Migraines - MIGRASCREEN
Detects the origin of your migraine. Analyzes the level of Histamine in blood and DAO activity.
MIGRASCREEN provides a graphic report with the results of blood histamine and diamine oxidase (DAO) activity tests. It includes a list of foods with high histamine content to eliminate or reduce in those cases of high histamine blood levels or DAO enzyme deficiency that generate pathologies such as toxic histaminosis, histamine intolerance or non-allergic histaminosis.
DAO deficiency leads to the inability to degrade histamine and, consequently, to the accumulation of histamine and the occurrence of adverse health effects including migraines and headaches.
Diamine oxidase, also known as histaminase, is an enzyme (EC 1.4.3.22) involved in the metabolism, oxidation and inactivation of histamine in animals. The highest content is observed in the digestive tract and placenta. It is also secreted by eosinophils.
In childhood and adolescence, DAO deficiency has been linked to attention deficit hyperactivity disorder (ADHD).
Histamine (HA) belongs to the group of biogenic amines, which are low molecular weight nitrogenous compounds formed by the decarboxylation of amino acids. Histamine is released when the allergic reaction is triggered and causes inflammation. It is the cause of many allergy symptoms, such as the hives, redness and itching seen in urticaria or the nasal congestion, nasal itching and sneezing seen in allergic rhinitis.
Histamine can also be found in many foods in high quantities and its excess in the body, in people with or without problems in its metabolism (enzymatic deficit in many cases) is associated with migraines. This produces what is called histamine intolerance or toxic histaminosis (image B and C).
In other situations, due to an immunological reaction to food, a histamine release is triggered, resulting in various adverse symptoms such as diarrhea, urticaria and others. In this case it would be a non-allergic food histaminosis (HANA) (image D).
Histamine has also been associated with CNS diseases.
Histamine determination is performed by high performance liquid chromatography (HPLC), a reference technique, with post-column derivatization (OPA) and fluorimetric detection, ensuring ultra-sensitivity and high specificity to the analytical system. Our ultra-sensitive HPLC system achieves a histamine detection rate of 5 pg or 1×107 ppm.
The radioimmunoassay technique is used to determine the activity (not concentration!) of the DAO enzyme.
MIGRASCREEN Application
You can request the MIGRASCREEN test by calling us at 981 780 505. If you prefer, leave us your details using the following form and we will contact you: