • Emery-Dreifuss muscular dystrophy
  • Distal myopathies
  • Degenerative neuropathies
    • Hereditary sensory and motor neuropathies
    • Hereditary sensory and autonomic neuropathies
  • Multi-system atrophy autonomic neuropathy
    • Shy-Drager syndrome
  • Hereditary nondegenerative neuromuscular disease
    • Muscular channelopathies (myotonias and periodic paralysis)
      • Sodium channelopathies
      • Chloride channelopathies
  • Calcium channelopathies
  • Potassium channelopathies
  • Possible muscular canalopathy
    • Schwartz-Jampel syndrome
  • Congenital myopathies
    • Nemaline myopathy
    • Myotubular/centronuclear myopathy
      • Central core disease
      • Congenital disproportion of fiber type
    • Congenital myasthenia
    • Malignant hyperthermia
    • Familial amyloid polyneuropathy
    • Axonal neuropathy
    • Isaac's disease
  • Endogenous metabolic disorders
    • Electrolyte abnormalities
      • Sodium disorders
      • Potassium disorders
  • Calcium disorders
  • Magnesium disorders
  • Oxygen and carbon dioxide abnormalities
    • Hypoventilation
    • Hypoxia
  • Hypocapnia
  • Endocrine abnormalities
    • Thyroid disorders
    • Parathyroid disorders
  • Adrenal disorders
  • Growth hormone disorders
  • Glucose Metabolism Disorders
  • Diabetes
  • Organic failure
    • Hepatic insufficiency
    • Renal insufficiency
  • Exogenous acquired metabolic disorders of the nervous system
    • Metal poisoning
      • Arsenic
      • Inorganic lead
  • Organic lead
  • Manganese
  • Inorganic mercury
  • Organic mercury
  • Aluminum
  • Thallium
  • Other metals
  • Organic solvents
    • Mixed Solvents
    • Methyl alcohol
  • Ethylene glycol
  • N-hexane and methyl-N-butyl ketone
  • Toluene (methylbenzene)
  • Trichloroethylene
  • Acetone
  • Benzene
  • Carbon Disulfide
  • Carbon tetrachloride
  • Gases
    • Carbon monoxide
    • Cyanide
  • Ethylene oxide
  • Nitrous oxide
  • Pesticides
    • Organophosphorus insecticides
    • Organochlorine insecticides
  • Methyl bromide
  • Picrotoxin
  • Strychnine
  • Animal toxins
    • Snake, scorpion and spider venoms
    • Tick paralysis
  • Plant toxins
    • Chickpea (Latirism)
    • Mushrooms
  • Bacterial toxins
    • Diphtheria
    • Tetanus
  • Botulism
  • Illicit drugs
    • Cocaine
    • Amphetamine analogs
  • Methylenedioxymethamphetamine
  • Opioid agonists
  • Hallucinogens
  • Methyl-phenyl-tetrahydropyridine
  • Phencyclidine
  • Cannabinol (marijuana)
  • Nutritional deficiencies
    • Vitamin deficiencies
      • Thiamine
      • Niacin and nicotinic acid
  • Cobalamin (vitamin B12)
  • Pyridoxine (Vitamin B6)
  • Vitamin A, D, E
  • Pantothenic acid
  • Protein-energy malnutrition
  • Alcohol-related problems
    • Acute intoxication
    • Withdrawal syndromes
  • Alcoholic dementia
  • Amblyopia due to deficiency
  • Cerebellar degeneration
  • Marchaifava-Bignami disease
  • Alcoholic myopathy
  • Alcohol-related movement disorders
  • Fetal alcohol syndrome
  • Viral Infections
    • RNA viruses
      • Enterovirus
      • Ecovirus
  • Coxsackievirus
  • Poliovirus
  • Mumps
  • Arthropod-borne viruses
  • Influenza virus
  • Measles
  • Arenavirus
    • Lymphocytic choriomeningitis virus
  • Rubella
  • Human T-cell lymphotropic virus type 1
  • Coronavirus
  • DNA viruses
    • Herpes simplex
    • Varicella zoster virus
  • Cytomegalovirus
  • Human herpesvirus-6
  • Epstein Barr Virus
  • Smallpox virus
    • Smallpox
  • JC Virus
  • Non-Viral Infections
    • Bacterial infections
      • Acute bacterial meningitis
      • Brain abscess
  • Cranial and spinal subdural empyema
  • Cranial and spinal epidural abscess
  • Cat scratch disease
  • Whipple's disease
  • Mycobacterial infections
    • Mycobacterium tuberculosis
    • Mycobacterium avium
  • Spirochete infections
    • Neurosyphilis
    • Lyme disease
  • Other tick-borne infections
    • Ehrlichiosis
    • Rocky Mountain Spotted Fever
  • Babesiosis
  • Fungal infections
    • Cryptococcus neoformans
    • Histoplasma capsulatum
  • Coccidioides immitis
  • Blastomyces dermatitidis
  • Aspergillus fumigatus
  • Candida
  • Cygomycetes
  • Amoebic infections
  • Neurocysticercosis
  • Malaria
  • Transmissible spongiform encephalopathy
    • Prion disease
    • Sporadic disease
    • Family illness
    • Iatrogenic disease
    • Creutzfeldt-Jakob Disease
  • Human immunodeficiency virus and acquired immunodeficiency syndrome
    • HIV-related central nervous system disorders
      • Septic meningitis
      • HIV-associated cognitive impairment
  • HIV-associated myelopathies
  • HIV-related disorders of the peripheral nervous system
    • HIV-associated neuropathies
    • HIV-1-related myopathies
  • HIV-associated neoplasms
    • Primary central nervous system lymphoma
    • Metastatic non-Hodgkin's lymphoma
  • AIDS-related opportunistic infections
  • Neurovascular disorders
    • Ictus
    • Atherothrombotic disease
    • Occlusive disease of small penetrating arteries
    • Cerebral embolism
    • Systemic hypotension
      • Border zone infarction
    • Non-atherosclerotic occlusive diseases
    • Hemorrhagic cerebrovascular diseases
      • Primary intracerebral hemorrhage
      • Subarachnoid hemorrhage
  • Arteriovenous malformations
  • Traumatic neurovascular diseases
    • Carotid-cavernous sinus fistulas
    • Subdural hematomas
  • Epidural hematomas
  • Strokes of the spinal cord
  • Primary neurological tumors
    • Neuroectodermal tumors
      • Glioma, astrocytoma and low-grade pilocytic astrocytoma
      • Anaplastic astrocytoma
  • Glioblastoma multiforme
  • Oligodendroglioma
  • Oligoastrocytoma
  • Ependymoma
  • Medulloblastoma
  • Primary CNS lymphoma
  • Nerve Sheath Tumors
    • Acoustic schwannoma
    • Trigeminal Neurilemoma
  • Neurofibroma
  • Peripheral nerve tumors
  • Spinal cord tumors
  • Pituitary tumors
    • Dermoid, epidermoid and teratoma
    • Tumors of the pineal gland and germ cells
  • Hemangioblastoma
  • Chordoma
  • Tumors of the jugular glomus (carotid body)
  • Colloid cysts
  • Papilloma of the choroid plexus
  • Metastatic neoplasms
    • Intraparenchymal metastases
    • Meningeal and ventricular metastases
    • Skull base metastases
    • Spinal metastases
    • Peripheral nerve metastases
  • Paraneoplastic syndromes
  • Demyelinating disorders
    • Multiple sclerosis
    • Neuromyelitis optica
    • Acute disseminated encephalomyelitis
    • Acute inflammatory inflammatory demyelinating polyradiculoneuropathy
      • Guillain-Barré Syndrome
    • Chronic inflammatory inflammatory demyelinating polyradiculoneuropathy
    • Monoclonal gammopathies
    • Multiple myeloma
    • Waldeström's Macroglobulinemia
    • Osteosclerotic myeloma
    • Multifocal motor neuropathy with conduction block
  • Autoimmune and inflammatory disorders
    • Inflammatory vasculopathies: arteritis
      • Extracranial granulomatous arteritis
        • Giant cell temporal arteritis
      • Intracranial granulomatous arteritis
        • Primary angiitis
  • Takayasu's arteritis
  • Polyarteritis nodosa
    • Churg-Strauss syndrome
  • Wegener's granulomatosis
  • Vasculitis associated with antiphospholipid antibodies
  • Thromboangiitis obliterans
    • Buerger's syndrome
  • Connective tissue diseases
    • Rheumatoid arthritis
    • Systemic lupus erythematosus
  • Progressive systemic sclerosis
  • Mixed connective tissue disease
  • Sjögren's syndrome
  • Myasthenia gravis
  • Dermatomyositis
  • Polymyositis
  • Eosinophilic myositis
  • Inclusion body myositis
  • Behçet's disease
  • Traumatic disorders
    • Acute head injury
    • Post-concussion syndrome
    • Cranial neuropathies
    • Post-traumatic epilepsy
    • Post-traumatic movement disorders
    • Spinal cord injury
    • Whiplash injuries
    • Brachial and lumbosacral plexopathies
    • Reflex sympathetic dystrophy and causalgia
    • Mountain sickness
    • Decompression sickness
    • Electrical and lightning injuries
  • Epilepsy
    • Types of self-limited seizures
      • Generalized seizure
        • Attack of great evil
        • Clonic seizure
        • Typical absence seizures
        • Atypical absence seizures
        • Myoclonic absence seizures
        • Tonic seizure
        • Spasms
        • Myoclonic seizures
        • Eyelid myoclonus
        • Myoclonic atonic seizures
        • Negative myoclonus
        • Atonic crises
      • Focal crisis
        • Sensory Focal Crisis
        • Focal motor seizures
        • Gelastic seizures
  • Hemiclonic seizures
  • Secondary generalized seizures
  • Types of continuous seizures
    • Generalized status epilepticus
    • Generalized tonic-clonic status epilepticus
      • Clonic status epilepticus
      • Status or absence epilepticus
      • Tonic status epilepticus
      • Myoclonic status epilepticus
  • Focal status epilepticus
    • Continuous partial status of Kojevnikov
    • Aura continues
    • Limbic status epilepticus (psychomotor status)
    • Status or hemiconvulsive
  • Headache
    • Migraine
    • Tension headache
    • Cluster headache
    • Chronic paroxysmal hemicrania
    • Idiopathic intracranial hypertension
    • Hypotensive headache
  • Cervico-facial pain
    • Trigeminal neuralgia
    • Cervicogenic headache
    • Occipital neuralgia
    • Glossopharyngeal neuralgia
    • Carotidinia
  •  

Our Prevention Plans allow us to identify prevalent diseases in pre-symptomatic or early stages and to intervene prophylactically so that they do not manifest themselves, delay their onset or can be intervened therapeutically in an effective way with personalized protocols of individual pharmacogenetics.

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